Obesity is crucially involved in many metabolic diseases,such as type 2 diabetes,cardiovascular disease and cancer.Regulating the number or size of adipocytes has been suggested to be a potential treatment for obesity...Obesity is crucially involved in many metabolic diseases,such as type 2 diabetes,cardiovascular disease and cancer.Regulating the number or size of adipocytes has been suggested to be a potential treatment for obesity.In this study,we investigated the effect of pyrocincholic acid 3β-O-β-D-quinovopyranosyl-28-O-β-D-glucopyranoside(PAQG),a 27-nor-oleanolic acid saponin extracted from Metadina trichotoma,on adipogenesis and lipid metabolism in 3T3-L1 adipocytes.The 3T3-L1 pre-adipocytes were incubated with vehicle or PAQG for 6 days in differentiation process.PAQG significantly reduced the adipogenesis,adiponectin secretion and the expression level of key transcription factors related to adipogenesis,such as PPARc,C/EBPb,C/EBPa,and FABP4.Moreover,PAQG increased the levels of FFA and glycerol in medium and reduced TG level in mature adipocytes.Interestingly,PAQG not only promoted the activation of AMPK and genes involved in fatty oxidation including PDK4 and CPT1a,but also inhibited those genes involved in fatty acid biosynthesis,such as SREBP1c,FAS,ACCa and SCD1.In conclusion,PAQG inhibits the differentiation and regulates lipid metabolism of 3T3-L1 cells via AMPK pathway,suggesting that PAQG may be a novel and promising natural product for the treatment of obesity and hyperlipidemia.展开更多
Taking the Zhejiang Academy of Agricultural Sciences as an example,the modes and approaches of combing industry-universities-research institutions to promote rural revitalization by agricultural scientific research un...Taking the Zhejiang Academy of Agricultural Sciences as an example,the modes and approaches of combing industry-universities-research institutions to promote rural revitalization by agricultural scientific research units are discussed.The main approaches are as follows:focusing on practical technical training to promote the transformation of scientific and technological achievements,transferring scientific and technological achievements to promote the deep integration of basic research,applied research and achievement transformation,and using the agronomist college as a carrier to promote the integrated development of industry-universities-research institutions and promote rural revitalization through systematic personnel training.展开更多
The modes and approaches of promoting the implementation of strategy for rural revitalization based on agricultural science and technology commissioner system were studied by taking Zhejiang Academy of Agricultural Sc...The modes and approaches of promoting the implementation of strategy for rural revitalization based on agricultural science and technology commissioner system were studied by taking Zhejiang Academy of Agricultural Sciences as an example.The relevant modes and approaches were summarized,such as giving full play to the expertise of science and technology commissioners to promote the prosperity of rural industries,promoting ecological livable construction based on modern agricultural science and technology,promoting rural civilization based on agricultural science and technology,and promoting the construction of rural good governance based on advanced productivity.Besides,agricultural science and technology commissioners use the three elements of"people,technology,and money"to promote the enhancement of agricultural efficiency,farmers’income,and the prosperity of life and then the coordinated development of rural revitalization.展开更多
Taking rice production in Zhejiang Province as an example,the ideas and key technologies for adjusting the development of rice industry from the perspective of the entire industrial chain are discussed.It is believed ...Taking rice production in Zhejiang Province as an example,the ideas and key technologies for adjusting the development of rice industry from the perspective of the entire industrial chain are discussed.It is believed that the development of high-quality rice should be regarded as an important guide for industrial transformation and upgrading to promote the healthy development of high-quality rice industry.The key to the development of highquality rice is the technical promotion of the entire industrial chain of rice production.It is necessary to actively promote the breeding of rice varieties with good taste quality and the improvement,demonstration and promotion of green cultivation techniques,promote the improvement,demonstration and promotion of rice storage and preservation technology and rice deep processing technology,promote the demonstration and promotion of the integrated production and marketing model of variety and brand,and promote the development of beautiful rice fields and colored special rice,so as to enhance the efficiency and competitiveness of rice industry in Zhejiang Province and help rural revitalization.展开更多
