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微小残留病检测在多发性骨髓瘤移植后患者中的应用现状与思考 被引量:2
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作者 许艳洁 张翼鷟 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第11期548-552,共5页
多发性骨髓瘤(multiple myeloma,MM)患者的治疗疗效在近十年来不断提高,特别是在新药联合移植治疗后,其无进展生存期(progression free survival,PFS)和总生存期(overall survival,OS)均大幅延长。对于患者的疗效而言,传统意义的评效标... 多发性骨髓瘤(multiple myeloma,MM)患者的治疗疗效在近十年来不断提高,特别是在新药联合移植治疗后,其无进展生存期(progression free survival,PFS)和总生存期(overall survival,OS)均大幅延长。对于患者的疗效而言,传统意义的评效标准完全缓解(complete response,CR)已经不能满足其对预后的指导,微小残留病(minimal residual disease,MRD)的评估应运而生,其检测方法发展较快。血清游离轻链(serum free light chain,sFLC)、流式细胞术、聚合酶链式反应(polymerase chain reaction,PCR)、二代测序(next-generation sequencing,NGS)和PET-CT等各项技术层出不穷。本文就上述各检测手段在MM移植后患者中的应用现状予以综述。 展开更多
关键词 多发性骨髓瘤 移植 微小残留病 流式细胞术 二代测序
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The configuration of Au^(δ+)-ZrO_(2)^(δ−)species induced activation enhances electrocatalytic CO_(2)to formate conversion
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作者 Yongjian Jia Yadi Zhang +2 位作者 Mengque Lin Yangyang Cheng yanjie xu 《Nano Research》 SCIE EI CSCD 2024年第7期6006-6015,共10页
Electrochemical CO_(2)conversion into value-added chemicals is a promising technology to solve the greenhouse effect and recycle chemical energy.However,the electrochemical CO_(2)reduction reaction(e-CO_(2)RR)is serio... Electrochemical CO_(2)conversion into value-added chemicals is a promising technology to solve the greenhouse effect and recycle chemical energy.However,the electrochemical CO_(2)reduction reaction(e-CO_(2)RR)is seriously compromised by weak CO_(2)adsorption and a rough CO_(2)activation process based on the chemical inertness of the CO_(2)molecule and the formed fragile metal–C/O bond.In this paper,we designed and fabricated Au particles embedded in ZrO_(2).The configuration of Au particles being of positive charge and ZrO_(2)with negative charge is induced and generated by metal–support interactions(MSIs).As a result,Au/ZrO_(2)@C presents a big difference in the CO_(2)conversion compared with the known work,affording a formate yield of 112.5μmol·cm^(−2)·h^(−1)at−1.1 V vs.reversible hydrogen electrode(RHE),and a max formate Faradaic efficiency of up to 94.1%at−0.9 V vs.RHE.This superior performance was attributed to the activated Au–ZrO_(2)interface to form the Au^(δ+)species.Both insitu Fourier transform infrared(FTIR)spectroscopy and theoretical calculations show that the MSIs configuration can be inclined to the*OCO intermediate generation on Au^(δ+)species activating CO_(2)molecules and then accelerate the formation of the*OCHO intermediate in e-CO_(2)RR,thereby favoring the CO_(2)conversion to formate. 展开更多
关键词 electrochemical CO_(2)reduction reaction(e-CO_(2)RR) Au_(δ+)species formic acid *OCHO intermediate metal-support interactions
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多媒体式术前访视在日间腹腔镜腹股沟疝手术患者的应用效果 被引量:1
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作者 郭劲峰 徐艳杰 +1 位作者 向承红 刘伟 《中华疝和腹壁外科杂志(电子版)》 2022年第5期605-607,共3页
目的研究多媒体式术前访视在日间腹腔镜腹股沟疝手术的效果。方法选择2021年2-9月首都医科大学附属北京朝阳医院在日间手术模式下行腹腔镜腹股沟疝患者160例,采用抽签法平均分为对照组和研究组。对照组提供常规术前访视,研究组提供多媒... 目的研究多媒体式术前访视在日间腹腔镜腹股沟疝手术的效果。方法选择2021年2-9月首都医科大学附属北京朝阳医院在日间手术模式下行腹腔镜腹股沟疝患者160例,采用抽签法平均分为对照组和研究组。对照组提供常规术前访视,研究组提供多媒体式术前访视,评估两种不同访视方式的效果,对比两组患者术前焦虑程度,入室后平均动脉压、心率值的变化程度,调查患者术后满意度。结果焦虑程度研究组得分(34.35±1.40)分明显优于对照组(42.58±2.08)分,差异有统计学意义(P<0.05)。平均动脉压和心率升高值研究组(12.01±1.06)mmHg、(8.1±0.73)次/min优于对照组(17.95±1.26)mmHg、(13.7±1.21)次/min;手术满意度研究组(97.85±0.27)分优于对照组(95.11±0.45)分,差异均有统计学意义(P<0.001)。结论在日间手术模式下应用多媒体进行术前访视能够减轻患者术前焦虑,降低因为不良心理状态引起的应激反应从而降低手术风险,提高患者手术满意度,加快日间手术周转。 展开更多
关键词 腹股沟 腹腔镜 疝修补术 日间手术 多媒体
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Seismic damage-cracking analysis of arch dams using different earthquake input mechanisms 被引量:19
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作者 JianWen Pan ChuHan Zhang +1 位作者 JinTing Wang yanjie xu 《Science China(Technological Sciences)》 SCIE EI CAS 2009年第2期518-529,共12页
