Efficacy of patient-controlled hydromorphone analgesia in those undergoing uterine fibroid artery embolization via the right radial artery

Objective: To evaluate the efficacy and safety of patient-controlled analgesia(PCA) with hydromorphone as perioperative analgesia during uterine artery embolization(UAE) via the right radial artery.Patients and methods: A total of 33 patients with uterine fibroids, who underwent UAE at the authors’ hospital between June 2021 and March 2022, were selected. Hydromorphone(10 mg) was dispensed into a 100 ml PCA pump with normal saline. Pump administration was initiated 15 min before the start of the procedure, and the intraoperative dose was adjusted according to patient pain level. A numerical rating scale was used to evaluate pain immediately after embolization, 5 min after embolization, at the end of the procedure, and 6, 12, 24, 48, and 72 h after the procedure. Side effects were also observed.Results: Thirty-three patients underwent uterine artery embolization via the right radial artery. Patient pain was well controlled at all time points surveyed, and patients reported satisfaction with analgesia. The median length of hospital stay was 5 days. There were 7 cases of adverse reactions, but no serious side effects were observed.Conclusion: Patients reported positive experiences with arterial embolization of uterine fibroids via the right radial artery. Hydromorphone PCA effectively controlled pain. The PCA pump is easy to operate, has a low incidence of adverse reactions, and offers economic benefits at the patient and institutional levels.

超临界CO_(2)增稠剂研究进展

超临界CO_(2)压裂是开发利用非常规油气资源的有效手段之一,然而超临界CO_(2)的低黏度特性导致了携沙性差和滤失量大的问题,超临界CO_(2)增稠剂的研发是解决此项问题的必要措施。文中将已报道的超临界CO_(2)增稠剂研究分为含氟类、聚硅氧烷类和烃类3种CO_(2)增稠剂,并进行了系统的研究分析,总结了超临界CO_(2)增稠剂分子设计思路。得出CO_(2)增稠剂分子设计原则:(1)从基团功能方向设计,新型CO_(2)增稠剂应由亲CO_(2)基团和CO_(2)增稠基团构成,保证增稠剂具备一定的CO_(2)溶解性和增稠性;(2)基团自身属性方向设计,基团自身主链应具有较好的柔顺性、低内聚能和较高的混合自由能。在超临界CO_(2)增稠剂的研究中,不仅要关注聚合物的溶解性与增稠性能,还可引入纳米材料这类新型材料来扩充超临界CO_(2)增稠剂分子的研究思路。

不同纤维源日粮对猪肠道菌群影响的研究进展

猪只日粮中添加纤维会在一定程度上降低营养物质的吸收效率,但是饲粮纤维可在猪只肠道后端进行一定程度的发酵,并产生大量的挥发性脂肪酸,具备了一定的营养作用。同时,也因此而降低猪只肠道pH,影响肠道菌群丰度及菌群结构。通过改变纤维日粮的组成来影响肠道中的菌群,发挥肠道上皮屏障功能,并且通过调节肠道微生物的组成来维持肠道微生物生态的稳定,是猪只肠道健康的关键控制点。肠道菌群与宿主相互协同,构成了肠道微生态系统,能够促进猪只对营养物质吸收利用。文章综述了不同纤维源日粮对猪只肠道菌群的影响,为养猪生产实践中应用不同纤维源提供一定理论依据。

