The bimetallic NiCu/SAPO-11 catalysts were prepared by co-impregnation, sequential impregnation, coprecipitation, and mechanical mixing methods. Powder X-ray diffraction, nitrogen adsorption-desorption,temperature-pro...The bimetallic NiCu/SAPO-11 catalysts were prepared by co-impregnation, sequential impregnation, coprecipitation, and mechanical mixing methods. Powder X-ray diffraction, nitrogen adsorption-desorption,temperature-programmed desorption of ammonia, transmission electron microscopy, temperatureprogrammed reduction of hydrogen, and X-ray photoelectron spectroscopy were used to characterize the physicochemical properties of the catalysts. The catalytic performance of the catalysts was assessed by the hydroisomerization of n-octane. Results indicated that the conversion of n-octane and selectivity to n-octane isomers were related to the preparation methods of the catalysts. The catalysts with Ni-Cu alloy effectively restrained the hydrogenolysis reaction that decreases the selectivity of isomerization. The catalyst prepared by the mechanical mixing of NiO and CuO hardly formed Ni-Cu alloy, showing obvious hydrogenolysis and low selectivity to n-octane isomers. The unbalance between the metal and acid sites resulted in the low conversion of n-octane and selectivity to n-octane isomers. Among all the catalysts,the catalyst prepared by the co-impregnation method exhibited high catalytic activity and selectivity to n-octane isomers.展开更多
Whitefly-transmitted begomoviruses are economically important plant pathogens that cause severe problems in many crop plants,such as tomato,papaya,cotton,and tobacco.Tomato yellow leaf curl virus(TYLCV)is a typical mo...Whitefly-transmitted begomoviruses are economically important plant pathogens that cause severe problems in many crop plants,such as tomato,papaya,cotton,and tobacco.Tomato yellow leaf curl virus(TYLCV)is a typical monopartite begomovirus that has been extensively studied,but methods that can efficiently control begomoviruses are still scarce.In this study,we combined artificial microRNA(amiRNA)-mediated silencing technology and clay nanosheetmediated delivery by spraying and developed a method for efficiently preventing TYLCV infection in tomato plants.We designed three amiRNAs that target different regions of TYLCV to silence virus-produced transcripts.Three plant expression vectors expressing pre-amiRNAs were constructed,and recombinant plasmid DNAs(pDNAs)were loaded onto nontoxic and degradable layered double hydroxide(LDH)clay nanosheets.LDH nanosheets containing multiple pDNAs were sprayed onto plant leaves.We found that the designed amiRNAs were significantly accumulated in leaves 7 days after spraying,while the pDNAs were sustainably detected for 35 days after the spray,suggesting that the LDH nanosheets released pDNAs in a sustained manner,protected pDNAs from degradation and efficiently delivered pDNAs into plant cells.Importantly,when the LDH nanosheets coated with pDNAs were sprayed onto plants infected by TYLCV,both the disease severity and TYLCV viral concentration in sprayed plants were significantly decreased during the 35 days,while the levels of H_(2)O_(2) were significantly increased in those plants.Taken together,these results indicate that LDH nanosheets loaded with pDNAs expressing amiRNAs can be a sustainable and promising tool for begomovirus control.展开更多
Salinity and drought stress are major abiotic stresses negatively affecting the growth and productivity of alfalfa(Medicago sativa L.).Exploration of genes exhibiting superior tolerance to salinity and drought stress ...Salinity and drought stress are major abiotic stresses negatively affecting the growth and productivity of alfalfa(Medicago sativa L.).Exploration of genes exhibiting superior tolerance to salinity and drought stress in alfalfa will help aid target molecular breeding and developing tolerant forages.In this study,we adopted a high-efficient yeast FOX hunting system for the identification of salinity and drought tolerant genes in alfalfa.Based on the Gateway-compatible vector system,a high-quality expression library was constructed,containing 1.3×10^(7) clones with an average size of 1.44 kb.Through heterologous transformation of mixed library plasmid into salt or drought sensitive yeast mutants,monoclonal resistant strains were screened and tolerant genes were captured.Eighteen salinity-tolerance genes were obtained which were involved in several pathways,containing GRAS and zinc finger transcriptional factors,PP2A interaction module,ERVT vesicle transporter and LETM transmembrane protein.Twelve drought tolerance genes were separated,including ERF and SCL transcriptional factors,CIPK and BSK protein kinases,TGL-type ligase,cPGM and cPDL protease.The mRNA transcription levels of these tolerant genes were inducible or suppressible for response to salt or drought stress conditions following quantitative PCR detection,respectively.Furthermore,heterologous transformation of ERVT and CIPK11 can improve the salt and drought stress tolerance in Arabidopsis,which indicates the conservative function of the screening gene in yeast and Arabidopsis.Obtaining these candidate genes can provide new insights for future research with respect to plant salt and drought tolerance.展开更多
