Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and attacks.Traditional fingerprint r...Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and attacks.Traditional fingerprint recognition methods,which rely on preannotated feature matching,face inherent limitations due to the ever-evolving nature and diverse landscape of web applications.In response to these challenges,this work proposes an innovative web application fingerprint recognition method founded on clustering techniques.The method involves extensive data collection from the Tranco List,employing adjusted feature selection built upon Wappalyzer and noise reduction through truncated SVD dimensionality reduction.The core of the methodology lies in the application of the unsupervised OPTICS clustering algorithm,eliminating the need for preannotated labels.By transforming web applications into feature vectors and leveraging clustering algorithms,our approach accurately categorizes diverse web applications,providing comprehensive and precise fingerprint recognition.The experimental results,which are obtained on a dataset featuring various web application types,affirm the efficacy of the method,demonstrating its ability to achieve high accuracy and broad coverage.This novel approach not only distinguishes between different web application types effectively but also demonstrates superiority in terms of classification accuracy and coverage,offering a robust solution to the challenges of web application fingerprint recognition.展开更多
A novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread across the world,prompting the World Health Organization to declare the coronavirus disease of 2019(COVID-19)a public ...A novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread across the world,prompting the World Health Organization to declare the coronavirus disease of 2019(COVID-19)a public health emergency of international concern.Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms,which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment.Currently,much effort has been directed toward studying the pathogenesis and treatment of COVID-19,but the risk profiles,prognoses,and treatment outcomes in cancer patients remain unclear.Based on the current literature,we summarize the risk profiles,clinical and biochemical characteristics,and therapy outcomes of COVID-19 infections in cancer patients.The challenges in the clinical care of cancer patients with COVID-19 are discussed.The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients,thus facilitating improvement of the clinical management of these patients.展开更多
Background: Since the greater part of coronary blood flow takes place during the diastolic phase of each cardiac cycle, a time indicator of myocardial perfusion reserve, the ratio of diastolic to systolic duration (D/...Background: Since the greater part of coronary blood flow takes place during the diastolic phase of each cardiac cycle, a time indicator of myocardial perfusion reserve, the ratio of diastolic to systolic duration (D/S ratio), was presented. The objective of this study was to evaluate the accuracy and precision, the biological implication, and the applications of D/S ratio. Methods: Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve were performed. Related experiments, clinical trials, and surveys were conducted at 5 centers. Results: The results showed that the measurement of D/S ratio is both accurate and precise;the mean values of D/S of all of the 3 species studied (human, rabbit, and rat) were greater than 1. These application studies on D/S ratio showed that a close negative correlation existed between D/S ratio and New York Heart Association Functional Classification (NYHA FC) (r = –0.659, p pregnant women with pre-eclampsia and either normal pregnant women or non-pregnant women were significant (p Conclusions: D/S ratio has important biological implication, which is a safe, easy, reliable, and effective indicator, can be used to evaluate fitness levels, served as a pathophysiological marker for screening of cardiovascular disease (CVD), for predicting risk of cardiac events, and for evaluating the severity and prognosis of CVD.展开更多
Background: It is difficult to observe the phenomena of cardiac fatigue under a low or moderate workload test, and little was reported about cardiac fatigue under a heavy workload test because of the potential risk (s...Background: It is difficult to observe the phenomena of cardiac fatigue under a low or moderate workload test, and little was reported about cardiac fatigue under a heavy workload test because of the potential risk (sudden death) of prolonged strenuous exercise. Animal experiments would be helpful to resolve this problem. The objective of this study was to obtain baseline data of two new indicators of cardiac reserve in rats, rabbits, and dogs. Methods: Ten New Zealand White rabbits (1. 5 to 2 kg, 4 females), 10 male Wistar rats (2 months old), and 10 Golden Retriever dogs (40 days old, 5 females) were included in this study. Phonocardiogram of each animal was recorded. The basic points concerning heart sound quantitative analysis were: 1) measuring the duration and the amplitude of relevant heart sound components;2) calculating and analyzing relevant indicators based on the data obtained from the above measurements, including the ratio of diastolic to systolic duration (D/S) and the ratio of the amplitude of the first heart sound to the amplitude of the second heart sound (S1/S2). Results: The baseline data of D/S ratio and S1/S2 ratio in rats, rabbits, and dogs were obtained. The swimming time to exhaustion for rabbits was several to a dozen minutes, and for rats, several hours. Conclusion: D/S ratio has an important biological implication, which is a safe and easy indicator for evaluating the cardiac health status of both animals and humans.展开更多