影响旱地红壤易解吸磷的因子分析

在位于江西省鹰潭农田生态系统国家野外研究站内的肥料长期（始于1988年）定位试验中,选取了无机肥试验区的NPK和NK,有机肥试验区的对照（CK）、CK＋花生秸秆（SR）、CK＋绿肥（FR）、CK＋稻秆（RS）和CK＋猪厩肥（PM）等7个施肥处理.测定了长期施肥后旱地红壤中易解吸磷（Readily Desorbable Phosphorus,RDP）的含量,采用相关分析及通径分析方法,探讨了土壤pH及土壤有机质、铁铝氧化物、无机磷组分、黏粒等基质组分对红壤RDP的影响程度及其对红壤磷潜在淋失量的贡献率大小.结果表明：长期施肥的旱地红壤中RDP含量,随着土壤中有机质及各形态无机磷组分数量的增加而显著增加（p〈0.01）,却随着无定型氧化铁数量的增加而显著减少（p〈0.05）.通径分析进一步表明红壤各基本化学组分对RDP的直接贡献率（绝对值）大小依次为Al-P〉Fe-P〉Ca-P〉Oc-P〉游离氧化铁〉有机质〉游离氧化铝〉无定型氧化铁〉pH〉无定型氧化铝〉黏粒,可见,无机磷组分对旱地红壤RDP及磷素潜在流失量影响较大.因此,有效调控旱地红壤中Al-P、Fe-P、Ca-P的含量对降低土壤磷素的淋失及其对水体环境的污染具有重要作用.

我国幼儿教师专业发展政策的现状、问题和局限——基于对政策的内容分析

通过对幼儿教师专业发展政策文本的数量发展、权威部门构成、政策文本规范内容进行统计分析,发现我国幼儿教师专业发展受到教育管理部门高度重视、幼儿教师专业发展政策文本具有波动性、多权威控制性、复杂性等特点;推动幼儿教师专业发展的结果具有延时性。因此,作为幼儿教师专业发展政策制定主体的国家权威机构,在未来走制定政策走向中,一是要加强对幼儿教师专业发展政策决策的科学研究,尽量避免政策出台的随意性,二是要结合政策实际实施情况及时调整,确保政策执行的可操作性;三是实时跟踪政策实施效果,重视幼儿教师专业发展政策实施结果反馈的及时性和有效性。

Exogenous Melatonin Improves Physiological Characteristics and Promotes Growth of Strawberry Seedlings Under Cadmium Stress

Melatonin,as a plant growth regulator,is involved in plant stress resistance.We studied the effects of different concentrations(0,10,50,100,150,and 200μmol·L−1)of melatonin on the growth and physiological characteristics of strawberry under cadmium(Cd)stress.The results represented that the growth of strawberry seedlings was inhibited under Cd stress,and the seedling biomass,chlorophyll content and the activities of antioxidant enzymes such as superoxide dismutase(SOD),peroxidase(POD),catalase(CAT),and ascorbate peroxidase(APX)decreased.These toxic effects were,however,effectively remediated by exogenous melatonin pretreatment.Melatonin treatment slowed the inhibitory effect of seedling growth and significantly increased seedling biomass,chlorophyll content,antioxidant enzyme activities,and soluble protein levels in leaves and roots compared with the control.Melatonin treatment also reduced the malondialdehyde(MDA)content and the oxidative stress reactions,increased the anthocyanin content,and slowed the senescence rate,thereby reducing the toxic effects of Cd on strawberries.This indicates that foliar application of melatonin can effectively remediate the adverse effects of Cd on strawberry seedlings;the greatest effect was obtained with melatonin concentration of 100μmol·L−1.

Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres

A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres(GPcM)with different particle sizes were prepared with Guiqi polysaccharides(GP),chitosan(CS)and sodium alginate(Alg).The optimum preparation process was also determined by single factor and orthogonal experiment analysis.The GPcM were characterized by fourier transform infrared spectroscopy(FT-IR),scanning electron microscope(SEM),drug loading efficiency test(LE),encapsulation efficiency test(EE)and in vitro release study.The results showed that the Guiqi polysaccharides chitosan hydrogel(GPCH)and sodium alginate hydrogel(SAH)formed a crossover system in GPcM.The GPcM have a uniform particle size ranging from 395.1μm to 841.5μm.The drug loading efficiency and encapsulation efficiency of the GPcM were 56.3%and 72.6%,respectively.The bovine serum albumin(BSA)loaded in the GPcM released slowly within 180 h.The results suggested that the GPcM may have potential application value in drug sustained and controlled release system.

