In the phase diagram of the nickel-based superconductor Ba_(1-x)Sr_(x)Ni_(2)As_(2),T_(C) has been found to be enhanced sixfold near the quantum critical point(QCP) x=0.71 compared with the parent compound.However,the ...In the phase diagram of the nickel-based superconductor Ba_(1-x)Sr_(x)Ni_(2)As_(2),T_(C) has been found to be enhanced sixfold near the quantum critical point(QCP) x=0.71 compared with the parent compound.However,the mechanism is still under debate.Here,we report a detailed investigation of the superconducting properties near the QCP(x≈0.7) by utilizing scanning tunneling microscopy and spectroscopy.The temperature-dependent superconducting gap and magnetic vortex state were obtained and analyzed in the framework of the Bardeen-Cooper-Schrieffer model.The ideal isotropic s-wave superconducting gap excludes the long-speculated nematic fluctuations while preferring strong electron-phonon coupling as the mechanism for T_(C) enhancement near the QCP.The lower than expected gap ratio of Δ/(k_(B) T_(C)) is rooted in the fact that Ba_(1-x)Sr_(x)Ni_(2)As_(2) falls into the dirty limit with a serious pair breaking effect similar to the parent compound.展开更多
Spin-valley polarization and bandgap regulation are critical in the developing of quantum devices.Here,by employing the density functional theory,we investigate the effects of stacking form,thickness and magnetic mome...Spin-valley polarization and bandgap regulation are critical in the developing of quantum devices.Here,by employing the density functional theory,we investigate the effects of stacking form,thickness and magnetic moment in the electronic structures of WSe_(2)–MoS_(2)heterostructures.Calculations show that spin-valley polarization maintains in all situations.Increasing thickness of 2H-MoS_(2)not only tunes the bandgap but also changes the degeneracy of the conduction band minimums(CBM)at K/K_(1) points.Gradual increase of micro magnetic moment tunes the bandgap and raises the valence band maximums(VBM)atΓpoint.In addition,the regulation of band gap by the thickness of 2H-MoS_(2)and introduced magnetic moment depends on the stacking type.Results suggest that WSe_(2)–MoS_(2)heterostructure supports an ideal platform for valleytronics applications.Our methods also give new ways of optical absorption regulation in spin-valley devices.展开更多
To reveal the intrinsic properties of the basic superconducting units,i.e.,the single layered FeSe/FeAs in iron-based superconductors or CuO_(2) planes in cuprate superconductors,is a necessary prerequisite for unders...To reveal the intrinsic properties of the basic superconducting units,i.e.,the single layered FeSe/FeAs in iron-based superconductors or CuO_(2) planes in cuprate superconductors,is a necessary prerequisite for understanding the mechanism of high-Tc superconductivity.Up to now,an isolated FeAs layer has rarely been studied due to the difficulty in materials synthesis.Here,we report a scanning tunneling microscopy/spectroscopy(STM/STS)study on the iron-based superconductor KCa_(2)Fe_(4)As_(4)F_(2).In situ cleavage produced a single FeAs layer covered by a reconstructed K surface,which is isolated from the bulk by the underlying CaF layer and shows multi-band superconductivity with a much lower T_(c) than its bulk counterpart.In the exposed As-terminated regions with coverage of scattered K atoms,a pseudogap was observed,leading to an inhomogeneous superconductivity without long-range phase coherence in real space,which is remarkably similar to the high-T_(c) cuprate superconductors.These results provide a new perspective to understanding the origin of superconductivity in iron-based superconductors.展开更多
We previously reported that SM934, a water-soluble artemisinin derivative, was a viable treatment in murine lupus models. In the current study, we further investigated the therapeutic effects of a modified dosage regi...We previously reported that SM934, a water-soluble artemisinin derivative, was a viable treatment in murine lupus models. In the current study, we further investigated the therapeutic effects of a modified dosage regimen of SM934 on lupus-prone MRIJIpr mice and explored its effects on B cell responses, a central pathogenic event in systemic lupus erythematosus （SLE）. When orally administered twice-daily, SM934 significantly prolonged the life-span of MRL/Ipr mice, ameliorated the lymphadenopathy symptoms and decreased the levels of serum anti-nuclear antibodies （ANAs） and of the pathogenic cytokines IL-6, IL-10 and I L-21. Furthermore, SM934 treatment restored the B-cell compartment in the spleen of MRL/Ipr mice by increasing quiescent B cell numbers, maintaining germinal center B-cell numbers, decreasing activated B cell numbers and reducing plasma cell （PC） numbers. Ex vivo, SM934 suppressed the Toll-like receptor （TLR）-triggered activation and proliferation of B cells, as well as antibody secretion. Moreover, the present study demonstrated that SM934 interfered with the B-cell intrinsic pathway by downregulating TLR7/9 mRNA expression, MyD88 protein expression and NF-KB phosphorylation. In human peripheral blood mononuclear cells （PBMCs）, consistent with the results in MRIJIprmice, SM934 inhibited TLR-associated B-cell activation and PC differentiation. In conclusion, a twice daily dosing regimen of SM934 had therapeutic effects on lupus-prone MRL/Iprmice by suppressing B cell activation and plasma cell formation.展开更多