Condemned by Mencius (ca.372-289 BCE) as selfishness (weiwo, 为我), Yang Zhu's yangsheng philosophy in China is traditionally depicted as a philosophy of egoism and hedonism. In contrast, Yang Zhu (fl.ca.370-350...Condemned by Mencius (ca.372-289 BCE) as selfishness (weiwo, 为我), Yang Zhu's yangsheng philosophy in China is traditionally depicted as a philosophy of egoism and hedonism. In contrast, Yang Zhu (fl.ca.370-350 BCE) is described as an "early liberal or individualist" hero in the Western Discussion of Chinese Philosophy. Yang Zhu may not be a liberal or individualist hero as portrayed by the West, but surely he should not be depicted as a promoter of egoism as Mencius did. Both John Emerson and A.C. Graham are probably right when they claimed that Yang Zhu was a revolutionary thinker of his own time; and "Yang Zhu's intervention for the Chinese thinking world had provoked a metaphysical crisis which had threatened the basic assumptions of Confucianism and Mohism and set them into a new course" (A.C. Graham 1978). From my reading, Yang Zhu's influence on Chinese philosophy had been and will be even greater, although his philosophy as a whole was not practiced by Chinese society in the past due to the dominance of Confucianism. Yet as the first person who clearly emphasized nourishing of life for individuals and the first theory that rooted morality into xing (性, human nature), Yang Zhu's yangsheng philosophy had indeed through history made a huge contribution to Chinese nurturing life tradition, and had great potential in providing inspiration to modern moral thinking. Many discussions initiated or developed by Yang Zhu and his followers have influenced both Confucianism and Daoism profoundly. His idea of nourishing life was not only inherited and developed by Zhuangzi and later Daoist religion from life preservation perspective, but also by Mencius and Xunzi from moral cultivation perspective. As a doctrine that has shown more and more relevance to modern society, people can find many inspirations from Yang Zhu's answer to the following questions: What is the aim of human life? What is the right attitude toward life and death? What is human nature? What is the relationship between life nourishment and individual freedom? Why nourishing one's own life should be as important as nourishing that of others? What is the difference between humans and animals? Why living a natural life is so important for human beings? Based on materials collected from various Chinese sources directly related to Yang Zhu's school, especially the chapter entitled as "Yang Zhu" from the book of Liezi, this paper will explore essential features of Yang Zhu's yangsheng philosophy and its relevance to modern society. As "guiji" (贵已, cherishing oneself) is the core of Yang Zhu's yangsheng philosophy, discussion of this paper will focus on what Yang Zhu's "guiji" means, why Yang Zhu's "guiji" is not "weiwo" (为我, for oneself), and how Yang Zhu's "guiji" yangsheng is relevant to modern society.展开更多
Achieving a straightforward design of tough,printable,and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes,and inherent c...Achieving a straightforward design of tough,printable,and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes,and inherent contrasting multiple networks.Here,we report a one-step synergistic strategy based on ruthenium chemistry-catalyzed photopolymerization and solvent effect for preparing high-performance eutectogels.This orthogonal ruthenium photochemistry helps multinetworks formation via phenol-coupling of gelatin and copolymerization of acrylamide(AAm)and[2-(methacryloyloxy)ethyl]trimethylammonium tetrafluoroborate(META)monomers in seconds.The obvious difference in the supramolecular interactions of free AAm monomers and polymerized units in P(AAm-co-META)with deep eutectic solvents(DESs)significantly promotes the microphase-separation behavior in eutectogels.Consequently,the in situ polymerization and microphase-separation behavior enable the as-prepared eutectogel materials to have excellent mechanical properties(stress of∼1.2 MPa),toughness(∼4.0 MJ m^(−3)),elasticity,adaptivity,and conductivity(∼0.5 S m^(−1)at room temperature).Also,the critical strength of the resultant eutectogels can be modulated by varying the DES constituents.This rapid and well-controlled synergistic approach is compatible with extrusion printing techniques to make flexible sensors with high sensitivities and response times to detect pressure in a range of 0–500 kPa.Such a general and simple strategy has application potential in biological,engineering,and material sciences.展开更多
Resource recycling from waste-water and sludge is an important part of the 14th Five-Year Plan in China.The emerging titanium-based coagulants have drawn growing attentions due to their strong coagulation capability i...Resource recycling from waste-water and sludge is an important part of the 14th Five-Year Plan in China.The emerging titanium-based coagulants have drawn growing attentions due to their strong coagulation capability in water purification and value-added Ti-loaded sludge production.Management and recovery of the high value-added sludge into functional nanomaterials is highly significant for both sludge reduction and environmental remediation.The present study was carried out to investigate the recycle of the coagulated Ti-loaded sludge to produce functional C/TiO_(2)composites as the anode materials for lithium-ion batteries(LIBs).It is the first time that the application of the Ti-loaded wastewater sludge derived C/TiO_(2)was evaluated for LIBs.The experimental results showed that the carbon coating through in-situ carbonization of the sludge produced the C/TiO_(2)composites with a high specific surface area,stable structural integrity,and excellent electrochemical properties that would facilitate Li+diffusion in long-term LIBs usage.The C/TiO_(2)composites calcinated from the polytitanium sulfate-coagulated sludge at 800℃(N_(2))exhibited the best electrochemical performance during the cycling tests(601 m Ah/g at 100 m A/g after 200 cycles).The research work demonstrates the promising prospect of the recycle and value-added utilization of the Ti-loaded sludge in the production of high-performance C/TiO_(2)composites for energy storage applications.This study provides a new way for the management and reuse of Ti-loaded waste-sludge.展开更多