Study on Multi-Objective Effect Evaluation System of Smart Grid Construction

This paper builds multi-objective effect evaluation indicator system of smart grid construction from five connotations including strong and reliable, clean and green, friendly and interactive, transparent and open, economical and effective, which is embodied in the power generation, transmission, transformation, distribution, consumption, dispatching and information communication platform of smart grid. Taking the construction of smart grid in a certain area of China as an example, this paper uses analytic hierarchy process (AHP) to make an empirical analysis on it, and makes a comprehensive and objective evaluation on its construction effect.

猪床垫料与“替抗”的诡辩

1概念解析随着我国畜牧业的飞速发展,畜禽粪便成了环境的最大污染源,对环境的污染愈发严重。为控制粪便污物的排放,创造良好的生态养殖条件,国家大力推广发酵床养殖技术,发酵床主要是由有机垫料组成,垫料原料通常包括秸秆、锯末、木屑等,将其平铺与猪舍内,猪养于其上,排泄物排至垫料上,经微生物发酵,可实现粪污的低排放、低污染[1-2]。

The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment

Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transduction.Studies have shown that abnormal lipid metabolism is involved in many malignant processes,including colorectal cancer(CRC).Lipid metabolism in CRC cells can be regulated not only by intracellular signals,but also by various components in the tumor microenvironment,including various cells,cytokines,DNA,RNA,and nutrients including lipids.In contrast,abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells.In this review,we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.

Halloysite‒gold core‒shell nanosystem synergistically enhances thermal conductivity and mechanical properties to optimize the wear-resistance of a pheonlic-PBO/PTFE textile composite liner

Polymer-textile liner composites have potential applications in aerospace applications for reducing the abrasion damage of moving parts during operation owing to their self-lubrication,light weight,and high loading capacity.Herein,Au nanoparticles(AuNPs)are successfully loaded into the lumen of halloysite nanotubes(HNTs)to construct an HNTs‒Au peasecod core‒shell nanosystem to optimize the wear resistance of phenolic resin-based poly(p-phenylene benzobisoxazole)(PBO)/polytetrafluoroethylene(PTFE)textile composites.Transmission electron microscope(TEM)characterization reveals that the AuNPs are well-dispersed inside the HNTs,with an average diameter of 6‒9 nm.The anti-wear performance of the HNTs and Au-reinforced PBO/PTFE composites is evaluated using a pin-on-disk friction tester at 100 MPa.Evidently,the addition of HNTs‒Au induces a 27.9%decrease in the wear rate of the composites.Possible anti-wear mechanisms are proposed based on the analyzed results of the worn surface morphology and the cross-section of the tribofilm obtained by focused ion beam transmission electron microscopy.

Synergistically assembled RGO/Si_(3)N_(4) whiskers hybrid aerogels to endow epoxy composites with excellent thermal and tribological performance

Epoxy resin(EP)composites with satisfactory thermal and tribological performance are highly required for engineering moving components.However,the simple addition of fillers leaded to the serious filler agglomeration and limited promotion in tribological properties.In this work,we constructed a new kind of three-dimensional(3D)reduced graphene oxide(RGO)/Si_(3)N_(4) hybrid aerogel for EP composites,which was prepared by a facile hydrothermal self-assembly method followed by freeze-drying technique.As a result,the dispersibility of Si_(3)N_(4) whiskers was greatly improved through wrapping of polydopamine–polyethyleneimine copolymer(PDA–PEI)copolymer and physical spacing of 3D skeleton.Furthermore,benefiting from the synergistic effect of RGO and Si_(3)N_(4)@PDA–PEI in the thermal network,the thermal conductivity of RGO/Si_(3)N_(4) hybrid aerogel(GSiA)–EP increased by 45.4%compared to that of the neat EP.In addition,the friction coefficient and wear rate of GSiA–EP decreased by 83.7%and 35.8%,respectively.This work is significant for opening a tribological performance enhancement strategy though constructing 3D hybrid architecture.