With the aging in whole world, it has become a great challenge to explore the relationship between the cognitive and behavioral performance of senile dementia and the underlying pathology of the brain. Alzheimer’s di...With the aging in whole world, it has become a great challenge to explore the relationship between the cognitive and behavioral performance of senile dementia and the underlying pathology of the brain. Alzheimer’s disease (AD) is a common age-related and progressive neurodegenerative disease characterized and one of the main causes of senile dementia. The pathogenesis and treatment mechanism of AD are not completely clear. In recent years, it has been found that the Gut microbiota (GM) disorder is related to nervous system diseases. The objective of this review is to summarize the etiology and pathogenyon the role of GM in the development of AD, metabolites of GM and the occurrence of AD, and GM, diabetes and occurrence of AD. Understanding the relationship between GM and AD will help provide possible interventions to improve the structure of GM and prevent AD through different treatments, and it may provide clinicians with a new and more effective way for early diagnosis, prevention and treatment of AD.展开更多
A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing.The compact size and large evanescent field of microfiber provide an excellent platform for the interac...A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing.The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical signal and ultrasound wave,exhibiting a high sensitivity of 3.5 mV/kPa,which is approximately 10 times higher than the single-mode fiber sensor.Meanwhile,a phase feedback stabilization module is introduced into the coherent demodulation system for long-term stable measurement.In addition,a photoacoustic tomography experiment with the microfiber ultrasound sensor is implemented to verify the excellent performance on imaging,with the depth of 12 mm,the highest lateral resolution of 65μm and axial resolution of 250μm,respectively.The highly sensitive microfiber ultrasound sensor provides a competitive alternative for various applications,such as industrial non-destructive testing,biomedical ultrasound and photoacoustic imaging.展开更多
Target micromotion not only plays an important role in target recognition but also leads to esoteric characteristics in synthetic aperture radar (SAR) imaging. This paper finds out an interesting phenomenon, i.e. th...Target micromotion not only plays an important role in target recognition but also leads to esoteric characteristics in synthetic aperture radar (SAR) imaging. This paper finds out an interesting phenomenon, i.e. the angular extent effect, in micro-motion target images formulated by the polar format algorithm. A micromotion target takes on multiple pairs of paired echoes (PEs) around the true point, and each PE extends for an angle which is exactly equal to the angular extent of the synthetic aperture, regardless of the micromotion frequency. The effect is derived and interpreted by using the characteristics of Bessel functions. Then it is demonstrated by simulation experiments of a target with different micromotion frequencies. The revelation and interpretation of the effect is highly beneficial to micromotion-target SAR image understanding as wel as target recognition.展开更多
In this paper,we report a facile strategy to synthesize Co-BDC-NH2 material,which is used as a precursor towards an excellent OER electrocatalyst by thermal annealing in nitrogen.Ultra-small Co/Co Oxnanoparticles were...In this paper,we report a facile strategy to synthesize Co-BDC-NH2 material,which is used as a precursor towards an excellent OER electrocatalyst by thermal annealing in nitrogen.Ultra-small Co/Co Oxnanoparticles were uniformly dispersed on the rhombus N-doped carbon(NC)nanoflakes.Transmission electron microscopic,X-ray diffraction spectrometric,and X-ray photoelectron spectroscopic analyses revealed the coexistence of metallic Co and Co oxides nanoparticles.It was found that Co/CoO_(x)@NC obtained at 500℃ annealing temperature exhibited the highest electrocatalytic OER activity,with 307 and375 m V overpotential to achieve 10 and 100 m A cm^(-2) current densities.Besides,thanks to the in-situ annealing process,Co/CoO_(x)@NC showed excellent catalytic stability with 97.4%current density retention after 24 h electrolysis at 1.66 V vs.RHE electrode potential.Further investigations revealed that the ultrasmall Co/Co Oxnanoparticles distributed on N-doped carbon template contribute significantly towards OER electrocatalysis through enlarging the activity surface areas and enhancing the intrinsic electrochemical activity due to the presence of metallic Co.展开更多
The development of low-cost, efficient, and high atomic economy electrocatalysts for hydrogen evolution reaction(HER) in the entire p H range for sustainable hydrogen production is of great importance but still challe...The development of low-cost, efficient, and high atomic economy electrocatalysts for hydrogen evolution reaction(HER) in the entire p H range for sustainable hydrogen production is of great importance but still challenging. Herein, we synthesize a highly dispersed N-doped carbon frames(NCFs) anchored with Co single atoms(SAs) and Co nanoparticles(NPs) catalyst by a doping-adsorption-pyrolysis strategy for electrocatalytic hydrogen evolution. The Co SAs-Co NPs/NCFs catalyst exhibits an excellent HER activity with small overpotential, low Tafel slope, high turnover frequency as well as remarkable stability. It also exhibits a superior HER performance in the entire p H range. Combining with experimental and theoretical calculation, we find that Co SAs with Co-N_(3) coordination structure and Co NPs have a strong interaction for promoting synergistic HER electrocatalytic process. The H_(2)O molecule is easily activated and dissociated on Co NPs, while the generated H^(*) is easily adsorbed on Co SAs for HER, which makes the Co SAs-Co NPs/NCFs catalyst exhibit more suitable H adsorption strength and more conducive to the activation and dissociation of H_(2)O molecules. This work not only proposes a novel idea for constructing coupling catalyst with atomic-level precision, but also provides strong reference for the development of high-efficiency HER electrocatalysts for practical application.展开更多
