Study on the Status Quo of Cultural Regeneration of Chongqing Bayu Culture in the Square Landscape

At present,with the acceleration of urbanization and the strong embedding of foreign cultures,traditional urban culture faces serious threats and disintegration.Cultural faults have become a common problem in Chinese cities.As one of the four centrally administered municipalities in China,Chongqing has a history of two thousand years.In recent years,with the development of modernization,Chongqing's original unique regional urban characteristics are gradually disappearing.This paper selects the most representative urban landscape of Chongqing as the research object.The purpose of this paper is to find out the phenomenon of cultural regeneration of Chongqing Bayu culture in modern landscape design,and to find out the method of cultural regeneration of traditional Bayu culture in modem landscape.In order to achieve this goal,this paper uses the research method of case investigation.First,select the landscape of the Three Gorges Square,which best represents the image of Chongqing city,for investigation.Then through the onthe-spot investigation,shooting records,conversation records and other forms,the investigation found out the phenomenon of the regeneration of Chongqing Bayu culture in the square landscape,and finally,by analyzing the phenomena appearing in the landscape of these Bayu cultures,the traditional methods of cultural regeneration in the modem landscape can be analyzed.

In situ triggering antitumor efficacy of alcoholabuse drug disulfiram through Cu-based metalorganic framework nanoparticles

Although approved as an alcohol-abuse drug,disulfiram(DSF)exhibited potential anticancer activity when chelated with copper(Cu).However,the low level of intrinsic Cu,toxicity originated from exogenous Cu supplementation,and poor stability of DSF in vivo severely limited its application in cancer treatment.Herein,we proposed an in situ DSF antitumor efficacy triggered system,taking advantages of Cu-based metal-organic framework(MOF).In detail,DSF was encapsulated into Cu-MOF nanoparticles(NPs)during its formation,and the obtained NPs were coated with hyaluronic acid to enhance the tumor targetability and biocompatibility.Notably,DSF loaded Cu-MOF NPs maintained stability and integrity without Cu;leakage in blood circulation,thus showing excellent biosafety.Once accumulating at tumor site,NPs were internalized into tumor cells via receptor-mediated endocytosis and released DSF and Cu;simultaneously in the hyaluronidase-enriched and acidic intracellular tumor microenvironment.This profile lead to in situ chelation reaction between DSF and Cu;,generating toxic DSF/Cu complex against tumor cells.Both in vitro and in vivo results demonstrated the programmed degradation and recombination property of Cu-based MOF NPs,which facilitated the tumor-specific chemotherapeutic effects of DSF.This system provided a promising strategy for the application of DSF in tumor therapy.

Growth factor regulatory system:a new system for not truly recognized organisms

Growth,development,aging,and disease occurrence in organisms,especially animals or Homo sapiens,are regulated by different regulatory systems in vivo.The nervous,endocrine,metabolic,and immune systems are the traditional biological systems essential for the growth,development,and metabolism of the body.These systems maintain a balance and precisely biologically regulate every aspect of life activities under normal circumstances.However,in abnormal situations,owing to endogenous or exogenous attack,these regulatory systems result in dysfunction,subsequently leading to illness or injury(Muggianu et al.,2018).In the classical neuroendocrine regulatory system,Cushing’s syndrome is defined as a series of abnormal clinical symptoms with chronic overproduction of glucocorticoids in the adrenal cortex.Its clinical manifestations are“moon face”and“buffalo hump,”involving blood circulation,bone metabolism,and gonadal function,among others.In addition,severe trauma or burn leads to an imbalanced immune regulatory system,resulting in excessive inflammatory reactions and sepsis.Thus,an independent or cooperative regulation of multiple regulatory systems is critical in maintaining the body’s homeostasis,healthy development,and growth.

The Association Between Epoxide Hydrolase Genetic Variant and Effectiveness of Nicotine Replacement Therapy in a Han Chinese Population

Dear Editor, Nicotine is a psychoactive alkaloid that is thought to play a key role in addiction to commercial tobacco products [1] and cotinine is its primary metabolite [2]. Pharmacological treatment, such as nicotine replacement therapy （NRT）, is a valid solution to this problem. Tobacco smoke contains many carcinogens such as nitrosamines .

Recent advancements in plasmon-enhanced visible light-driven water splitting

Recently,the combination of plasmonic noble metallic nanostructures with semiconductors for plasmonenhanced visible light-driven water splitting(WS)has attracted considerable attention.This review first presents three prime enhancement mechanisms for plasmon-enhanced photocatalytic WS,and then some state-of-the-art representative studies are introduced according to different enhancement mechanisms.Furthermore,the design parameters of plasmonic-metal/semiconductor photocatalysts are discussed in detail,focusing on the effect of shape,size and geometric position of metallic nanostructures on the photocatalytic activity of visible light-driven WS.Finally,the challenges and perspectives for plasmon-enhanced solar WS are proposed.