Objective: The medicinal mushroom Sanghuangporus vaninii produces pharmaceutically valuable hispidin polyphenols in natural habitats. However, due to the slow growth in nature, S. vaninii grown in the field(sclerotia)...Objective: The medicinal mushroom Sanghuangporus vaninii produces pharmaceutically valuable hispidin polyphenols in natural habitats. However, due to the slow growth in nature, S. vaninii grown in the field(sclerotia) is not reliable for pharmaceutical purposes. Although higher biomass of fungal mycelia can be obtained in submerged cultures, the accumulation of hispidin polyphenols is rare.Methods: In this study, the polyunsaturated fatty acids(PUFAs), linoleic acid(LA), linolenic acid(ALA),and methyl jasmonate(Me Ja) were employed as the stimulant agents to coordinate the accumulation of biomass and hispidin polyphenols in its submerged cultures.Results: The addition of LA and ALA promoted the mycelial accumulation, while the addition of Me Ja inhibited the growth of S. vaninii concomitant with reduced total polyphenols. UPLC-Triple-TOF-MS analysis revealed an increased production of hispidin, phellinstatin, pinnilidine, and its derivatives upon the addition of LA and ALA, and hypholomine B and its isomer, 3,14’-bihispidinyl, and phelligridin E upon the addition of Me Ja on day 13. Intriguingly, total polyphenols from the Me Ja-supplementing cultures harbored a high capacity in scavenging free radicals. Chemical structural analysis showed that hispidin polyphenols had higher antioxidant activity due to more hispidin moieties induced by Me Ja.Conclusion: The supplement of PUFAs affects the synthesis and composition of hispidin polyphenols in S.vaninii. Our results provide a possibility to coordinate the production of hispidin polyphenols via submerged cultures of S. vaninii.展开更多
Photocatalytic membranes offer an effective strategy to overcome the difficulties of solid-liquid separation and secondary contamination of powdered photocatalysts.MXene is a 2D material of layered Ti_(3)C_(2),which i...Photocatalytic membranes offer an effective strategy to overcome the difficulties of solid-liquid separation and secondary contamination of powdered photocatalysts.MXene is a 2D material of layered Ti_(3)C_(2),which is considered to limit electron-hole separation and contribute to photocatalysis.In this work,the etched Ti_(3)C_(2) MXene was loaded on the surface of ceramic membranes using polydopamine(PDA)as a binder,followed by one-step calcination to produce TiO_(2) nanoparticles(NPs)in situ.The characterizations supported that the TiO_(2)/Ti_(3)C_(2) ceramic membranes had high mechanical strength while retaining the layered structure of Ti_(3)C_(2),which was conducive to the inhibition of electron and hole complexation,improving the photocatalytic performance.Degradation experiments revealed that the material showed enhanced degradation of pharmaceuticals and personal care products(PPCPs)such as ciprofloxacin(CIP),tetracycline(TCN)and ibuprofen(IBP).The LC-MS and toxicity prediction models indicated that the developmental toxicity of CIP degradation products decreased with prolonged photocatalytic reaction,exhibiting no acute toxicity to fish.The MT650 exhibited significantly enhanced water flux properties(320 L/(m^(2)·h).The TiO_(2)/Ti_(3)C_(2) ceramic membranes explored in this work are expected to target the treatment of PPCPs with excellent engineering promise.展开更多
Interest in the development of inorganic polymerized coagulants is growing; however, there are only limited studies on the synthesis of polytitanium coagulants, which are expected to exhibit improved coagulation effic...Interest in the development of inorganic polymerized coagulants is growing; however, there are only limited studies on the synthesis of polytitanium coagulants, which are expected to exhibit improved coagulation efficiency with better floc properties. This study presents the synthesis of polytitanium sulfate(PTS) for potential application in water purification,followed by characterization of PTS flocs and titanium species detection. Stable PTS solutions were successfully synthesized and standard jar tests were conducted to evaluate their coagulation efficiency. Electrospray ionization time-of-flight mass spectrometry(ESI-TOF-MS) speciation analysis revealed that a variety of mononuclear and polynuclear complexes were formed in PTS solution, indicating the polymeric nature of the synthesized coagulant. Floc characteristics were studied through on-line monitoring of floc size using a laser diffraction particle size analyzer. Results showed that PTS had a comparable or in some cases even higher organic matter and particulate removal efficiency than Ti(SO4)2.The effluent p H after PTS coagulation significantly improved toward desirable values closer to neutral p H. Properties of flocs formed by PTS were significantly improved in terms of floc size, growth rate and structure. This study showed that PTS could be an efficient and promising coagulant for water purification, with the additional benefit that its coagulated sludge can be used to recover valuable TiO2 nanoparticles for various commercial applications.展开更多
A novel flocculant LA (lignin-acrylamide polymer), which was used as aid for aluminum sulfate and polyaluminum chloride in this study, was prepared by grafting acrylamide onto lignin that deriving from pulp and pape...A novel flocculant LA (lignin-acrylamide polymer), which was used as aid for aluminum sulfate and polyaluminum chloride in this study, was prepared by grafting acrylamide onto lignin that deriving from pulp and papermaking sludge. Physicochemical properties of LA were measured by X-ray photoelectron spectroscopy and scanning electron microscopy. The experimental outcome indicated acrylamide was grafted onto the lignin backbone successfully. The effects of LA addition were evaluated on coagulation performance and floc characteristics as a function of aluminum (Al) dosage, such as floc size, growth rate, strength and recoverability. Effects of different dosing sequences, Al dosed first and LA dosed first, were also investigated. LA used as coagulant aid markedly enhanced the removal efficiency of turbidity and dissolved organic carbon, especially at low Al dosages. The dissolved organic carbon removal efficiencies of aluminum sulfate and polyaluminum chloride at the Al dosage range selected in this study were improved more than 30% and 5% by LA, respectively. LA dramatically enlarged floc size and it was in the order: Al dosed first 〉 LA dosed first 〉 Al. Floc strength and recoverability were also improved by LA. LA played a significant role in charge neutralization, adsorption and bridging in floc formation.展开更多