[ Objective] This study aimed to lay theoretical foundation for establishing the database of biological characteristics of raccoon dogs with different coat colors. [Method] Reddish-brown ussuri raccoon dogs, wild ussu...[ Objective] This study aimed to lay theoretical foundation for establishing the database of biological characteristics of raccoon dogs with different coat colors. [Method] Reddish-brown ussuri raccoon dogs, wild ussuri raccoon dogs and Jilln white raccoon dogs were used as experimental materials in this study. Chromosome specimens were prepared by peripheral blood lymphocyte culture, to analyze chromosome number of ussuri raccoon dogs with different coat colors. [ Result] Frequencies of cells with diploid chromosome number of 56 in reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs were 86% and 83% re- spectively, indicating that the chromosome number of reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs was 56. The frequency of cells with diploid chromosome number of 56 in Jilin white raccoom dogs was 70%, which was lower than that of other two varieties, while the frequency of cells with 2n = 57 was high- er than that of other two varieties. [Conclusion] The chromosome number was 56 for reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs, and it was 56 or 57 for Jllin white raccoon dogs, which represented pelymorphism.展开更多
Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the m...Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the most widely used medicinal plant with enormous demand on the market,including Chinese medicine prescriptions,preparations,health care products and even food.Pharmacological studies have shown that these ingredients have broad medicinal value,including anti-cancer and antiinflammatory effects.Although the biosynthetic pathway of glycyrrhizin,a triterpenoid component from G.uralensis,has been fully analyzed,little attention has been paid to the biosynthesis of the flavonoids of this plant.To obtain the enzyme-coding genes responsible for the biosynthesis of LN,analysis and screening were carried out by combining genome and comparative transcriptome database searches of G.uralensis and homologous genes of known flavonoid biosynthesis pathways.The catalytic functions of candidate genes were determined by in vitro or in vivo characterization.This work characterized the complete biosynthetic pathway of LN and achieved the de novo biosynthesis of liquiritin in Saccharomyces cerevisiae using endogenous yeast metabolites as precursors and cofactors for the first time,which provides a possibility for the economical and sustainable production and application of G.uralensis flavonoids through synthetic biology.展开更多
Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable ...Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively.展开更多
The electro-hydrostatic actuator(EHA)used in more electric aircraft(MEA)has been extensively studied due to its advantages of high reliability and high integration.However,this high integration results in a small heat...The electro-hydrostatic actuator(EHA)used in more electric aircraft(MEA)has been extensively studied due to its advantages of high reliability and high integration.However,this high integration results in a small heat dissipation area,leading to high-temperature problems.Generally,to reduce the temperature,a wet cooling method of using the pump leakage oil to cool the motor is adopted,which can also increase the difficulty of accurately predicting the system temperature in the early design stage.To solve this problem,a dynamic coupling thermal model of a wet EHA is proposed in this paper.In particular,the leakage oil of the pump is used as a coupling item between the electrical system and the hydraulic system.Then,an improved T-equivalent block model is proposed to address the uneven distribution of axial oil temperature inside the motor,and the control node method is applied to hydraulic system thermal modeling.Meanwhile,a dynamic coupling thermal model is developed that enables a dynamic evaluation of the wet EHA temperature.Then,experimental prototypes of wet motor and wet EHA are developed,while the temperature response of the wet motor at different rotation speeds and different loads and the temperature response of the wet EHA at no-load condition were verified experimentally at room temperature,respectively.The maximum temperature difference between the experimental and theoretical results of the wet motor as well as the experimental and theoretical results of the wet EHA is less than 8℃.These test results indicate that the dynamic coupling thermal model is valid and demonstrate that the thermal coupling modeling method proposed in this paper can provide a basis for the detailed thermal design of EHA.展开更多