北京市三级甲等医院临床护士跨专业合作学习准备度和感知度的调查分析

目的了解临床护士跨专业合作学习准备度和感知度的情况,为开展跨专业合作学习提供依据。方法采取方便取样法,运用中文版跨专业合作学习准备度量表和中文版跨专业合作学习感知度量表,调查北京市3所三级甲等医院不同临床科室的615名护士。结果调查对象中只有179人(29.1%)有过跨专业合作学习的经历,跨专业合作学习准备度和感知度分别为(76.00±10.18)分和(57.19±9.82)分,处于较高水平。跨专业合作学习准备度的影响因素有跨专业学习感知度、跨专业学习次数、性别及学历。结论临床护士对跨专业合作总体表现出积极的态度,可以在临床工作中开展跨专业合作学习。

高度近视萎缩弧面积的多模态成像定量分析

目的:比较高度近视患者萎缩弧(PPA)面积的多模态成像定量分析结果。方法:系列病例研究。收集2016年10月至2017年10月在首都医科大学附属北京友谊医院就诊的高度近视伴萎缩弧的患者30例(45眼)。其中,男13例(19眼),女17例(26眼)。年龄27~69(53.1±11.6)岁。所有患者均行眼底彩色照相(CFP)、近红外自发荧光(NIR-FAF)、眼底荧光素血管造影(FFA)及频域光学相干断层扫描(OCT)检查。由2名眼科医师在相互独立、互不干扰的情况下分别对上述多模态成像图像进行精准定量分析。采用Image J 1.50i版软件描绘并计算CFP、FAF、FFA图像中PPA的面积。当NIR-FAF难以确定视盘和PPA边界时,用频域OCT辅助确定。医师之间多模态成像结果的一致性检验采用Bland-Altman分析。结果:CFP、NIR-FAF、FFA检查测得患眼PPA面积分别为(7.1±4.7)mm2、(8.3±5.8)mm2、(8.1±5.5)mm2。CFP、FAF、FFA 3种方法测得PPA面积差异无统计学意义(F=1.193,P=0.307)。Bland-Altman分析结果显示,2名眼科医师之间多模态成像结果的一致性较高,其变异范围CFP<NIR-FAF<FFA。结论:NIR-FAF测得高度近视PPA面积最大,FFA次之,CFP最小。

Anti-fertility effect of levonorgestrel and quinestrol in Brandt’s voles(Lasiopodomys brandtii)

The combination of levonorgestrel and quinestrol(EP-1)has been shown to have anti-fertility effects on several wild rodents,but the mechanism underlying these effects is poorly understood.We investigated the effects of EP-1 and each of its components,levonorgestrel(P)and quinestrol(E),on the fertility of Brandt’s voles(Lasiopodomys brandtii)by using a gastric gavage method.The doses for EP-1,E and P were 1,0.34 and 0.66 mg/kg body weight,respectively.Male voles(n=98)were treated daily for 5 or 14 days,then the testes and epididymides were collected,weighed and examined histologically at 30(D30),60(D60)or 90(D90)days after the end of treatment.Four males were allowed to mate with normal females at D90.Female voles(n=75)were treated for 3 days and a further 3 days after a 7-day interval.The uteri and ovaries were weighed and examined histologically at 15(D15),30(D30)or 75(D75)days after the end of treatment.Each of three females were mated with fertile males at D30 and D75,respectively.Our results indicated that quinestrol(E)significantly decreased the sperm numbers in the testes as well as the weight of the testes and epididymides,with both of these tissues showing obvious structural abnormalities,and significantly reduced the litter size and the pup weight for females mated with males of the E treatment group.For female voles,treatment with E,P or EP-1 resulted in no marked influence on the fertility status.These data indicate that quinestrol(E)alone has a significant anti-fertility effect on male Brandt’s voles,but is ineffective in combination with levonorgestrel(P).

Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton

Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could

Boosting energy storage performance of low-temperature sputtered CaBi_(2)Nb_(2)O_(9) thin film capacitors via rapid thermal annealing

CaBi_(2)Nb_(2)O_(9) thin film capacitors were fabricated on SrRuO_(3)-buffered Pt(111)/Ti/Si(100)substrates by adopting a two-step fabrication process.This process combines a low-temperature sputtering deposition with a rapid thermal annealing(RTA)to inhibit the grain growth,for the purposes of delaying the polarization saturation and reducing the ferroelectric hysteresis.By using this method,CaBi_(2)Nb_(2)O_(9) thin films with uniformly distributed nanograins were obtained,which display a large recyclable energy density Wrec≈69 J/cm^(3) and a high energy efficiencyη≈82.4%.A superior fatigue-resistance(negligible energy performance degradation after 10^(9) charge-discharge cycles)and a good thermal stability(from-170 to 150℃)have also been achieved.This two-step method can be used to prepare other bismuth layer-structured ferroelectric film capacitors with enhanced energy storage performances.

Flow synthesis of a novel zirconium-based UiO-66 nanofiltration membrane and its performance in the removal of p-nitrophenol from water

In this work,a thin zirconium-based UiO-66 membrane was successfully prepared on an alumina hollow fiber tube by flow synthesis,and was used in an attempt to remove p-nitrophenol from water through a nanofiltration process.Two main factors,including flow rate and synthesis time,were investigated to optimize the conditions for membrane growth.Under optimal synthesis conditions,a thin UiO-66 membrane of approximately 2 um in thickness was fabricated at a flow rate of4 mL.h for 30 h.The p-nitrophenol rejection rate for the as-prepared UiO-66 membrane applied in the removal of p-nitrophenol from water was only 78.1%due to the existence of membrane defects caused by coordinative defects during membrane formation.Post-synthetic modification of the UiO-66 membrane was carried out using organic linkers with the same flow approach to further improve the nanofiltration performance.The result showed that the p-nitrophenol rejection for the post-modified membrane was greatly improved and reached over 95%.Moreover,the post-modified UiO-66 membrane exhibited remarkable long-term operational stability,which is vital for practical application.

Recovery of fertility in quinestrol-treated or diethylstilbestroltreated mice:Implications for rodent management

Fertility control is an alternative strategy to traditional culling for the management of rodent pests.Previous studies have demonstrated that quinestrol is a potential contraceptive for male rodents,but the recovery of fertility in quinestrol-treated rodents has not been evaluated.This study used C57BL/6J mice to evaluate the recovery rate of male fertility after the administration of quinestrol.Diethylstilbestrol(DES),a non-steroid estrogenic compound,was used for comparison.Different groups of mice were treated with 1 mg/kg quinestrol,1 mg/kg DES,or castor oil separately for 7 days.These mice were then killed on days 8,22 and 50 respectively.Our results indicated that the weight of epididymides and seminal vesicles decreased significantly on days 8 and 22 in quinestrol/DES-treated mice,with extensive histological changes in the seminiferous tubules.Sperm concentrations in the cauda epididymal fluid were significantly reduced on days 8 and 22 in both quinestrol and DES treatment groups and on day 50 for the DES,but not the quinestrol group.Further analysis revealed that DES-treated mice exhibited a higher proportion of abnormal sperm accumulation in the epididymis,indicating that the normal sperm transportation to the cauda epididymis was blocked.Our results indicate that the anti-fertility effects on male mice given quinestrol were of shorter duration than for those receiving DES at the dose of 1 mg/kg body weight.

The role of macrophage reprogramming induced by GRA15II,a polypeptide effector molecule of Toxoplasma gondii,in liver diseases in model mice

Toxoplasma gondii is a widespread parasite that may infect nearly all warm-blooded vertebrates.1 As an obligatory intracellular apicomplexan parasite,T.gondii has three different types of secretory organelles,including micronemes,rhoptries(ROP),and dense granules(GRAs),during invasion of host cells.2 Initially,the parasite replicates in a variety of host cell types as tachyzoites,especially in macrophages and dendritic cells(DCs).