Inflammation plays an important role in the occurrence and development of many inflammatory diseases.The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting ...Inflammation plays an important role in the occurrence and development of many inflammatory diseases.The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins(PC)nanoparticles on lipopolysaccharide(LPS)-stimulated inflammatory macrophages by metabolomics method.The double-targeting PC nanoparticles could specifi cally target both the CD44 receptor and mitochondria,while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of macrophages.The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS.Amino acid metabolism,energy metabolism and purine metabolism were disordered in LPS-treated group,and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts.The changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation,and promote their application in nutrition intervention.展开更多
The two-dimensional (2D) Eshelby tensors are discussed. Based upon the complex variable method, an integrity basis of ten isotropic invariants of the 2D Eshelby tensors is obtained. Since an integrity basis is always ...The two-dimensional (2D) Eshelby tensors are discussed. Based upon the complex variable method, an integrity basis of ten isotropic invariants of the 2D Eshelby tensors is obtained. Since an integrity basis is always a polynomial functional basis, these ten isotropic invariants are further proven to form an irreducible polynomial functional basis of the 2D Eshelby tensors.展开更多
Third order three-dimensional symmetric and traceless tensors play an important role in physics and tensor representation theory. A minimal integrity basis of a third order three-dimensional symmetric and traceless te...Third order three-dimensional symmetric and traceless tensors play an important role in physics and tensor representation theory. A minimal integrity basis of a third order three-dimensional symmetric and traceless tensor has four invariants with degrees two, four, six, and ten, respectively. In this paper, we show that any minimal integrity basis of a third order three-dimensional symmetric and traceless tensor is also an irreducible function basis of that tensor, and there is no syzygy relation among the four invariants of that basis, i.e., these four invariants are algebraically independent.展开更多
基金supported by the National Science Fund for Distinguished Young Scholars of China(31925031).
文摘Inflammation plays an important role in the occurrence and development of many inflammatory diseases.The purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins(PC)nanoparticles on lipopolysaccharide(LPS)-stimulated inflammatory macrophages by metabolomics method.The double-targeting PC nanoparticles could specifi cally target both the CD44 receptor and mitochondria,while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of macrophages.The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS.Amino acid metabolism,energy metabolism and purine metabolism were disordered in LPS-treated group,and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts.The changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation,and promote their application in nutrition intervention.
基金Project supported by the National Natural Science Foundation of China(Nos.11271221,11771244,11571178,and 11771405)
文摘The two-dimensional (2D) Eshelby tensors are discussed. Based upon the complex variable method, an integrity basis of ten isotropic invariants of the 2D Eshelby tensors is obtained. Since an integrity basis is always a polynomial functional basis, these ten isotropic invariants are further proven to form an irreducible polynomial functional basis of the 2D Eshelby tensors.
基金National Natural Science Foundation of China (Grant Nos. 1177132& 11771405, 1157117& 11372124)Hong Kong Research Grant Council (Grant Nos. PolyU 15302114, 15300715, 15301716, 15300717).
文摘Third order three-dimensional symmetric and traceless tensors play an important role in physics and tensor representation theory. A minimal integrity basis of a third order three-dimensional symmetric and traceless tensor has four invariants with degrees two, four, six, and ten, respectively. In this paper, we show that any minimal integrity basis of a third order three-dimensional symmetric and traceless tensor is also an irreducible function basis of that tensor, and there is no syzygy relation among the four invariants of that basis, i.e., these four invariants are algebraically independent.