This case study of the Hexi Corridor, Northwestern China, utilizes statistical methods to estimate quantitatively the interaction at a regional level between climate change, ancient social developments, and political ...This case study of the Hexi Corridor, Northwestern China, utilizes statistical methods to estimate quantitatively the interaction at a regional level between climate change, ancient social developments, and political coping strategies over the past 2000 years. The data is sourced from high-resolution reconstructions of climate series(temperature and precipitation), and historical records of cultivated land, war, population, and changes in regional administrative systems. The results show that moisture conditions played a more significant role than temperature in driving land reclamation in the Hexi Corridor. Analysis also showed a negative correlation between war frequency and the area of cultivated land in the Corridor over 20-year time intervals. Population growth was found to have a significant positive correlation with the cultivated land area during the study period. The results indicate that a climate-induced decline in agricultural production and the subsequent fluctuations in population could act as a trigger for social unrest, which is especially true at the mutual decadal time-scales. However, the interaction with administrative reform also suggests that, in the face of social and economic turmoil, a reasonable administrative hierarchy could strengthen the social governance of regional government, and promote social stability and economic development at a regional level. The study substantiates this notion with empirical quantitative evidence.展开更多
In a recent study published in Science,Bridget S.Gosis et al.demonstrate that selective inhibition of the mammalian target of rapamycin complex 1(mTORC1)signaling through deletion of the RagC/D guanosine triphosphatas...In a recent study published in Science,Bridget S.Gosis et al.demonstrate that selective inhibition of the mammalian target of rapamycin complex 1(mTORC1)signaling through deletion of the RagC/D guanosine triphosphatase-activating protein folliculin(FLCN)in mice enhances activation of transcription factor E3(TFE3)in the liver and protects against nonalcoholic fatty liver disease(NAFLD).展开更多
Viruses are important components of the human body.Growing evidence suggests that they are engaged in the physiology and disease status of the host.Even though the vaginal microbiome is involved in human papillomaviru...Viruses are important components of the human body.Growing evidence suggests that they are engaged in the physiology and disease status of the host.Even though the vaginal microbiome is involved in human papillomavirus(HPV)infection and cervical cancer(CC)progression,little is known about the role of the vaginal virome.In this pilot exploratory study,using unbiased viral metagenomics,we aim to investigate the vaginal eukaryotic virome in women with different levels of cervical lesions,and examine their associations with different cervical disease status.An altered eukaryotic virome was observed in women with different levels of lesions and Lactobacillus profiles.Anelloviruses and papillomaviruses are the most commonly detected eukaryotic viruses of the vaginal virome.Higher abundance and richness of anelloviruses and papillomaviruses were associated with lowgrade squamous intraepithelial lesion(LSIL)and CC.Besides,higher anellovirus abundance was also associated with lactobacillus-depleted microbiome profiles and bacterial community state(CST)type IV.Furthermore,increased correlations between Anelloviridae and Papillomaviridae occurred in the women with increased cervical disease severity level from LSIL to CC.These data suggest underlying interactions between different microbes as well as the host physiology.Higher abundance and diversity of both anelloviruses and papillomaviruses shared by LSIL and CC suggest that anellovirus may be used as a potential adjunct biomarker to predict the risk of HPV persistent infection and/or CC.Future studies need to focus on the clinical relevance of anellovirus abundance with cervical disease status,and the evaluation of their potential as a new adjunct biomarker for the prediction and prognoses of CC.展开更多
基金supported by the National Natural Science Foundation of China (No. 21676300)
文摘The bimetallic NiCu/SAPO-11 catalysts were prepared by co-impregnation, sequential impregnation, coprecipitation, and mechanical mixing methods. Powder X-ray diffraction, nitrogen adsorption-desorption,temperature-programmed desorption of ammonia, transmission electron microscopy, temperatureprogrammed reduction of hydrogen, and X-ray photoelectron spectroscopy were used to characterize the physicochemical properties of the catalysts. The catalytic performance of the catalysts was assessed by the hydroisomerization of n-octane. Results indicated that the conversion of n-octane and selectivity to n-octane isomers were related to the preparation methods of the catalysts. The catalysts with Ni-Cu alloy effectively restrained the hydrogenolysis reaction that decreases the selectivity of isomerization. The catalyst prepared by the mechanical mixing of NiO and CuO hardly formed Ni-Cu alloy, showing obvious hydrogenolysis and low selectivity to n-octane isomers. The unbalance between the metal and acid sites resulted in the low conversion of n-octane and selectivity to n-octane isomers. Among all the catalysts,the catalyst prepared by the co-impregnation method exhibited high catalytic activity and selectivity to n-octane isomers.