Background:Primary human papillomavirus(HPV)screening is recommended for the detection of cervical intraepithelial neoplasia(CIN)in the general pop-ulation;however,the triage for HPV-positive women remains a challenge...Background:Primary human papillomavirus(HPV)screening is recommended for the detection of cervical intraepithelial neoplasia(CIN)in the general pop-ulation;however,the triage for HPV-positive women remains a challenge.This study aimed to evaluate the age-specific effectiveness of primary HPV screening versus primary cytology screening for identifying optimal strategies for women of different ages.Methods:The dataset of the prevalence round screening was derived from the National Cervical Cancer Screening Program in China.Primary cervical screen-ing protocols included cytology only,HPV testing with cytology triage,and HPV testing with HPV-16/18 genotyping plus cytology triage.The primary outcomes were age-specific detection rate,colposcopy referral rate and positive predictive value(PPV)for CIN2+.Multivariate Poisson regression was used to evaluate the relativeeffectivenessofHPVtestingandcytologyaccordingtoagegroups.TheI 2 statisticwitharandom-effectmodelwasusedtotesttheheterogeneityinrelative effectiveness of HPV testing versus cytology between age groups.Results:This study included 1,160,981 women.HPV testing with HPV-16/18 genotyping plus cytology triage significantly increased the CIN2+detection by 36%(rate ratio[RR]:1.36,95%confidential interval[CI]1.21–1.54)for women aged 35-44 years and by 34%(RR:1.34,95%CI 1.20-1.51)for women aged 45-54 years compared with cytology only.HPV testing with cytology triage had simi-lar CIN2+detection rate compared with cytology only.The PPVs were substan-tially increased for both HPV testing groups.Among women aged 55-64 years old,HPV testing with HPV-16/18 genotyping plus cytology triage increased the colposcopyreferralrateby19%(RR1.19,95%CI1.10-1.29)comparedwithcytology only,butdidnotincreasetheCIN2+detection(1.09,0.91–1.30).Theeffectiveness ofHPVtestingwithcytologytriagedidnotchangeinolderwomen.Thebetween-age-group heterogeneity in the effectiveness was statistically significant for HPV testing with HPV-16/18 genotyping plus cytology triage versus cytology only.Conclusions:Our results suggested that the effectiveness of primary HPV screeningwithdifferenttriagestrategiesdifferedamongagegroups.HPVtesting with HPV-16/18 genotyping plus cytology triage could be used for women aged 35-54 years to detect more lesions,and HPV testing with cytology triage could balance the CIN2+detection and the number of colposcopies for women aged 55-64 years.Longitudinal data including both prevalence and incidence screen-ing rounds are warranted to assess age-specific triage strategies.展开更多
Application of ceramic membrane(CM)with outstanding characteristics,such as high flux and chemical-resistance,is inevitably restricted by membrane fouling.Coagulation was an economical and effective technology for mem...Application of ceramic membrane(CM)with outstanding characteristics,such as high flux and chemical-resistance,is inevitably restricted by membrane fouling.Coagulation was an economical and effective technology for membrane fouling control.This study investigated the filtration performance of ceramic membrane enhanced by the emerging titanium-based coagulant(polytitanium chloride,PTC).Particular attention was paid to the simulation of ceramic membrane fouling using four widely used mathematical models.Results show that filtration of the PTC-coagulated effluent using flat-sheet ceramic membrane achieved the removal of organic matter up to 78.0%.Permeate flux of ceramic membrane filtration reached 600 L/(m2$h),which was 10-fold higher than that observed with conventional polyaluminum chloride(PAC)case.For PTC,fouling of the ceramic membrane was attributed to the formation of cake layer,whereas for PAC,standard filtration/intermediate filtration(blocking of membrane pores)was also a key fouling mechanism.To sum up,cross-flow filtration with flat-sheet ceramic membranes could be significantly enhanced by titanium-based coagulation to produce both high-quality filtrate and high-permeation flux.展开更多
Achieving hydrogen production and simultaneous decomposition of organic pollutants through dual-functional photocatalytic reactions has received increasing attention due to the environmentally friendly and cost-effect...Achieving hydrogen production and simultaneous decomposition of organic pollutants through dual-functional photocatalytic reactions has received increasing attention due to the environmentally friendly and cost-effective characteristics of this approach.In this work,an urchin-like oxygen-doped MoS_(2)/ZnIn_(2)S_(4)(OMS/ZIS)composite was fabricated for the first time using a simple solvothermal method.The unique microstructure with abundant active sites and fast charge transfer channels further shortened the charge migration distance and compressed carrier recombination.The obtained composite exhibited an efficient H2 evolution reaction rate of 12.8 mmol/g/h under visible light,which was nearly times higher than pristine ZnIn_(2)S_(4),and the apparent quantum efficiency was 14.9%(420 nm).The results of the simultaneous photocatalytic H2 evolution and organic pollutant decomposition test were satisfactory,resulting in decomposition efficiencies of resorcinol,tetracycline,and bisphenol A that reached 41.5%,63.5%,and 53.0%after 4 h,respectively,and the highest H2 evolution rate was 672.7 umol/g/h for bisphenol A.Furthermore,natural organic matter(NOM)abundantly found in actual water was adopted as an electron donor for H production under simulated sunlight irradiation,indicating the promising practicability of simultaneous hydrogen evolution and NOM decomposition.Moreover,the mechanisms of the dual-purpose photocatalytic reactions,as well as the synergistic effect between the molecular structures of the organic pollutants and the corresponding adsorption behavior on the photocatalyst surface were illustrated in detail.These obtained results may serve as an inspiration for the rational design of highly efficient,dual-functional photocatalysts in the future.展开更多
Measuring the impacts of uncertainties identified from different global climate models(GCMs),representative concentration pathways(RCPs),and parameters of statistical crop models on the projected effects of climate ch...Measuring the impacts of uncertainties identified from different global climate models(GCMs),representative concentration pathways(RCPs),and parameters of statistical crop models on the projected effects of climate change on crop yields can help to improve the availability of simulation results.The quantification and separation of different sources of uncertainty also help to improve understanding of impacts of uncertainties and provide a theoretical basis for their reduction.In this study,uncertainties of maize yield predictions are evaluated by using 30 sets of parameters from statistical crop models together with eight GCMs with reference to three emission scenarios for Jilin Province of northeastern China.Regression models using replicates based on bootstrap resampling reveal that yields are maximized when the optimum average growing season temperature is 20.1°C for 1990–2009.The results of multi-model ensemble simulations show a maize yield reduction of 11%,with 75%probability for 2040–69 relative to the baseline period of 1976–2005.We decompose the variance so as to understand the relative importance of different sources of uncertainty,such as GCMs,RCPs,and statistical model parameters.The greatest proportion of uncertainty(>50%)is derived from GCMs,followed by RCPs with a proportion of 28%and statistical crop model parameters with a proportion of 20%of total ensemble uncertainty.展开更多
