In the current situation of economic globalization and communalization with a shared future for mankind,it is crucial to cultivate outstanding composite talents who possess morality,literacy,patriotism,business knowle...In the current situation of economic globalization and communalization with a shared future for mankind,it is crucial to cultivate outstanding composite talents who possess morality,literacy,patriotism,business knowledge,good cross-cultural communication skills,and teamwork spirit.This requires the Business English major to increase the reform of course ideology.This article will propose several innovative paths for the ideological and political education of Business English Reading courses based on the necessity of conducting ideological and political education in Business English majors and working together with colleagues to study.展开更多
This paper is concerned with the asymptotic behavior of solutions to the initial boundary problem of the two-dimensional density-dependent Boussinesq equations.It is shown that the solutions of the Boussinesq equation...This paper is concerned with the asymptotic behavior of solutions to the initial boundary problem of the two-dimensional density-dependent Boussinesq equations.It is shown that the solutions of the Boussinesq equations converge to those of zero thermal diffusivity Boussinesq equations as the thermal diffusivity tends to zero,and the convergence rate is established.In addition,we prove that the boundary-layer thickness is of the valueδ(k)=k^(α)with anyα∈(0,1/4)for a small diffusivity coefficient k>0,and we also find a function to describe the properties of the boundary layer.展开更多
Acute promyelocytic leukemia(APL)is a special leukemia accounting for above 10%of adult acute myeloid leukemia.The t(15;17)(q22;q21)is a specific chromosome reciprocal translocation of APL,resulting in the generation ...Acute promyelocytic leukemia(APL)is a special leukemia accounting for above 10%of adult acute myeloid leukemia.The t(15;17)(q22;q21)is a specific chromosome reciprocal translocation of APL,resulting in the generation of a fusion gene between a retinoic acid receptor alpha(RARα)and promyelocytic leukemia(PML)at the molecular level.Many research demonstrate that PML/RARa fusion gene can be regarded as展开更多
Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glu...Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the genome-wide data of bin ding sites of the core pluripotency factors (SOX2, OCT4, NANOG, denoted SON), chromosomal interaction and histone modification in hESCs, we identified a potential enhancer of the GLUT1 gene in hESCs, de noted GLUT1 enhancer (GE) element GE interacts with the promoter of GLUT1, and the deletion of GE significantly reduces the expression of GLUT1, glucose uptake and glycolysis of hESCs, confirming that GE is an enhancer of GLUT1 in hESCs. In addition, the mutation of SON binding motifs within GE reduced the expression of GLUT1 as well as the interaction between GE and GLUT1 promoter, indicating that the binding of SON to GE is important for its activity. Therefore, SON promotes glucose uptake and glycolysis in hESCs by inducing GLUT1 expression through directly activating the enhancer of GLUT1.展开更多
Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by monocropping.However,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been elu...Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by monocropping.However,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been elucidated.Therefore,we investigated bacterial community structures in response to monocropped alfalfa along the chronosequence.Continuous cropping remarkably reduced bacterial alpha diversity and altered community structures,and soil pH,total P and available P were strongly associated with the changes of bacterial diversity and community structures.Intriguingly,10 years of monocropped alfalfa might be a demarcation point separating soil bacterial community structures into two obvious groups that containing soil samples collected in less and more than 10 years.The relative abundances of copiotrophic bacteria of Actinobacteria and Gammaproteobacteria significantly increased with the extension of continuous cropping years,while the oligotrophic bacteria of Armatimonadetes,Chloroflexi,Firmicutes and Gemmatimonadetes showed the opposite changing patterns.Among those altered phyla,Actinobacteria,Chloroflexi,Alphaproteobacteria and Acidobacteria were the most important bacteria which contributed 50.86%of the community variations. Additionally, the relative abundances of nitrogen fixation bacteria ofBradyrhizobium and Mesorhizobium obviously increased with continuous cropping years, while theabundances of Arthrobacter, Bacillus, Burkholderiaceae and Microbacterium with potential functionsof solubilizing phosphorus and potassium remarkably decreased after long-term continuouscropping. Furthermore, bacterial cooccurrence patterns were significantly influenced by continuouscropping years, with long-term monocropped alfalfa simplifying the complexity of the cooccurrencenetworks. These findings enhanced our understandings and provided references for forecasting howsoil bacterial communities responds to monocropped alfalfa.展开更多
基金Heilongjiang Provincial Education Science“14th Five-Year Plan”2022 Key Project“Research on the Recitation of Chinese Classics in College English Majors Under the New Liberal Arts”(Project number:GJB1422589)。
文摘In the current situation of economic globalization and communalization with a shared future for mankind,it is crucial to cultivate outstanding composite talents who possess morality,literacy,patriotism,business knowledge,good cross-cultural communication skills,and teamwork spirit.This requires the Business English major to increase the reform of course ideology.This article will propose several innovative paths for the ideological and political education of Business English Reading courses based on the necessity of conducting ideological and political education in Business English majors and working together with colleagues to study.