基金funded by the National Natural Science Foundation of China(31801707)the Key Projects of Science and Technology Research in Henan Province(182102110470)+3 种基金the Plant Protection of Key Discipline Project of Henan province(107020219001/005)the National Key Research and Development Program of China(2016YFD0300203-3)First-Class Postdoctoral Research Grant in Henan Province(001701038)the Science-Technology Foundation for High Level Talent of Henan Institute of Science and Technology(2015028).
文摘Whitefly-transmitted begomoviruses are economically important plant pathogens that cause severe problems in many crop plants,such as tomato,papaya,cotton,and tobacco.Tomato yellow leaf curl virus(TYLCV)is a typical monopartite begomovirus that has been extensively studied,but methods that can efficiently control begomoviruses are still scarce.In this study,we combined artificial microRNA(amiRNA)-mediated silencing technology and clay nanosheetmediated delivery by spraying and developed a method for efficiently preventing TYLCV infection in tomato plants.We designed three amiRNAs that target different regions of TYLCV to silence virus-produced transcripts.Three plant expression vectors expressing pre-amiRNAs were constructed,and recombinant plasmid DNAs(pDNAs)were loaded onto nontoxic and degradable layered double hydroxide(LDH)clay nanosheets.LDH nanosheets containing multiple pDNAs were sprayed onto plant leaves.We found that the designed amiRNAs were significantly accumulated in leaves 7 days after spraying,while the pDNAs were sustainably detected for 35 days after the spray,suggesting that the LDH nanosheets released pDNAs in a sustained manner,protected pDNAs from degradation and efficiently delivered pDNAs into plant cells.Importantly,when the LDH nanosheets coated with pDNAs were sprayed onto plants infected by TYLCV,both the disease severity and TYLCV viral concentration in sprayed plants were significantly decreased during the 35 days,while the levels of H_(2)O_(2) were significantly increased in those plants.Taken together,these results indicate that LDH nanosheets loaded with pDNAs expressing amiRNAs can be a sustainable and promising tool for begomovirus control.
基金supported by the program of National Natural Science Foundation of China(NSFC,32071876,31672193)Open-end Funds of State Key Laboratory of Grassland Agro-ecosystems(SKGAE),Lanzhou University,China.
文摘Salinity and drought stress are major abiotic stresses negatively affecting the growth and productivity of alfalfa(Medicago sativa L.).Exploration of genes exhibiting superior tolerance to salinity and drought stress in alfalfa will help aid target molecular breeding and developing tolerant forages.In this study,we adopted a high-efficient yeast FOX hunting system for the identification of salinity and drought tolerant genes in alfalfa.Based on the Gateway-compatible vector system,a high-quality expression library was constructed,containing 1.3×10^(7) clones with an average size of 1.44 kb.Through heterologous transformation of mixed library plasmid into salt or drought sensitive yeast mutants,monoclonal resistant strains were screened and tolerant genes were captured.Eighteen salinity-tolerance genes were obtained which were involved in several pathways,containing GRAS and zinc finger transcriptional factors,PP2A interaction module,ERVT vesicle transporter and LETM transmembrane protein.Twelve drought tolerance genes were separated,including ERF and SCL transcriptional factors,CIPK and BSK protein kinases,TGL-type ligase,cPGM and cPDL protease.The mRNA transcription levels of these tolerant genes were inducible or suppressible for response to salt or drought stress conditions following quantitative PCR detection,respectively.Furthermore,heterologous transformation of ERVT and CIPK11 can improve the salt and drought stress tolerance in Arabidopsis,which indicates the conservative function of the screening gene in yeast and Arabidopsis.Obtaining these candidate genes can provide new insights for future research with respect to plant salt and drought tolerance.
