Ascidian-derived microorganisms are a signifcant source of pharmacologically active metabolites with interesting structural properties.When discovering bioactive molecules from ascidian-derived fungi,two new phenols,r...Ascidian-derived microorganisms are a signifcant source of pharmacologically active metabolites with interesting structural properties.When discovering bioactive molecules from ascidian-derived fungi,two new phenols,roussoelins A(1)and B(2),and ten known polyketides(3–12)were isolated from the ascidian-derived fungus Roussoella siamensis SYSU-MS4723.The planar structure of compounds 1 and 2 was established by analysis of HR-ESIMS and NMR data.The conformational analysis of the new compounds was assigned according to coupling constants and selective gradient NOESY experiments,and absolute confgurations were completed by the modifed Mosher’s method.Among the isolated compounds,1,2,and 9 showed moderate antioxidant capacity.展开更多
基金We thank the National Natural Science Foundation of China[Grant no.41806155]Guangdong MEPP Fund[no.GDOE(2019)A21]the Natural Science Foundation of Guangdong Province,China(2018A030310304)for generous support.
文摘Ascidian-derived microorganisms are a signifcant source of pharmacologically active metabolites with interesting structural properties.When discovering bioactive molecules from ascidian-derived fungi,two new phenols,roussoelins A(1)and B(2),and ten known polyketides(3–12)were isolated from the ascidian-derived fungus Roussoella siamensis SYSU-MS4723.The planar structure of compounds 1 and 2 was established by analysis of HR-ESIMS and NMR data.The conformational analysis of the new compounds was assigned according to coupling constants and selective gradient NOESY experiments,and absolute confgurations were completed by the modifed Mosher’s method.Among the isolated compounds,1,2,and 9 showed moderate antioxidant capacity.