Artemisinin drugs are a family of sesquiterpene trioxane lactone agents originally derived from Artemisia annua L. Due to the big victory in the antimalarial battle,the 2015 Nobel Prize goes to the discoverer of artem...Artemisinin drugs are a family of sesquiterpene trioxane lactone agents originally derived from Artemisia annua L. Due to the big victory in the antimalarial battle,the 2015 Nobel Prize goes to the discoverer of artemisininbased therapy for malaria. Beyond antimalaria, artemisinin and its derivatives are also being investigated in diseases like schistosomiasis, viral infection, cancers and inflammation. Over the past decades, the anti-inflammatory and immunomodulatory effects of artemisinin drugs have been comprehensively studied. In this article, we will briefly describe the development of artemisinin drugs, especially novel artemisinin derivatives, in the treatment of autoimmune diseases.展开更多
Recent convergence of information communications technology and computing is creating new demands and opportunities for ubiquitous computing via wireless and mobile equipments. The demanding networking environment of ...Recent convergence of information communications technology and computing is creating new demands and opportunities for ubiquitous computing via wireless and mobile equipments. The demanding networking environment of wireless communications and the fast-growing number of mobile users impose several challenges in terms of channel estimation, network protocol design, resource management, systematic design, application development, and security. The objective of this special issue is to gather recent advances addressing networks, systems, algorithms, and applications that support the symbiosis of mobile computers and wireless networks.展开更多
基金Project supported by the National Key R&D Program of China (Grant Nos. 2022YFA1403203, 2022YFA1403400, and 2021YFA1400400)the Innovation Program for Quantum Science and Technology (Grant No. 2021ZD0302802)+2 种基金the National Natural Science Foundation of China (Grant Nos. 12074002, 12104004, 12204008, and 12374133)the Chinese Academy of Sciences (Grant Nos. XDB33000000 and GJTD-2020-01)the Major Basic Program of Natural Science Foundation of Shandong Province (Grant No. ZR2021ZD01)。
文摘In the phase diagram of the nickel-based superconductor Ba_(1-x)Sr_(x)Ni_(2)As_(2),T_(C) has been found to be enhanced sixfold near the quantum critical point(QCP) x=0.71 compared with the parent compound.However,the mechanism is still under debate.Here,we report a detailed investigation of the superconducting properties near the QCP(x≈0.7) by utilizing scanning tunneling microscopy and spectroscopy.The temperature-dependent superconducting gap and magnetic vortex state were obtained and analyzed in the framework of the Bardeen-Cooper-Schrieffer model.The ideal isotropic s-wave superconducting gap excludes the long-speculated nematic fluctuations while preferring strong electron-phonon coupling as the mechanism for T_(C) enhancement near the QCP.The lower than expected gap ratio of Δ/(k_(B) T_(C)) is rooted in the fact that Ba_(1-x)Sr_(x)Ni_(2)As_(2) falls into the dirty limit with a serious pair breaking effect similar to the parent compound.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61975224 and 12104004)the University Synergy Innovation Program of Anhui Province(Grant No.GXXT-2020-050)+2 种基金the Fund of Anhui Provincial Natural Science Foundation(Grant No.2008085MF206)New magnetoelectric materials and devices,the Recruitment Program for Leading Talent Team of Anhui Province 2020,State Key Laboratory of Luminescence and Applications(Grant No.SKLA-2021-03)the Open Fund of Infrared and Low-Temperature Plasma Key Laboratory of Anhui Province(Grant No.IRKL2022KF03)。
文摘Spin-valley polarization and bandgap regulation are critical in the developing of quantum devices.Here,by employing the density functional theory,we investigate the effects of stacking form,thickness and magnetic moment in the electronic structures of WSe_(2)–MoS_(2)heterostructures.Calculations show that spin-valley polarization maintains in all situations.Increasing thickness of 2H-MoS_(2)not only tunes the bandgap but also changes the degeneracy of the conduction band minimums(CBM)at K/K_(1) points.Gradual increase of micro magnetic moment tunes the bandgap and raises the valence band maximums(VBM)atΓpoint.In addition,the regulation of band gap by the thickness of 2H-MoS_(2)and introduced magnetic moment depends on the stacking type.Results suggest that WSe_(2)–MoS_(2)heterostructure supports an ideal platform for valleytronics applications.Our methods also give new ways of optical absorption regulation in spin-valley devices.
