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中晚期肝癌TACE联合免疫靶向转化治疗后右半肝切除术一例 被引量:1
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作者 宋燕京 乔江春 宋京海 《中华肝脏外科手术学电子杂志》 CAS 2024年第2期227-230,共4页
患者男,41岁,因"右上腹胀痛1月余"于2021年9月26日入院。当地医院腹部CT检查示肝右叶占位性病变,入院前肝占位穿刺活检,病理检查示肝细胞癌(肝癌)。患者既往有慢性乙型病毒性肝炎(乙肝)病史15年,口服抗病毒药物规律治疗,其余... 患者男,41岁,因"右上腹胀痛1月余"于2021年9月26日入院。当地医院腹部CT检查示肝右叶占位性病变,入院前肝占位穿刺活检,病理检查示肝细胞癌(肝癌)。患者既往有慢性乙型病毒性肝炎(乙肝)病史15年,口服抗病毒药物规律治疗,其余既往史及个人史无特殊。入院查体:右上腹轻叩痛,余未见明显异常。入院完善辅助检查,实验室指标:RBC 3.69×10^(12)/L,WBC 9.72×10^(9)/L,中性粒细胞百分率75%,TB 17.1 μmol/L,DB 7.8 μmol/L,AST 51 U/L,ALT 49 U/L,TP 63 g/L,ALB 31 g/L,PT 14.4 s,AFP 14.4 μg/L,HBsAg(+),HBV-DNA定量未测,肝功能Child-Pugh分级A级。腹部增强CT检查示肝右叶不均匀强化肿块影,范围约为10.1 cm×7.3 cm×12.1 cm,门静脉右支及分支管腔内见多发低密度充盈缺损影,肝门区见稍肿大淋巴结影,余腹膜后见多发小淋巴结(图1a)。MRI平扫示右半肝一巨大肿块影,以肝Ⅵ、Ⅶ段为主,较大截面大小约9.1 cm×7.8 cm,分叶状,似多结节融合,T1WI呈低信号,T2WI呈混杂稍高信号,弥散加权成像(DWI)呈高信号,表现弥散系数(apparent diffusion coefficient,ADC)值减低,门静脉右支增粗,内见类似信号(图1b)。患者入院诊断为肝癌、慢性乙肝、肝硬化,CNLCⅢa期。 展开更多
关键词 肝细胞 经导管动脉化疗栓塞(TACE) 免疫治疗 靶向治疗 转化治疗 右半肝切除术
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Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo 被引量:14
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作者 yanjing song Chuan Tong +8 位作者 Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen 《Protein & Cell》 SCIE CAS CSCD 2018年第10期867-878,共12页
Human epidermal growth factor receptor 2 (HER2) pro- teins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cancer stem cell (CSC) subpopulations, which are used ... Human epidermal growth factor receptor 2 (HER2) pro- teins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cancer stem cell (CSC) subpopulations, which are used as tar- gets for the clinical treatment of patients with HER2- positive GC. Despite improvements in survival, numer- ous HER2-positive patients fail treatment with trastuzu- mab, highlighting the need for more effective therapies. In this study, we generated a novel type of genetically modified human T cells, expressing a chimeric antigen receptor (CAR), and targeting the GC cell antigen HER2, which harbors the CD137 and CD3/; moieties. Our findings show that the expanded CART cells, expressing an increased central memory phenotype, were activated by the specific recognition of HER2 antigens in an MHC-in- dependent manner, and effectively killed patient-derived HER2-positive GC cells. In HER2-positive xenograft tumors, CART cells exhibited considerably enhanced tumor inhibition ability, long-term survival, and homing totargets, compared with those of non-transduced T cells. The sphere-forming ability and in vivo tumorigenicity of patient-derived gastric cancer stem-like cells, expressing HER2 and the CD44 protein, were also inhibited. Our results support the future development and clinical application of this adoptive immunotherapy in patients with HER2-positive advanced GC. 展开更多
关键词 chimeric antigen receptor HER2 gastriccancer cancer stem cell CD137 IMMUNOTHERAPY
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