文摘With the aging in whole world, it has become a great challenge to explore the relationship between the cognitive and behavioral performance of senile dementia and the underlying pathology of the brain. Alzheimer’s disease (AD) is a common age-related and progressive neurodegenerative disease characterized and one of the main causes of senile dementia. The pathogenesis and treatment mechanism of AD are not completely clear. In recent years, it has been found that the Gut microbiota (GM) disorder is related to nervous system diseases. The objective of this review is to summarize the etiology and pathogenyon the role of GM in the development of AD, metabolites of GM and the occurrence of AD, and GM, diabetes and occurrence of AD. Understanding the relationship between GM and AD will help provide possible interventions to improve the structure of GM and prevent AD through different treatments, and it may provide clinicians with a new and more effective way for early diagnosis, prevention and treatment of AD.
基金financial supports from National Natural Science Foundation of China (NSFC)(No.61922033)Foundation for Innovative Research Groups of Hubei Province of China (2018CFA004)Innovation Fund of WNLO
文摘A microfiber with large evanescent field encapsulated in PDMS is proposed and demonstrated for ultrasound sensing.The compact size and large evanescent field of microfiber provide an excellent platform for the interaction between optical signal and ultrasound wave,exhibiting a high sensitivity of 3.5 mV/kPa,which is approximately 10 times higher than the single-mode fiber sensor.Meanwhile,a phase feedback stabilization module is introduced into the coherent demodulation system for long-term stable measurement.In addition,a photoacoustic tomography experiment with the microfiber ultrasound sensor is implemented to verify the excellent performance on imaging,with the depth of 12 mm,the highest lateral resolution of 65μm and axial resolution of 250μm,respectively.The highly sensitive microfiber ultrasound sensor provides a competitive alternative for various applications,such as industrial non-destructive testing,biomedical ultrasound and photoacoustic imaging.
基金supported by the National Natural Science Foundationof China(6130214861101182)
文摘Target micromotion not only plays an important role in target recognition but also leads to esoteric characteristics in synthetic aperture radar (SAR) imaging. This paper finds out an interesting phenomenon, i.e. the angular extent effect, in micro-motion target images formulated by the polar format algorithm. A micromotion target takes on multiple pairs of paired echoes (PEs) around the true point, and each PE extends for an angle which is exactly equal to the angular extent of the synthetic aperture, regardless of the micromotion frequency. The effect is derived and interpreted by using the characteristics of Bessel functions. Then it is demonstrated by simulation experiments of a target with different micromotion frequencies. The revelation and interpretation of the effect is highly beneficial to micromotion-target SAR image understanding as wel as target recognition.
基金partially supported by the National Natural Science Foundation of China(No.21805308)the Taishan Scholar Project of Shandong province,the Key Research and Development Program of Shandong Province(No.2019GSF109075)the Fundamental Research Funds for the Central Universities(No.18CX06065A,No.19CX05001A)。
文摘In this paper,we report a facile strategy to synthesize Co-BDC-NH2 material,which is used as a precursor towards an excellent OER electrocatalyst by thermal annealing in nitrogen.Ultra-small Co/Co Oxnanoparticles were uniformly dispersed on the rhombus N-doped carbon(NC)nanoflakes.Transmission electron microscopic,X-ray diffraction spectrometric,and X-ray photoelectron spectroscopic analyses revealed the coexistence of metallic Co and Co oxides nanoparticles.It was found that Co/CoO_(x)@NC obtained at 500℃ annealing temperature exhibited the highest electrocatalytic OER activity,with 307 and375 m V overpotential to achieve 10 and 100 m A cm^(-2) current densities.Besides,thanks to the in-situ annealing process,Co/CoO_(x)@NC showed excellent catalytic stability with 97.4%current density retention after 24 h electrolysis at 1.66 V vs.RHE electrode potential.Further investigations revealed that the ultrasmall Co/Co Oxnanoparticles distributed on N-doped carbon template contribute significantly towards OER electrocatalysis through enlarging the activity surface areas and enhancing the intrinsic electrochemical activity due to the presence of metallic Co.