Background:Aurora kinases(AURKs)family plays a vital role not only in cell division but also in tumorigenesis.However,there are still rare systematic analyses of the diverse expression patterns and prognostic value of...Background:Aurora kinases(AURKs)family plays a vital role not only in cell division but also in tumorigenesis.However,there are still rare systematic analyses of the diverse expression patterns and prognostic value of the AURKs family in breast cancer(BC).Systematic bioinformatics analysis was conducted to explore the biological role,prognostic value,and immunologic function of AURKs family in BC.Methods:The expression,prognostic value,and clinical functions of AURKs family in BC were evaluated with several bioinformatics web portals:ONCOMINE Gene Expression Profiling Interactive Analysis,Kaplan-Meier plotter,cBioPortal,Metascape,GeneMANIA,and LinkedOmics;and the result was verified using human tissues.Results:The expression of AURKA and AURKB were upregulated in BC in subgroup analyses based on tumor stage(all P<0.05).BC patients with high AURKA and AURKB expression had a worse overall survival,relapse-free survival,and distant metastasisfree survival(all P<0.05).Verification experiment revealed that AURKA and AURKB were upregulated in BC(P<0.05).AURKA and AURKB were specifically associated with several tumor-associated kinases(polo-like kinase 1 and cyclin-dependent kinase 1),miRNAs(miR-507 and miR-381),and E2F transcription factor 1.Moreover,AURKA and AURKB were correlated with immune cell infiltration.Functional enrichment analysis revealed that AURKA and AURKB were involved in the cell cycle signaling pathway,platinum drug resistance signaling pathway,ErbB signaling pathway,Hippo signaling pathway,and nucleotide-binding and oligomerization domain-like receptor signaling pathway.Conclusions:Aurora kinases AURKA and AURKB could be employed as novel prognostic biomarkers or promising therapeutic targets for BC.展开更多
Titanium-based coagulation has proved to be effective for algae-laden micro-polluted water purification processes.However,the influence of algae inclusion in surface water treatment by titanium coagulation is barely r...Titanium-based coagulation has proved to be effective for algae-laden micro-polluted water purification processes.However,the influence of algae inclusion in surface water treatment by titanium coagulation is barely reported.This study reports the influence of both Microcystis aeruginosa and Microcystis wesenbergii in surface water during polytitanium coagulation.Jar tests were performed to evaluate coagulation performance using both algae-free(controlled)and algae-laden water samples,and floc properties were studied using a laser diffraction particle size analyzer for online monitoring.Results show that polytitanium coagulation can be highly effective in algae separation,removing up to 98%from surface water.Additionally,the presence of algae enhanced organic matter removal by up to 30%compared to controlled water containing only organic matter.Polytitanium coagulation achieved significant removal of fluorescent organic materials and organic matter with a wide range of molecular weight distribution(693–4945 Da)even in the presence of algae species in surface water.The presence of algae cells and/or algal organic matter is likely to function as an additional coagulant or flocculation aid,assisting polytitanium coagulation through adsorption and bridging effects.Although the dominant coagulation mechanisms with polytitanium coagulant were influenced by the coagulant dosage and initial solution pH,algae species in surface water could enhance the charge neutralization capability of the polytitanium coagulant.Algae-rich flocs were also more prone to breakage with strength factors approximately 10%lower than those of algae-free flocs.Loose structure of the flocs will require careful handling of the flocs during coagulation-sedimentation-filtration processes.展开更多
Most studies do not consider the potential variation in carbon concentration among the different tree components of the same species in regional scale. This study examined the carbon concentrations of the compo- nents...Most studies do not consider the potential variation in carbon concentration among the different tree components of the same species in regional scale. This study examined the carbon concentrations of the compo- nents (i.e., foliage, branch, stem, and root) in a 10-year-old poplar species (Populus davidiana Dode) from the Desertification Combating Program of Northern China. The highest and lowest carbon concentrations were found in the stem and foliage, respectively. There was a significant difference in carbon concentrations among the different tree components. All of the observed carbon concentrations of tree components were lower than those predicted using the conversion factor of 0.5 applied to component biomass. Stem carbon made up 59.7% of the total tree biomass carbon. The power equation estimating proportion of tree biomass carbon against the independent variable of diameter at breast height explained more than 90% of the variability in allocation of carbon among tree components. Tree height, as a second independent variable is also discussed. Our results suggest that the difference in organic carbon concentration among tree components should be incorporated into accurately develop forest carbon budget. Moreover, further investigations on how the diameter at breast height equation developed in the present study performs across broader scales are required.展开更多
基金supported in part by the National Science Foundation of China under Grants U22B2027,62172297,62102262,61902276 and 62272311,Tianjin Intelligent Manufacturing Special Fund Project under Grant 20211097the China Guangxi Science and Technology Plan Project(Guangxi Science and Technology Base and Talent Special Project)under Grant AD23026096(Application Number 2022AC20001)+1 种基金Hainan Provincial Natural Science Foundation of China under Grant 622RC616CCF-Nsfocus Kunpeng Fund Project under Grant CCF-NSFOCUS202207.
