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适配体技术及其在植物科学研究中的应用
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作者 李奕 张曦 +2 位作者 袁艳辉 公丕昌 林金星 《植物学报》 CAS CSCD 北大核心 2023年第6期935-945,共11页
适配体是一种从人工合成的文库中筛选出来、能够特异结合靶标分子的单链寡核苷酸或多肽。适配体基于自身结构和序列与靶分子特异结合并调节其活性,应用于生物体内分子功能研究及新型药物制剂的研发。近年来,多肽适配体广泛应用于医学、... 适配体是一种从人工合成的文库中筛选出来、能够特异结合靶标分子的单链寡核苷酸或多肽。适配体基于自身结构和序列与靶分子特异结合并调节其活性,应用于生物体内分子功能研究及新型药物制剂的研发。近年来,多肽适配体广泛应用于医学、遗传学和分子生物学等多个领域,成为一种高效、特异且功能强大的新工具。在植物研究中,随着相应体系的建立、应用和推广,适配体技术逐渐成为研究植物分子功能的有效工具。该文综述了不同类型的适配体、筛选原理及优缺点,以及在植物研究中的应用。可以预见,随着分子设计育种技术的发展,适配体技术有望成为植物科学领域有价值的应用工具。 展开更多
关键词 适配体 核酸 多肽 植物 筛选
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A ZnO thin-film driven microcantilever for nanoscale actuation and sensing 被引量:3
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作者 yanhui yuan Kun Shyong Chow +4 位作者 Hejun Du Peihong Wang Mingsheng Zhang Shengkai Yu k Bo Liu 《International Journal of Smart and Nano Materials》 SCIE EI 2013年第2期128-141,共14页
Zinc oxide(ZnO)thin film as a piezoelectric material for microelectromechanical system(MEMS)actuators and sensors was evaluated.ZnO thin films were deposited using radio frequency(RF)magnetron sputtering.Process param... Zinc oxide(ZnO)thin film as a piezoelectric material for microelectromechanical system(MEMS)actuators and sensors was evaluated.ZnO thin films were deposited using radio frequency(RF)magnetron sputtering.Process parameters such as gas ratio,working pressure,and RF power were optimized for crystalline structure.The ZnO thin films were characterized by X-ray diffraction(XRD)and scanning electron microscopy(SEM).Good quality of ZnO thin films was further confirmed by a high transverse piezoelectric coefficient d31.A microcantilever was then designed,fabricated,and characterized.Design formulas of resonant frequency,actuation,and sensing sensitivities were derived.The resonant frequency was determined by an impedance analyzer.Tip deflection on nanometer level was demonstrated with the cantilever used as an actuator.The actuation sensitivity was found to be 12.2 nm/V.As a sensor,the cantilever was calibrated against a reference accelerometer.The sensing sensitivity was characterized to be 46 mV/g.The characterization results were compared with design specifications.The differences were caused mainly by thickness control in etching.This study showed that ZnO is a promising piezoelectric material for MEMS actuators and sensors in terms of excellent process compatibility and good piezoelectric performance. 展开更多
关键词 ZNO ACTUATION SENSING MICROCANTILEVER MEMS
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