基金supported by the Taishan Scholars Program of Shandong Province(tsqn201909065)the Shandong Provincial Natural Science Foundation(ZR2020QB174)+3 种基金the Petro China Innovation Foundation(2019D-5007-0401)the National Natural Science Foundation of China(21776315,22108306)the Fundamental Research Funds for the Central Universities(19CX02008A,19CX05001A)the Postgraduate Innovation Fund of China University of Petroleum(East China)(YCX2020037)。
文摘The development of low-cost, efficient, and high atomic economy electrocatalysts for hydrogen evolution reaction(HER) in the entire p H range for sustainable hydrogen production is of great importance but still challenging. Herein, we synthesize a highly dispersed N-doped carbon frames(NCFs) anchored with Co single atoms(SAs) and Co nanoparticles(NPs) catalyst by a doping-adsorption-pyrolysis strategy for electrocatalytic hydrogen evolution. The Co SAs-Co NPs/NCFs catalyst exhibits an excellent HER activity with small overpotential, low Tafel slope, high turnover frequency as well as remarkable stability. It also exhibits a superior HER performance in the entire p H range. Combining with experimental and theoretical calculation, we find that Co SAs with Co-N_(3) coordination structure and Co NPs have a strong interaction for promoting synergistic HER electrocatalytic process. The H_(2)O molecule is easily activated and dissociated on Co NPs, while the generated H^(*) is easily adsorbed on Co SAs for HER, which makes the Co SAs-Co NPs/NCFs catalyst exhibit more suitable H adsorption strength and more conducive to the activation and dissociation of H_(2)O molecules. This work not only proposes a novel idea for constructing coupling catalyst with atomic-level precision, but also provides strong reference for the development of high-efficiency HER electrocatalysts for practical application.
基金Supported by National Natural Science Foundation of China(31072018)
文摘[ Objective] This study aimed to lay theoretical foundation for establishing the database of biological characteristics of raccoon dogs with different coat colors. [Method] Reddish-brown ussuri raccoon dogs, wild ussuri raccoon dogs and Jilln white raccoon dogs were used as experimental materials in this study. Chromosome specimens were prepared by peripheral blood lymphocyte culture, to analyze chromosome number of ussuri raccoon dogs with different coat colors. [ Result] Frequencies of cells with diploid chromosome number of 56 in reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs were 86% and 83% re- spectively, indicating that the chromosome number of reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs was 56. The frequency of cells with diploid chromosome number of 56 in Jilin white raccoom dogs was 70%, which was lower than that of other two varieties, while the frequency of cells with 2n = 57 was high- er than that of other two varieties. [Conclusion] The chromosome number was 56 for reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs, and it was 56 or 57 for Jllin white raccoon dogs, which represented pelymorphism.
基金supported by the National Natural Science Foundation of China(No.81773838)the National Program for Special Support of Eminent Professionalsthe Key Project at central government level(No.2060302,China).
文摘Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the most widely used medicinal plant with enormous demand on the market,including Chinese medicine prescriptions,preparations,health care products and even food.Pharmacological studies have shown that these ingredients have broad medicinal value,including anti-cancer and antiinflammatory effects.Although the biosynthetic pathway of glycyrrhizin,a triterpenoid component from G.uralensis,has been fully analyzed,little attention has been paid to the biosynthesis of the flavonoids of this plant.To obtain the enzyme-coding genes responsible for the biosynthesis of LN,analysis and screening were carried out by combining genome and comparative transcriptome database searches of G.uralensis and homologous genes of known flavonoid biosynthesis pathways.The catalytic functions of candidate genes were determined by in vitro or in vivo characterization.This work characterized the complete biosynthetic pathway of LN and achieved the de novo biosynthesis of liquiritin in Saccharomyces cerevisiae using endogenous yeast metabolites as precursors and cofactors for the first time,which provides a possibility for the economical and sustainable production and application of G.uralensis flavonoids through synthetic biology.
基金supported by the National Natural Science Foundation of China(No.21676300)the Shandong Provincial Natural Science Foundation(No.ZR2018MB035)+3 种基金the Fundamental Research Funds for the Central Universities(Nos.19CX02008A and 16CX06007A)PetroChina Innovation Foundation(No.2019D-5007-0401)Taishan Scholars Program of Shandong Province(No.tsqn201909065)Tsinghua University Initiative Scientific Research Program.
文摘Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively.
基金We thank Prof. Mingbo Wu (State Key Laboratory of Heavy Oil Processing, China University of Petroleum) for his help in experiments. This work was finandally supported by the Key Joint Foundation of PetroChina, the National Natural Science Foundation of China (Nos. 51271215, U1362202, and 21106185) and the PetroChina Key Programs on Oil Refinery Catalysts (No. 2010E-1908 and 2010E-1903).
