The abuse of opioids is harmful to the national economy and health.The U.S.government has spent a lot of time,energy and money to deal with this phenomenon.Based on the topic background and team discussion,we deeply e...The abuse of opioids is harmful to the national economy and health.The U.S.government has spent a lot of time,energy and money to deal with this phenomenon.Based on the topic background and team discussion,we deeply excavated the data and information provided in the topic,determined the current use of opioids,and constructed an improved SIR model to determine the source of drug abuse,the mechanism of drug abuse diffusion and the origin of each state through reverse derivation,which provided guidance for the government in the context of opioid abuse.Based on the above results,we simulated and analyzed the improved SIR model and determined the accuracy and stability of the model in the data set.展开更多
Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements fo...Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements for adsorbents. Aptamers exhibit perfect selectivity and easy regeneration, which make them uniquely effective adsorption materials. Herein, we have rationally designed novel aptamer-based adsorbents and investigated their performance in extraction/ separation of targets from an aqueous solution. These adsorbents can selectively extract targets from complicated sample matrices containing background compounds. Moreover, they can also be easily recycled without a significant loss of adsorption capacity. Notably, the adsorbents did not affect the activity of isolated biological samples, revealing their potential for the purification/separation of biomolecules. Composite adsorbents were constructed using aptamer-based adsorbents and a porous polymer, displaying highly efficient target separation from aqueous solution. Finally, separation columns were constructed, and targets in the aqueous solution were efficiently separated by these columns. The aptamerbased adsorbents described here exhibit great promise for potential applications in separation technology, biotechnology, and environment-related areas.展开更多
文摘The abuse of opioids is harmful to the national economy and health.The U.S.government has spent a lot of time,energy and money to deal with this phenomenon.Based on the topic background and team discussion,we deeply excavated the data and information provided in the topic,determined the current use of opioids,and constructed an improved SIR model to determine the source of drug abuse,the mechanism of drug abuse diffusion and the origin of each state through reverse derivation,which provided guidance for the government in the context of opioid abuse.Based on the above results,we simulated and analyzed the improved SIR model and determined the accuracy and stability of the model in the data set.
基金Acknowledgements This work was supported by the National Natural Science Foundation of China （Nos. 51272186 and 21422105）, ＂A Foundation for the Author of National Excellent Doctoral Dissertation of P. R. China＂ （No. 201220）, and Ten Thousand Talents Program for Young Talents. Q. Y. thanks for large-scale instrument and equipment sharing foundation of Wuhan University.
文摘Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements for adsorbents. Aptamers exhibit perfect selectivity and easy regeneration, which make them uniquely effective adsorption materials. Herein, we have rationally designed novel aptamer-based adsorbents and investigated their performance in extraction/ separation of targets from an aqueous solution. These adsorbents can selectively extract targets from complicated sample matrices containing background compounds. Moreover, they can also be easily recycled without a significant loss of adsorption capacity. Notably, the adsorbents did not affect the activity of isolated biological samples, revealing their potential for the purification/separation of biomolecules. Composite adsorbents were constructed using aptamer-based adsorbents and a porous polymer, displaying highly efficient target separation from aqueous solution. Finally, separation columns were constructed, and targets in the aqueous solution were efficiently separated by these columns. The aptamerbased adsorbents described here exhibit great promise for potential applications in separation technology, biotechnology, and environment-related areas.
