“N-Two-N”教学模式的构建及在本科有机化学教学中的探究实践

基于立德树人的核心目标,探索了本科有机化学教学的新思路,从提高教师引导作用、提升学生自主学习能力、优化评价考核方式等方面进行了探索与研究。本研究以CDIO-BOPPPS协同教学模式为指导思想,引入CDIO理念创新教学设计构思,借鉴BOPPPS模式改革教学过程,结合多种教学法和多种评价方式,构建一个“N-Two-N”一体化的课堂教学体系。本文阐述了“N-Two-N”一体化模式的落实过程以及该教学模式的优点和取得的成效。

靛蓝的智勇大冲关

借助化学闯关游戏,以“对话”“游戏互动”的形式,介绍了靛蓝的植物来源、发展历史、结构、性质、制备以及应用,使读者能够在学习靛蓝的同时感受到化学的乐趣。

Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis

Herein,a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated.A wide range of functional groups are compatible,affording the corresponding products in moderate-to-good yields.Control experiments illustrate that the in situ generated^(1)O_(2)plays a central role in this reaction.This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.

Molecular oxygen-mediated selective hydroxyalkylation and alkylation of quinoxalin-2(1H)-ones with alkylboronic acids

Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.