文摘Web application fingerprint recognition is an effective security technology designed to identify and classify web applications,thereby enhancing the detection of potential threats and attacks.Traditional fingerprint recognition methods,which rely on preannotated feature matching,face inherent limitations due to the ever-evolving nature and diverse landscape of web applications.In response to these challenges,this work proposes an innovative web application fingerprint recognition method founded on clustering techniques.The method involves extensive data collection from the Tranco List,employing adjusted feature selection built upon Wappalyzer and noise reduction through truncated SVD dimensionality reduction.The core of the methodology lies in the application of the unsupervised OPTICS clustering algorithm,eliminating the need for preannotated labels.By transforming web applications into feature vectors and leveraging clustering algorithms,our approach accurately categorizes diverse web applications,providing comprehensive and precise fingerprint recognition.The experimental results,which are obtained on a dataset featuring various web application types,affirm the efficacy of the method,demonstrating its ability to achieve high accuracy and broad coverage.This novel approach not only distinguishes between different web application types effectively but also demonstrates superiority in terms of classification accuracy and coverage,offering a robust solution to the challenges of web application fingerprint recognition.
基金supported by the National Institutes of Health(Grant No.2R01CA151610)Department of Defense(Grant No.W81XWH-18-1-0067)a Samuel Oschin Cancer Institute Discovery Fund Award and Community Outreach and Engagement Developmental Fund Award.
文摘A novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread across the world,prompting the World Health Organization to declare the coronavirus disease of 2019(COVID-19)a public health emergency of international concern.Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms,which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment.Currently,much effort has been directed toward studying the pathogenesis and treatment of COVID-19,but the risk profiles,prognoses,and treatment outcomes in cancer patients remain unclear.Based on the current literature,we summarize the risk profiles,clinical and biochemical characteristics,and therapy outcomes of COVID-19 infections in cancer patients.The challenges in the clinical care of cancer patients with COVID-19 are discussed.The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients,thus facilitating improvement of the clinical management of these patients.
文摘Background: Since the greater part of coronary blood flow takes place during the diastolic phase of each cardiac cycle, a time indicator of myocardial perfusion reserve, the ratio of diastolic to systolic duration (D/S ratio), was presented. The objective of this study was to evaluate the accuracy and precision, the biological implication, and the applications of D/S ratio. Methods: Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve were performed. Related experiments, clinical trials, and surveys were conducted at 5 centers. Results: The results showed that the measurement of D/S ratio is both accurate and precise;the mean values of D/S of all of the 3 species studied (human, rabbit, and rat) were greater than 1. These application studies on D/S ratio showed that a close negative correlation existed between D/S ratio and New York Heart Association Functional Classification (NYHA FC) (r = –0.659, p pregnant women with pre-eclampsia and either normal pregnant women or non-pregnant women were significant (p Conclusions: D/S ratio has important biological implication, which is a safe, easy, reliable, and effective indicator, can be used to evaluate fitness levels, served as a pathophysiological marker for screening of cardiovascular disease (CVD), for predicting risk of cardiac events, and for evaluating the severity and prognosis of CVD.
文摘Background: It is difficult to observe the phenomena of cardiac fatigue under a low or moderate workload test, and little was reported about cardiac fatigue under a heavy workload test because of the potential risk (sudden death) of prolonged strenuous exercise. Animal experiments would be helpful to resolve this problem. The objective of this study was to obtain baseline data of two new indicators of cardiac reserve in rats, rabbits, and dogs. Methods: Ten New Zealand White rabbits (1. 5 to 2 kg, 4 females), 10 male Wistar rats (2 months old), and 10 Golden Retriever dogs (40 days old, 5 females) were included in this study. Phonocardiogram of each animal was recorded. The basic points concerning heart sound quantitative analysis were: 1) measuring the duration and the amplitude of relevant heart sound components;2) calculating and analyzing relevant indicators based on the data obtained from the above measurements, including the ratio of diastolic to systolic duration (D/S) and the ratio of the amplitude of the first heart sound to the amplitude of the second heart sound (S1/S2). Results: The baseline data of D/S ratio and S1/S2 ratio in rats, rabbits, and dogs were obtained. The swimming time to exhaustion for rabbits was several to a dozen minutes, and for rats, several hours. Conclusion: D/S ratio has an important biological implication, which is a safe and easy indicator for evaluating the cardiac health status of both animals and humans.
