Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.T...Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.This may be attributed to the limited range of neurotransmitters that are regulated by psychotropic drugs.Recent findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitte rs.Among these candidate neurotransmitters,lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent years.Previous studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses;animal experiments have also shown that the supply of exogenous la ctate exerts an antidepressant effect.In this review,we have described how medications targeting newer neurotransmitte rs offer promise in psychiatric diseases;we have also summarized the advances in the use of lactate(and its corresponding signaling pathways)as a signaling molecule.In addition,we have described the alterations in brain lactate levels in depression,anxiety,bipolar disorder,and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology.展开更多
Gravity Anomaly Correction(GAC)is a very important term in leveling data processing.In most cases,it is troublesome for field surveyors to measure gravity when leveling.In this paper,based on the complete Bouguer Grav...Gravity Anomaly Correction(GAC)is a very important term in leveling data processing.In most cases,it is troublesome for field surveyors to measure gravity when leveling.In this paper,based on the complete Bouguer Gravity Anomaly(BGA)map of WGM2012,the feasibility of replacing in-situ gravity surveying in China is investigated.For leveling application,that is to evaluate the accuracy of WGM2012 in China.Because WGM2012 is organized with a standard rectangle grid,two interpolation methods,bilinear interpolating and Inverse Distance Weighted(IDW)interpolating,are proposed.Four sample areas in China,i.e.,Hanzhong,Chengdu,Linzhi and Shantou,are selected to evaluate the systems bias and precision of WGM2012.Numerical results show the average system bias of WGM2012 BGA in west China is about-100.1 mGal(1 mGal=10^(-5) m/s^(2))and the standard deviation is about 30.7 mGal.Tests in Shantou indicate the system bias in plain areas is about-130.4 mGal and standard deviation is about 6.8 mGal.All these experiments means the accuracy of WGM2012 is limited in high mountain areas of western China,but in plain areas,such as Shantou,WGM2012 BGA map is quite good for most leveling applications after calibrating the system bias.展开更多
Brain Glycogen Works as an Angel Under Physiological Condition Glycogen Metabolism in the Brain One of the unique characteristics of the brain is its diversity in neural cell types,and neurons and astrocytes exhibit d...Brain Glycogen Works as an Angel Under Physiological Condition Glycogen Metabolism in the Brain One of the unique characteristics of the brain is its diversity in neural cell types,and neurons and astrocytes exhibit different metabolic patterns[1].Glycogen mainly exists in astrocytes,not in neurons[2].Glycogen metabolism is conservative throughout the body.Similar to the liver and muscle,the astrocytic glycogen level is controlled by glycogenesis and glycogenolysis[3].展开更多
We demonstrate an ultralow-noise single-photon detection system based on a sensitive photomultiplier tube(PMT) with precise temperature control, which can capture fast single photons with intervals around 10 ns.By i...We demonstrate an ultralow-noise single-photon detection system based on a sensitive photomultiplier tube(PMT) with precise temperature control, which can capture fast single photons with intervals around 10 ns.By improvement of the electromagnetic shielding and introduction of the self-differencing method, the dark counts(DCs) are cut down to ~1%. We further develop an ultra-stable PMT cooling subsystem and observe that the DC goes down by a factor of 3.9 each time the temperature drops 10°C. At -20°C it is reduced 400 times with respect to the room temperature(25°C), that is, it becomes only 2 counts per second, which is on par with the superconducting nanowire detectors. Meanwhile, despite a 50% loss, the detection efficiency is still 13%. Our detector is available for ultra-precise single-photon detection in environments with strong electromagnetic disturbances.展开更多
基金financially supported by the National Nature Science Foundation of China,Nos.82271508(to YC)82001384(to YC)82271316(to HG)。
文摘Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.This may be attributed to the limited range of neurotransmitters that are regulated by psychotropic drugs.Recent findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitte rs.Among these candidate neurotransmitters,lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent years.Previous studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses;animal experiments have also shown that the supply of exogenous la ctate exerts an antidepressant effect.In this review,we have described how medications targeting newer neurotransmitte rs offer promise in psychiatric diseases;we have also summarized the advances in the use of lactate(and its corresponding signaling pathways)as a signaling molecule.In addition,we have described the alterations in brain lactate levels in depression,anxiety,bipolar disorder,and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology.
基金“Wings of Quality”Program of QICS(No.2020-zlzy-015)。
文摘Gravity Anomaly Correction(GAC)is a very important term in leveling data processing.In most cases,it is troublesome for field surveyors to measure gravity when leveling.In this paper,based on the complete Bouguer Gravity Anomaly(BGA)map of WGM2012,the feasibility of replacing in-situ gravity surveying in China is investigated.For leveling application,that is to evaluate the accuracy of WGM2012 in China.Because WGM2012 is organized with a standard rectangle grid,two interpolation methods,bilinear interpolating and Inverse Distance Weighted(IDW)interpolating,are proposed.Four sample areas in China,i.e.,Hanzhong,Chengdu,Linzhi and Shantou,are selected to evaluate the systems bias and precision of WGM2012.Numerical results show the average system bias of WGM2012 BGA in west China is about-100.1 mGal(1 mGal=10^(-5) m/s^(2))and the standard deviation is about 30.7 mGal.Tests in Shantou indicate the system bias in plain areas is about-130.4 mGal and standard deviation is about 6.8 mGal.All these experiments means the accuracy of WGM2012 is limited in high mountain areas of western China,but in plain areas,such as Shantou,WGM2012 BGA map is quite good for most leveling applications after calibrating the system bias.
基金supported by the National Natural Science Foundation of China(82001384 and 81901079)the Hygiene and Health Technology Program of Shaanxi Province of China(2022D001).
文摘Brain Glycogen Works as an Angel Under Physiological Condition Glycogen Metabolism in the Brain One of the unique characteristics of the brain is its diversity in neural cell types,and neurons and astrocytes exhibit different metabolic patterns[1].Glycogen mainly exists in astrocytes,not in neurons[2].Glycogen metabolism is conservative throughout the body.Similar to the liver and muscle,the astrocytic glycogen level is controlled by glycogenesis and glycogenolysis[3].
基金supported by the National Natural Science Foundation of China(Nos.11574026 and 11274037)the Program for New Century Excellent Talents in University,MOE of China(No.NCET-12-0765)the Foundation for the Author of National Excellent Doctoral Dissertation,China(No.201236)
文摘We demonstrate an ultralow-noise single-photon detection system based on a sensitive photomultiplier tube(PMT) with precise temperature control, which can capture fast single photons with intervals around 10 ns.By improvement of the electromagnetic shielding and introduction of the self-differencing method, the dark counts(DCs) are cut down to ~1%. We further develop an ultra-stable PMT cooling subsystem and observe that the DC goes down by a factor of 3.9 each time the temperature drops 10°C. At -20°C it is reduced 400 times with respect to the room temperature(25°C), that is, it becomes only 2 counts per second, which is on par with the superconducting nanowire detectors. Meanwhile, despite a 50% loss, the detection efficiency is still 13%. Our detector is available for ultra-precise single-photon detection in environments with strong electromagnetic disturbances.