In this study, a nonlinear model is presented for analysis of damage-cracking behavior in arch dams during strong earthquakes using different seismic input mechanisms. The nonlinear system includes a plastic-damage mo... In this study, a nonlinear model is presented for analysis of damage-cracking behavior in arch dams during strong earthquakes using different seismic input mechanisms. The nonlinear system includes a plastic-damage model for cyclic loading of concrete considering strain softening and a contact boundary model of contraction joint opening. Two different earthquake input mechanisms are used for comparison, including massless foundation input model and viscous-spring boundary model considering radiation damping due to infinite canyon. The results demonstrate that effects of seismic input mechanism and radiation damping on nonlinear response and damage-cracking of the dam are significant. Compared with the results of using massless foundation input model, the damage-cracking region and contraction joint opening are substantially reduced when using viscous-spring boundary model to take into account radiation damping. However, if the damping ratio of the dam is artificially increased to about 10%―15% for massless foundation input model, the joint opening and damage-cracking of the dam are comparable to the results obtained from the viscous-spring boundary model. 展开更多
关键词 EARTHQUAKE input mechanism damage-cracking radiation DAMPING CONTRACTION JOINTS ARCH DAM
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CmNF-YB8 affects drought resistance in chrysanthemum by altering stomatal status and leaf cuticle thickness 被引量:3
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作者 Tianle Wang Qian Wei +6 位作者 Zhiling Wang Wenwen Liu Xin Zhao Chao Ma Junping Gao yanjie xu Bo Hong 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2022年第3期741-755,共15页
Drought is a major abiotic stress that limits plant growth and development.Adaptive mechanisms have evolved to mitigate drought stress,including the capacity to adjust water loss rate and to modify the morphology and ... Drought is a major abiotic stress that limits plant growth and development.Adaptive mechanisms have evolved to mitigate drought stress,including the capacity to adjust water loss rate and to modify the morphology and structure of the epidermis.Here,we show that the expression of CmNF-YB8,encoding a nuclear factor Y(NF-Y)B-type subunit,is lower under drought conditions in chrysanthemum(Chrysanthemum morifolium).Transgenicchrysanthemumlinesinwhich transcript levels of CmNF-YB8 were reduced by RNA interference(CmNF-YB8-RNAi)exhibited enhanced drought resistance relative to control lines,whereas lines overexpressing CmNF-YB8(CmNF-YB8-OX)were less tolerant to drought.Compared to wild type(WT),CmNF-YB8-RNAi plants showed reduced stomatal opening and a thicker epidermal cuticle that correlated with their water loss rate.We also identified genes involved in stomatal adjustment(CBLinteracting protein kinase 6,CmCIPK6)and cuticle biosynthesis(CmSHN3)that are more highly expressed in CmNF-YB8-RNAi lines than in WT,CmCIPK6 being a direct downstream target of CmNF-YB8.Virus-induced gene silencing of CmCIPK6 or CmSHN3 in the CmNFYB8-RNAi background abolished the effects of CmNF-YB8-RNAi on stomatal closure and cuticle deposition,respectively.CmNF-YB8 thus regulates CmCIPK6 and CmSHN3 expression to alter stomatal movement and cuticle thickness in the leaf epidermis,thereby affecting drought resistance. 展开更多
关键词 Chrysanthemum morifolium cuticle drought stress NF-YB8 stomatal status
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An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines
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作者 Dandan Shen yanjie xu +6 位作者 Dong He Jing Han Jie Chen Hongmei Deng Min Shao Hui Zhang Weiguo cao 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2016年第5期524-532,共9页
A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. M... A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mild condition. The structures of perfluoroalkylated quinolizine derivatives were char- acterized by means of IH NMR, 13C NMR, 19F NMR, IR, LRMS and HRMS. Furthermore, the reaction mechanism was proposed. 展开更多
关键词 QUINOLIZINES perfluoroalkylated MULTI-COMPONENT one-pot reaction
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