文摘Condemned by Mencius (ca.372-289 BCE) as selfishness (weiwo, 为我), Yang Zhu's yangsheng philosophy in China is traditionally depicted as a philosophy of egoism and hedonism. In contrast, Yang Zhu (fl.ca.370-350 BCE) is described as an "early liberal or individualist" hero in the Western Discussion of Chinese Philosophy. Yang Zhu may not be a liberal or individualist hero as portrayed by the West, but surely he should not be depicted as a promoter of egoism as Mencius did. Both John Emerson and A.C. Graham are probably right when they claimed that Yang Zhu was a revolutionary thinker of his own time; and "Yang Zhu's intervention for the Chinese thinking world had provoked a metaphysical crisis which had threatened the basic assumptions of Confucianism and Mohism and set them into a new course" (A.C. Graham 1978). From my reading, Yang Zhu's influence on Chinese philosophy had been and will be even greater, although his philosophy as a whole was not practiced by Chinese society in the past due to the dominance of Confucianism. Yet as the first person who clearly emphasized nourishing of life for individuals and the first theory that rooted morality into xing (性, human nature), Yang Zhu's yangsheng philosophy had indeed through history made a huge contribution to Chinese nurturing life tradition, and had great potential in providing inspiration to modern moral thinking. Many discussions initiated or developed by Yang Zhu and his followers have influenced both Confucianism and Daoism profoundly. His idea of nourishing life was not only inherited and developed by Zhuangzi and later Daoist religion from life preservation perspective, but also by Mencius and Xunzi from moral cultivation perspective. As a doctrine that has shown more and more relevance to modern society, people can find many inspirations from Yang Zhu's answer to the following questions: What is the aim of human life? What is the right attitude toward life and death? What is human nature? What is the relationship between life nourishment and individual freedom? Why nourishing one's own life should be as important as nourishing that of others? What is the difference between humans and animals? Why living a natural life is so important for human beings? Based on materials collected from various Chinese sources directly related to Yang Zhu's school, especially the chapter entitled as "Yang Zhu" from the book of Liezi, this paper will explore essential features of Yang Zhu's yangsheng philosophy and its relevance to modern society. As "guiji" (贵已, cherishing oneself) is the core of Yang Zhu's yangsheng philosophy, discussion of this paper will focus on what Yang Zhu's "guiji" means, why Yang Zhu's "guiji" is not "weiwo" (为我, for oneself), and how Yang Zhu's "guiji" yangsheng is relevant to modern society.
基金the National Natural Science Foundation of China(grant nos.22175141 and 12102342)the Nature Science Foundation of Shaanxi Province(grant nos.2023-JC-JQ-14,2023JC-XJ-21,and 2022JQ-146)+1 种基金Cultivation Program for the Excellent Doctoral Dissertation of Northwest University(grant no.YB2023006)the Young Elite Scientists Sponsorship Program by Xi’an Association for Science and Technology(grant no.095920221324)for the financial support of this work.
文摘Achieving a straightforward design of tough,printable,and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes,and inherent contrasting multiple networks.Here,we report a one-step synergistic strategy based on ruthenium chemistry-catalyzed photopolymerization and solvent effect for preparing high-performance eutectogels.This orthogonal ruthenium photochemistry helps multinetworks formation via phenol-coupling of gelatin and copolymerization of acrylamide(AAm)and[2-(methacryloyloxy)ethyl]trimethylammonium tetrafluoroborate(META)monomers in seconds.The obvious difference in the supramolecular interactions of free AAm monomers and polymerized units in P(AAm-co-META)with deep eutectic solvents(DESs)significantly promotes the microphase-separation behavior in eutectogels.Consequently,the in situ polymerization and microphase-separation behavior enable the as-prepared eutectogel materials to have excellent mechanical properties(stress of∼1.2 MPa),toughness(∼4.0 MJ m^(−3)),elasticity,adaptivity,and conductivity(∼0.5 S m^(−1)at room temperature).Also,the critical strength of the resultant eutectogels can be modulated by varying the DES constituents.This rapid and well-controlled synergistic approach is compatible with extrusion printing techniques to make flexible sensors with high sensitivities and response times to detect pressure in a range of 0–500 kPa.Such a general and simple strategy has application potential in biological,engineering,and material sciences.
基金supported by grants from the Taishan Scholars Young Experts Program (No.tsqn202103080)The National Natural Science Foundation of China (No.51978311)+1 种基金the Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program (No.2021KJ043)the Research Grants Council of the Hong Kong SAR Government (Nos.17210219 and T21-711/16-R)。
文摘Resource recycling from waste-water and sludge is an important part of the 14th Five-Year Plan in China.The emerging titanium-based coagulants have drawn growing attentions due to their strong coagulation capability in water purification and value-added Ti-loaded sludge production.Management and recovery of the high value-added sludge into functional nanomaterials is highly significant for both sludge reduction and environmental remediation.The present study was carried out to investigate the recycle of the coagulated Ti-loaded sludge to produce functional C/TiO_(2)composites as the anode materials for lithium-ion batteries(LIBs).It is the first time that the application of the Ti-loaded wastewater sludge derived C/TiO_(2)was evaluated for LIBs.The experimental results showed that the carbon coating through in-situ carbonization of the sludge produced the C/TiO_(2)composites with a high specific surface area,stable structural integrity,and excellent electrochemical properties that would facilitate Li+diffusion in long-term LIBs usage.The C/TiO_(2)composites calcinated from the polytitanium sulfate-coagulated sludge at 800℃(N_(2))exhibited the best electrochemical performance during the cycling tests(601 m Ah/g at 100 m A/g after 200 cycles).The research work demonstrates the promising prospect of the recycle and value-added utilization of the Ti-loaded sludge in the production of high-performance C/TiO_(2)composites for energy storage applications.This study provides a new way for the management and reuse of Ti-loaded waste-sludge.
