On the road: Clinical trials with stem cell extended to non-hematologic disease

Increasing evidence in scientific journals declares that stem cell can be used in human medicine for therapeutic purposes. We reviewed the lated literature on clinical trials conducted with stem cells. The main information was offered by http://www.ClinicalTrials.gov. These clinical trials cover almost all human diseases, from hematologic diseases to non-hematologic diseases including Interventional trials and observational trials. In conclusion, at present, the clinical trials with stem cells have been extending to almost all human diseases. Optimal medicinal effect reported in some non-hematologic diseases is pushing the advance of stem cells

Reduction in COVID-19 related resource loss and decline in prevalence of probable depression in Chinese adults:an application of the Conservation of Resource Theory

Background The levels of resource losses due to coronavirus disease 2019(COVID-19)and mental distress may change during the pandemic period.Based on the Conservation of Resource(COR)Theory,this study investigated such changes and the mediation between survey time(Round 2 versus Round 1)and depression via resource losses.Methods Two serial random population-based telephone surveys interviewed 209 and 458 Hong Kong Chinese adults in April 2020 and May 2021,respectively.Probable depression was defined as 9-item Patient Health Questionnaire(PHQ-9)score≥10.The validated Conservation of Resources Scale for COVID-19(CORS-COVID-19)scale was used to assess resource losses due to COVID-19.Multivariable logistic regression analysis,hierarchical logistic regression analysis,and structural equation modeling(SEM)was conducted to test the association,interaction,and mediation hypotheses,respectively.Results The prevalence of probable depression declined from 8.6%to 1.0%over time,together with reductions in losses of financial resource(Cohen’s d=0.88),future control(Cohen’s d=0.39),social resource(Cohen’s d=0.60),and family resource(Cohen’s d=0.36)due to COVID-19.All the overall scale/subscales of the CORS-COVID-19 were positively and associated with probable depression[adjusted odds ratio(aOR)ranged from 2.72 to 42.30].In SEM,the survey time was negatively associated with the latent variable of resource loss(β=−0.46),which in turn was positively associated with probable depression(β=0.73).In addition,the direct effect of survey time on probable depression was statistically non-significant(β=−0.08),indicating a full mediation effect of resource losses.Conclusions The lessening of the resource losses might have fully accounted for the significant decline in probable depression from Month 3 to 15 since the first COVID-19 outbreak in Hong Kong,China.The level of depression might have increased during the first phase of the pandemic,but might decline in the later phases if resources losses could be lessened.All stakeholders should hence work together to minimize individuals’COVID-19-related resource losses to prevent depression in the general population,as COVID-19 might be lasting.

Facile synthesis of Ni-doped SnO_(2) nanorods and their high gas sensitivity to isopropanol

In this work,pure SnO_(2) and Ni-doped SnO_(2) nanorods were synthesized through a one-step template-free hydrothermal method and then used to detect isopropanol.Sensors fabricated with the Ni-doped SnO_(2) nanocomposites showed the best gas sensing performance when the Ni doping amount was 1.5 mol.%.The response reached 250 at 225℃,which was approximately 8.3 times higher than that of the pure SnO_(2) nanorods.The limit of detection for isopropanol was as low as 10 ppb at the optimum working temperature.In addition,it also displayed good selectivity and excellent reproducibility.It is believed that the enhanced isopropanol sensing behavior benefit from the increased oxygen defects and larger specific surface area by Ni doping.