文摘Obesity is crucially involved in many metabolic diseases,such as type 2 diabetes,cardiovascular disease and cancer.Regulating the number or size of adipocytes has been suggested to be a potential treatment for obesity.In this study,we investigated the effect of pyrocincholic acid 3β-O-β-D-quinovopyranosyl-28-O-β-D-glucopyranoside(PAQG),a 27-nor-oleanolic acid saponin extracted from Metadina trichotoma,on adipogenesis and lipid metabolism in 3T3-L1 adipocytes.The 3T3-L1 pre-adipocytes were incubated with vehicle or PAQG for 6 days in differentiation process.PAQG significantly reduced the adipogenesis,adiponectin secretion and the expression level of key transcription factors related to adipogenesis,such as PPARc,C/EBPb,C/EBPa,and FABP4.Moreover,PAQG increased the levels of FFA and glycerol in medium and reduced TG level in mature adipocytes.Interestingly,PAQG not only promoted the activation of AMPK and genes involved in fatty oxidation including PDK4 and CPT1a,but also inhibited those genes involved in fatty acid biosynthesis,such as SREBP1c,FAS,ACCa and SCD1.In conclusion,PAQG inhibits the differentiation and regulates lipid metabolism of 3T3-L1 cells via AMPK pathway,suggesting that PAQG may be a novel and promising natural product for the treatment of obesity and hyperlipidemia.
基金Science and Technology Planning Project of Zhejiang Province(2018C02057,2018C02055)National Rice Industry Technology System(CARS-01-48).
文摘Taking the Zhejiang Academy of Agricultural Sciences as an example,the modes and approaches of combing industry-universities-research institutions to promote rural revitalization by agricultural scientific research units are discussed.The main approaches are as follows:focusing on practical technical training to promote the transformation of scientific and technological achievements,transferring scientific and technological achievements to promote the deep integration of basic research,applied research and achievement transformation,and using the agronomist college as a carrier to promote the integrated development of industry-universities-research institutions and promote rural revitalization through systematic personnel training.
基金Supported by Science and Technology Planning Project of Zhejiang Province(2018C02057)National Rice Industry Technology System(CARS-01-48)Major Scientific and Technological Project for the Breeding of New Agricultural(Grain)Varieties in Zhejiang Province(2016C02050-5).
文摘The modes and approaches of promoting the implementation of strategy for rural revitalization based on agricultural science and technology commissioner system were studied by taking Zhejiang Academy of Agricultural Sciences as an example.The relevant modes and approaches were summarized,such as giving full play to the expertise of science and technology commissioners to promote the prosperity of rural industries,promoting ecological livable construction based on modern agricultural science and technology,promoting rural civilization based on agricultural science and technology,and promoting the construction of rural good governance based on advanced productivity.Besides,agricultural science and technology commissioners use the three elements of"people,technology,and money"to promote the enhancement of agricultural efficiency,farmers’income,and the prosperity of life and then the coordinated development of rural revitalization.
基金Supported by the Science and Technology Planning Project of Zhejiang Province,China(2018C02055)。
文摘Taking rice production in Zhejiang Province as an example,the ideas and key technologies for adjusting the development of rice industry from the perspective of the entire industrial chain are discussed.It is believed that the development of high-quality rice should be regarded as an important guide for industrial transformation and upgrading to promote the healthy development of high-quality rice industry.The key to the development of highquality rice is the technical promotion of the entire industrial chain of rice production.It is necessary to actively promote the breeding of rice varieties with good taste quality and the improvement,demonstration and promotion of green cultivation techniques,promote the improvement,demonstration and promotion of rice storage and preservation technology and rice deep processing technology,promote the demonstration and promotion of the integrated production and marketing model of variety and brand,and promote the development of beautiful rice fields and colored special rice,so as to enhance the efficiency and competitiveness of rice industry in Zhejiang Province and help rural revitalization.
