Near infrared(NIR)absorbers for photothermal therapy are arousing great attention in tumor diagnosis and ablation.However,the inevitably wide distribution of NIR absorbers generally causes equal photothermal injuries ...Near infrared(NIR)absorbers for photothermal therapy are arousing great attention in tumor diagnosis and ablation.However,the inevitably wide distribution of NIR absorbers generally causes equal photothermal injuries to tumor tissues and healthy tissues.An initiative targeting strategy based on pH-sensitive redshift absorption has been proposed for NIR-induced hyperthermia only in tumor tissue.In this work,we develop a NIR absorber with superlarge redshift from the middle visible light region to NIR light region once the pH value drops.展开更多
Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors u...Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors underneath skin because of the light scattering effect of skin components.This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect from the refractive index inhomogeneity among skin constituents.展开更多
Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides wit...Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides with an acid-cleavable silaketal linkage on their backbones that enables control of hydrolysis.These pesticides possess outstanding bactericidal and insecticidal properties but become harmless to humans and other organisms after hydrolysis.Depending on the conditions of use,the hydrolytic process can be controlled over the time range of 10 min to 3 months.Both laboratory simulations and agricultural field demonstrations confirm that these pesticides can effectively protect crops from bacterial diseases and pests.At the sametime,single-dose intragastric administration using diisopropylsilyloxy bisquaternary ammonium salt 9(ISBQAS-9)in mice demonstrates its safety for multiple organs.Owing to the advantages of controllable degradability,environmental friendliness,and the low financial cost of these pesticides,this welldesigned strategy holds great promise for the generation of environmentally harmless pesticides and the development of green agriculture.展开更多
基金supported by the National Natural Science Foundation of China(nos.21825503 and 21674127).
文摘Near infrared(NIR)absorbers for photothermal therapy are arousing great attention in tumor diagnosis and ablation.However,the inevitably wide distribution of NIR absorbers generally causes equal photothermal injuries to tumor tissues and healthy tissues.An initiative targeting strategy based on pH-sensitive redshift absorption has been proposed for NIR-induced hyperthermia only in tumor tissue.In this work,we develop a NIR absorber with superlarge redshift from the middle visible light region to NIR light region once the pH value drops.
基金from the National Natural Science Foundation of China(grant no.21825503).
文摘Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors underneath skin because of the light scattering effect of skin components.This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect from the refractive index inhomogeneity among skin constituents.
基金the National Natural Science Foundation of China(grant nos.21825503 and 22335008).
文摘Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides with an acid-cleavable silaketal linkage on their backbones that enables control of hydrolysis.These pesticides possess outstanding bactericidal and insecticidal properties but become harmless to humans and other organisms after hydrolysis.Depending on the conditions of use,the hydrolytic process can be controlled over the time range of 10 min to 3 months.Both laboratory simulations and agricultural field demonstrations confirm that these pesticides can effectively protect crops from bacterial diseases and pests.At the sametime,single-dose intragastric administration using diisopropylsilyloxy bisquaternary ammonium salt 9(ISBQAS-9)in mice demonstrates its safety for multiple organs.Owing to the advantages of controllable degradability,environmental friendliness,and the low financial cost of these pesticides,this welldesigned strategy holds great promise for the generation of environmentally harmless pesticides and the development of green agriculture.