基金supported by the National Key Research and Development Program of China(Grant Nos.2018YFA0305602,2022YFA1403203,and 2017YFA0303201)the National Natural Science Foundation of China(Grant Nos.12074002,92265104,12022413,11674331,and 12104004)+2 种基金the“Strategic Priority Research Program(B)”of the Chinese Academy of Sciences(Grant No.XDB33030100)the Major Basic Program of Natural Science Foundation of Shandong Province(Grant No.ZR2021ZD01)supported by the High Magnetic Field Laboratory of Anhui Province,China。
文摘To reveal the intrinsic properties of the basic superconducting units,i.e.,the single layered FeSe/FeAs in iron-based superconductors or CuO_(2) planes in cuprate superconductors,is a necessary prerequisite for understanding the mechanism of high-Tc superconductivity.Up to now,an isolated FeAs layer has rarely been studied due to the difficulty in materials synthesis.Here,we report a scanning tunneling microscopy/spectroscopy(STM/STS)study on the iron-based superconductor KCa_(2)Fe_(4)As_(4)F_(2).In situ cleavage produced a single FeAs layer covered by a reconstructed K surface,which is isolated from the bulk by the underlying CaF layer and shows multi-band superconductivity with a much lower T_(c) than its bulk counterpart.In the exposed As-terminated regions with coverage of scattered K atoms,a pseudogap was observed,leading to an inhomogeneous superconductivity without long-range phase coherence in real space,which is remarkably similar to the high-T_(c) cuprate superconductors.These results provide a new perspective to understanding the origin of superconductivity in iron-based superconductors.
文摘We previously reported that SM934, a water-soluble artemisinin derivative, was a viable treatment in murine lupus models. In the current study, we further investigated the therapeutic effects of a modified dosage regimen of SM934 on lupus-prone MRIJIpr mice and explored its effects on B cell responses, a central pathogenic event in systemic lupus erythematosus （SLE）. When orally administered twice-daily, SM934 significantly prolonged the life-span of MRL/Ipr mice, ameliorated the lymphadenopathy symptoms and decreased the levels of serum anti-nuclear antibodies （ANAs） and of the pathogenic cytokines IL-6, IL-10 and I L-21. Furthermore, SM934 treatment restored the B-cell compartment in the spleen of MRL/Ipr mice by increasing quiescent B cell numbers, maintaining germinal center B-cell numbers, decreasing activated B cell numbers and reducing plasma cell （PC） numbers. Ex vivo, SM934 suppressed the Toll-like receptor （TLR）-triggered activation and proliferation of B cells, as well as antibody secretion. Moreover, the present study demonstrated that SM934 interfered with the B-cell intrinsic pathway by downregulating TLR7/9 mRNA expression, MyD88 protein expression and NF-KB phosphorylation. In human peripheral blood mononuclear cells （PBMCs）, consistent with the results in MRIJIprmice, SM934 inhibited TLR-associated B-cell activation and PC differentiation. In conclusion, a twice daily dosing regimen of SM934 had therapeutic effects on lupus-prone MRL/Iprmice by suppressing B cell activation and plasma cell formation.
基金supported by the National Natural Science Foundation of China(812735248127352581322049)the National Basic Research Program of China(2014CB541906)
文摘Artemisinin drugs are a family of sesquiterpene trioxane lactone agents originally derived from Artemisia annua L. Due to the big victory in the antimalarial battle,the 2015 Nobel Prize goes to the discoverer of artemisininbased therapy for malaria. Beyond antimalaria, artemisinin and its derivatives are also being investigated in diseases like schistosomiasis, viral infection, cancers and inflammation. Over the past decades, the anti-inflammatory and immunomodulatory effects of artemisinin drugs have been comprehensively studied. In this article, we will briefly describe the development of artemisinin drugs, especially novel artemisinin derivatives, in the treatment of autoimmune diseases.
基金supported by the National Key Research and Development Program of China(2018YFA0704200,2017YFA0302904,2019YFA0308500,and 2018YFA0305602)the National Natural Science Foundation of China(12074414,12074002,52072401,11804379,and 11774402)+1 种基金the Recruitment Program for Leading Talent Team of Anhui Province(2019-16)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB25000000)。
文摘Recent convergence of information communications technology and computing is creating new demands and opportunities for ubiquitous computing via wireless and mobile equipments. The demanding networking environment of wireless communications and the fast-growing number of mobile users impose several challenges in terms of channel estimation, network protocol design, resource management, systematic design, application development, and security. The objective of this special issue is to gather recent advances addressing networks, systems, algorithms, and applications that support the symbiosis of mobile computers and wireless networks.