基金co-supported by the National Natural Science Foundation of China (No. 51890882)National Key Research and Development Program of China (No. 2018YFB2000702)
文摘The electro-hydrostatic actuator(EHA)used in more electric aircraft(MEA)has been extensively studied due to its advantages of high reliability and high integration.However,this high integration results in a small heat dissipation area,leading to high-temperature problems.Generally,to reduce the temperature,a wet cooling method of using the pump leakage oil to cool the motor is adopted,which can also increase the difficulty of accurately predicting the system temperature in the early design stage.To solve this problem,a dynamic coupling thermal model of a wet EHA is proposed in this paper.In particular,the leakage oil of the pump is used as a coupling item between the electrical system and the hydraulic system.Then,an improved T-equivalent block model is proposed to address the uneven distribution of axial oil temperature inside the motor,and the control node method is applied to hydraulic system thermal modeling.Meanwhile,a dynamic coupling thermal model is developed that enables a dynamic evaluation of the wet EHA temperature.Then,experimental prototypes of wet motor and wet EHA are developed,while the temperature response of the wet motor at different rotation speeds and different loads and the temperature response of the wet EHA at no-load condition were verified experimentally at room temperature,respectively.The maximum temperature difference between the experimental and theoretical results of the wet motor as well as the experimental and theoretical results of the wet EHA is less than 8℃.These test results indicate that the dynamic coupling thermal model is valid and demonstrate that the thermal coupling modeling method proposed in this paper can provide a basis for the detailed thermal design of EHA.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA19040101)the Key Research Program of the Chinese Academy of Sciences (Grant No. ZDRW-ZS-2016-6 and KGFZD-135-17-009-1)
文摘This case study of the Hexi Corridor, Northwestern China, utilizes statistical methods to estimate quantitatively the interaction at a regional level between climate change, ancient social developments, and political coping strategies over the past 2000 years. The data is sourced from high-resolution reconstructions of climate series(temperature and precipitation), and historical records of cultivated land, war, population, and changes in regional administrative systems. The results show that moisture conditions played a more significant role than temperature in driving land reclamation in the Hexi Corridor. Analysis also showed a negative correlation between war frequency and the area of cultivated land in the Corridor over 20-year time intervals. Population growth was found to have a significant positive correlation with the cultivated land area during the study period. The results indicate that a climate-induced decline in agricultural production and the subsequent fluctuations in population could act as a trigger for social unrest, which is especially true at the mutual decadal time-scales. However, the interaction with administrative reform also suggests that, in the face of social and economic turmoil, a reasonable administrative hierarchy could strengthen the social governance of regional government, and promote social stability and economic development at a regional level. The study substantiates this notion with empirical quantitative evidence.
基金State Key Project on Infectious Diseases of China(2018ZX10723204-002-002)National Natural Science Foundation of China(81672777,81671314,82002522,82172896)+1 种基金Shanghai Rising-Star Program(17QA1405700)Shanghai Top Young Talents Program,Research Program of Changzheng Hospital(2019CZJS102).
文摘In a recent study published in Science,Bridget S.Gosis et al.demonstrate that selective inhibition of the mammalian target of rapamycin complex 1(mTORC1)signaling through deletion of the RagC/D guanosine triphosphatase-activating protein folliculin(FLCN)in mice enhances activation of transcription factor E3(TFE3)in the liver and protects against nonalcoholic fatty liver disease(NAFLD).
基金supported by the startup funding from Shanghai Public Health Clinical Center(to CZ).
文摘Viruses are important components of the human body.Growing evidence suggests that they are engaged in the physiology and disease status of the host.Even though the vaginal microbiome is involved in human papillomavirus(HPV)infection and cervical cancer(CC)progression,little is known about the role of the vaginal virome.In this pilot exploratory study,using unbiased viral metagenomics,we aim to investigate the vaginal eukaryotic virome in women with different levels of cervical lesions,and examine their associations with different cervical disease status.An altered eukaryotic virome was observed in women with different levels of lesions and Lactobacillus profiles.Anelloviruses and papillomaviruses are the most commonly detected eukaryotic viruses of the vaginal virome.Higher abundance and richness of anelloviruses and papillomaviruses were associated with lowgrade squamous intraepithelial lesion(LSIL)and CC.Besides,higher anellovirus abundance was also associated with lactobacillus-depleted microbiome profiles and bacterial community state(CST)type IV.Furthermore,increased correlations between Anelloviridae and Papillomaviridae occurred in the women with increased cervical disease severity level from LSIL to CC.These data suggest underlying interactions between different microbes as well as the host physiology.Higher abundance and diversity of both anelloviruses and papillomaviruses shared by LSIL and CC suggest that anellovirus may be used as a potential adjunct biomarker to predict the risk of HPV persistent infection and/or CC.Future studies need to focus on the clinical relevance of anellovirus abundance with cervical disease status,and the evaluation of their potential as a new adjunct biomarker for the prediction and prognoses of CC.