基金the National Natural Science Foundation of China(12061037,11971209)the Natural Science Foundation of Jiangxi Province(20212BAB201016)National Natural Science Foundation of China(11861038)。
文摘This paper is concerned with the asymptotic behavior of solutions to the initial boundary problem of the two-dimensional density-dependent Boussinesq equations.It is shown that the solutions of the Boussinesq equations converge to those of zero thermal diffusivity Boussinesq equations as the thermal diffusivity tends to zero,and the convergence rate is established.In addition,we prove that the boundary-layer thickness is of the valueδ(k)=k^(α)with anyα∈(0,1/4)for a small diffusivity coefficient k>0,and we also find a function to describe the properties of the boundary layer.
文摘Acute promyelocytic leukemia(APL)is a special leukemia accounting for above 10%of adult acute myeloid leukemia.The t(15;17)(q22;q21)is a specific chromosome reciprocal translocation of APL,resulting in the generation of a fusion gene between a retinoic acid receptor alpha(RARα)and promyelocytic leukemia(PML)at the molecular level.Many research demonstrate that PML/RARa fusion gene can be regarded as
基金This study was supported by National Natural Science Foundation of China (81430032,111601222)the leading talents of Guangdong Province Program (No. 00201516)+3 种基金the Key Research and Development Program of Guangdong Province (2019B020235003)Guangdong Provincial Key Laboratory of Can cer Immuno therapy, Major basic research developmental project of the Natural Science Foundation of Guangdong Province (2014A030308018)Science and Tech no logy Inno vati on Committee of Shen zhe n Mun icipality (JCYJ20180504170301309)Shenzhen "Sanming" Project of Medicine (SZSM201602102).
文摘Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the genome-wide data of bin ding sites of the core pluripotency factors (SOX2, OCT4, NANOG, denoted SON), chromosomal interaction and histone modification in hESCs, we identified a potential enhancer of the GLUT1 gene in hESCs, de noted GLUT1 enhancer (GE) element GE interacts with the promoter of GLUT1, and the deletion of GE significantly reduces the expression of GLUT1, glucose uptake and glycolysis of hESCs, confirming that GE is an enhancer of GLUT1 in hESCs. In addition, the mutation of SON binding motifs within GE reduced the expression of GLUT1 as well as the interaction between GE and GLUT1 promoter, indicating that the binding of SON to GE is important for its activity. Therefore, SON promotes glucose uptake and glycolysis in hESCs by inducing GLUT1 expression through directly activating the enhancer of GLUT1.
基金This work was supported by grants from National Key Research and Development Program of China(2017YFD0200604)Key Research Program of Frontier Sciences,CAS(ZDBS-LYDQC017)+5 种基金the National Natural Science Foundation of China(41671251)Earmarked Fund for China Agriculture Research System(CR34)Heilongjiang Provincial Natural Science Foundation of China(D2018009)the Grass-field Rotation Scientist Studio of Heilongjiang Province(202004)Outstanding Youth Fund of Heilongjiang Academy of Agricultural Sciences(2020JCQN003)Youth Innovation Promotion Association,CAS(2017276).
文摘Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by monocropping.However,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been elucidated.Therefore,we investigated bacterial community structures in response to monocropped alfalfa along the chronosequence.Continuous cropping remarkably reduced bacterial alpha diversity and altered community structures,and soil pH,total P and available P were strongly associated with the changes of bacterial diversity and community structures.Intriguingly,10 years of monocropped alfalfa might be a demarcation point separating soil bacterial community structures into two obvious groups that containing soil samples collected in less and more than 10 years.The relative abundances of copiotrophic bacteria of Actinobacteria and Gammaproteobacteria significantly increased with the extension of continuous cropping years,while the oligotrophic bacteria of Armatimonadetes,Chloroflexi,Firmicutes and Gemmatimonadetes showed the opposite changing patterns.Among those altered phyla,Actinobacteria,Chloroflexi,Alphaproteobacteria and Acidobacteria were the most important bacteria which contributed 50.86%of the community variations. Additionally, the relative abundances of nitrogen fixation bacteria ofBradyrhizobium and Mesorhizobium obviously increased with continuous cropping years, while theabundances of Arthrobacter, Bacillus, Burkholderiaceae and Microbacterium with potential functionsof solubilizing phosphorus and potassium remarkably decreased after long-term continuouscropping. Furthermore, bacterial cooccurrence patterns were significantly influenced by continuouscropping years, with long-term monocropped alfalfa simplifying the complexity of the cooccurrencenetworks. These findings enhanced our understandings and provided references for forecasting howsoil bacterial communities responds to monocropped alfalfa.