Pests detecting is an important research subject in grain storage field.In the past decades,many edge detection methods have been applied to the edge detection of stored grain pests.Although some of them can realize t...Pests detecting is an important research subject in grain storage field.In the past decades,many edge detection methods have been applied to the edge detection of stored grain pests.Although some of them can realize the stored grain pests detecting,precision and robustness are not good enough.Spectral residual(SR)saliency edge detection defines the logarithmic spectrumof image as novelty part of the image information.The remaining spectrumis converted to the airspace to obtain edge detection results.SR algorithm is completely based on frequency domain processing.It not only can effectively simplify the target detection algorithm,but also can improve the effectiveness of target recognition.The experimental results show that the edge results of stored grain pests detected by SR method are effective and stable.展开更多
Mesoporous GdPO4:Eu@SiO2@mSiO2 core-shell nanorods(NRs) were prepared by a facile two-step method.First,the monodispersed GdPO4:Eu NRs were obtained on a large scale via a facile precipitation method,then mesoporous s...Mesoporous GdPO4:Eu@SiO2@mSiO2 core-shell nanorods(NRs) were prepared by a facile two-step method.First,the monodispersed GdPO4:Eu NRs were obtained on a large scale via a facile precipitation method,then mesoporous silica was wrapped onto their surface through hydrolysis of tetraethylorthosilicate(TEOS).The XRD result indicates that the as-prepared GdPO4:Eu NRs core has hexagonal phase.The FTIR and the N2 adsorption/desorption isotherm analysis confirm the successful coating of mesoporous silica.The TEM images show that the obtained GdPO4:Eu@SiO2@mSiO2 NRs exhibit uniform monodisperse core-shell structure with a nanorod core(length of 200 nm;width of 20 nm),and mesoporous silica shell of 15 nm.Under excitation of 274 nm,GdPO4:Eu@SiO2@mSiO2 NRs show strong red luminescence from 5 D0→7 FJ(J=1,2,3 and 4) transitions of Eu3+.Furthermore,the GdPO4:Eu@-SiO2@mSiO2 NRs exhibit obvious T1 enhancement effect due to paramagnetism of Gd3+.The drug loading capacity and pH-sensitive releasing behavior of the as-prepared GdPO4:Eu@SiO2@mSiO2 NRs were studied by using doxorubicin(DOX) as model drug.The excellent biocompatibility of GdPO4:Eu@-SiO2@mSiO2 NRs was demonstrated by MTT assay.Taken together,the mesoporous GdPO4:Eu@-SiO2@mSiO2 NRs may be potentially applied in fields of drug delivery and dual-modal imaging.展开更多
To the Editor:Proteolysis Targeting Chimera(PROTAC)is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome.Since PROTACs can degrade target proteins without high affinity,it...To the Editor:Proteolysis Targeting Chimera(PROTAC)is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome.Since PROTACs can degrade target proteins without high affinity,it is natural to speculate that this technology can be used to identify the targets of natural products。Although a recent study reported the employment of PROTACs to explore the unknown non-kinase target of a multi-kinase inhibitor sorafenib,whether PROTACs can be used to find the potential targets of natural products remains unexplored.展开更多
基金financially supported by National Natural Science Foundation of China(No.61871176)Key Scientific and Technological Project of Science and Technology Department of Henan Province(No.172102210030,182102110099)+2 种基金Key Scientific Research Project Program of Universities of Henan Province(No.18B520025)Open Fund of Key Laboratory of Grain Information Processing and Control(No.KFJJ-2018-102)supported by Collaborative Innovation Center of Grain Storage and Security of Henan Province
文摘Pests detecting is an important research subject in grain storage field.In the past decades,many edge detection methods have been applied to the edge detection of stored grain pests.Although some of them can realize the stored grain pests detecting,precision and robustness are not good enough.Spectral residual(SR)saliency edge detection defines the logarithmic spectrumof image as novelty part of the image information.The remaining spectrumis converted to the airspace to obtain edge detection results.SR algorithm is completely based on frequency domain processing.It not only can effectively simplify the target detection algorithm,but also can improve the effectiveness of target recognition.The experimental results show that the edge results of stored grain pests detected by SR method are effective and stable.
基金Project supported by the National Natural Science Foundation of China (21676131)the Natural Science Foundation of Jiangxi Province(20143ACB20012)。
文摘Mesoporous GdPO4:Eu@SiO2@mSiO2 core-shell nanorods(NRs) were prepared by a facile two-step method.First,the monodispersed GdPO4:Eu NRs were obtained on a large scale via a facile precipitation method,then mesoporous silica was wrapped onto their surface through hydrolysis of tetraethylorthosilicate(TEOS).The XRD result indicates that the as-prepared GdPO4:Eu NRs core has hexagonal phase.The FTIR and the N2 adsorption/desorption isotherm analysis confirm the successful coating of mesoporous silica.The TEM images show that the obtained GdPO4:Eu@SiO2@mSiO2 NRs exhibit uniform monodisperse core-shell structure with a nanorod core(length of 200 nm;width of 20 nm),and mesoporous silica shell of 15 nm.Under excitation of 274 nm,GdPO4:Eu@SiO2@mSiO2 NRs show strong red luminescence from 5 D0→7 FJ(J=1,2,3 and 4) transitions of Eu3+.Furthermore,the GdPO4:Eu@-SiO2@mSiO2 NRs exhibit obvious T1 enhancement effect due to paramagnetism of Gd3+.The drug loading capacity and pH-sensitive releasing behavior of the as-prepared GdPO4:Eu@SiO2@mSiO2 NRs were studied by using doxorubicin(DOX) as model drug.The excellent biocompatibility of GdPO4:Eu@-SiO2@mSiO2 NRs was demonstrated by MTT assay.Taken together,the mesoporous GdPO4:Eu@-SiO2@mSiO2 NRs may be potentially applied in fields of drug delivery and dual-modal imaging.
基金supported by National Natural Science Foundation of China (NSFC) (No. 82141216)Chunhui Program-Cooperative Research Project of the Ministry of Education, Liaoning Province Natural Science Foundation (No. 2020-MZLH-31, China)Shenyang Young and Middle-aged Innovative Talents Support Program (RC210446, China)
文摘To the Editor:Proteolysis Targeting Chimera(PROTAC)is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome.Since PROTACs can degrade target proteins without high affinity,it is natural to speculate that this technology can be used to identify the targets of natural products。Although a recent study reported the employment of PROTACs to explore the unknown non-kinase target of a multi-kinase inhibitor sorafenib,whether PROTACs can be used to find the potential targets of natural products remains unexplored.