基金supported by National Natural Science Foundation of China (No. 31170063 and 31470173) for Weifa Zheng。
文摘Objective: The medicinal mushroom Sanghuangporus vaninii produces pharmaceutically valuable hispidin polyphenols in natural habitats. However, due to the slow growth in nature, S. vaninii grown in the field(sclerotia) is not reliable for pharmaceutical purposes. Although higher biomass of fungal mycelia can be obtained in submerged cultures, the accumulation of hispidin polyphenols is rare.Methods: In this study, the polyunsaturated fatty acids(PUFAs), linoleic acid(LA), linolenic acid(ALA),and methyl jasmonate(Me Ja) were employed as the stimulant agents to coordinate the accumulation of biomass and hispidin polyphenols in its submerged cultures.Results: The addition of LA and ALA promoted the mycelial accumulation, while the addition of Me Ja inhibited the growth of S. vaninii concomitant with reduced total polyphenols. UPLC-Triple-TOF-MS analysis revealed an increased production of hispidin, phellinstatin, pinnilidine, and its derivatives upon the addition of LA and ALA, and hypholomine B and its isomer, 3,14’-bihispidinyl, and phelligridin E upon the addition of Me Ja on day 13. Intriguingly, total polyphenols from the Me Ja-supplementing cultures harbored a high capacity in scavenging free radicals. Chemical structural analysis showed that hispidin polyphenols had higher antioxidant activity due to more hispidin moieties induced by Me Ja.Conclusion: The supplement of PUFAs affects the synthesis and composition of hispidin polyphenols in S.vaninii. Our results provide a possibility to coordinate the production of hispidin polyphenols via submerged cultures of S. vaninii.
基金supported by the grants from the Taishan Scholars Young Experts Program(China)(No.tsqn202103080)the Shandong Province Higher Educational Youth Innovation Science and Technology Program(China)(No.2021KJ043)the National Natural Science Foundation of China(No.51978311).
文摘Photocatalytic membranes offer an effective strategy to overcome the difficulties of solid-liquid separation and secondary contamination of powdered photocatalysts.MXene is a 2D material of layered Ti_(3)C_(2),which is considered to limit electron-hole separation and contribute to photocatalysis.In this work,the etched Ti_(3)C_(2) MXene was loaded on the surface of ceramic membranes using polydopamine(PDA)as a binder,followed by one-step calcination to produce TiO_(2) nanoparticles(NPs)in situ.The characterizations supported that the TiO_(2)/Ti_(3)C_(2) ceramic membranes had high mechanical strength while retaining the layered structure of Ti_(3)C_(2),which was conducive to the inhibition of electron and hole complexation,improving the photocatalytic performance.Degradation experiments revealed that the material showed enhanced degradation of pharmaceuticals and personal care products(PPCPs)such as ciprofloxacin(CIP),tetracycline(TCN)and ibuprofen(IBP).The LC-MS and toxicity prediction models indicated that the developmental toxicity of CIP degradation products decreased with prolonged photocatalytic reaction,exhibiting no acute toxicity to fish.The MT650 exhibited significantly enhanced water flux properties(320 L/(m^(2)·h).The TiO_(2)/Ti_(3)C_(2) ceramic membranes explored in this work are expected to target the treatment of PPCPs with excellent engineering promise.
基金supported by the National Natural Science Foundation of China(Nos.51278283 and 51508308)the China Postdoctoral Science Foundation(Nos.2014M560557 and2015T80722)+1 种基金the Tai Shan Scholar Foundation(No.ts201511003)Hong Kong Scholars Program
文摘Interest in the development of inorganic polymerized coagulants is growing; however, there are only limited studies on the synthesis of polytitanium coagulants, which are expected to exhibit improved coagulation efficiency with better floc properties. This study presents the synthesis of polytitanium sulfate(PTS) for potential application in water purification,followed by characterization of PTS flocs and titanium species detection. Stable PTS solutions were successfully synthesized and standard jar tests were conducted to evaluate their coagulation efficiency. Electrospray ionization time-of-flight mass spectrometry(ESI-TOF-MS) speciation analysis revealed that a variety of mononuclear and polynuclear complexes were formed in PTS solution, indicating the polymeric nature of the synthesized coagulant. Floc characteristics were studied through on-line monitoring of floc size using a laser diffraction particle size analyzer. Results showed that PTS had a comparable or in some cases even higher organic matter and particulate removal efficiency than Ti(SO4)2.The effluent p H after PTS coagulation significantly improved toward desirable values closer to neutral p H. Properties of flocs formed by PTS were significantly improved in terms of floc size, growth rate and structure. This study showed that PTS could be an efficient and promising coagulant for water purification, with the additional benefit that its coagulated sludge can be used to recover valuable TiO2 nanoparticles for various commercial applications.
文摘A novel flocculant LA (lignin-acrylamide polymer), which was used as aid for aluminum sulfate and polyaluminum chloride in this study, was prepared by grafting acrylamide onto lignin that deriving from pulp and papermaking sludge. Physicochemical properties of LA were measured by X-ray photoelectron spectroscopy and scanning electron microscopy. The experimental outcome indicated acrylamide was grafted onto the lignin backbone successfully. The effects of LA addition were evaluated on coagulation performance and floc characteristics as a function of aluminum (Al) dosage, such as floc size, growth rate, strength and recoverability. Effects of different dosing sequences, Al dosed first and LA dosed first, were also investigated. LA used as coagulant aid markedly enhanced the removal efficiency of turbidity and dissolved organic carbon, especially at low Al dosages. The dissolved organic carbon removal efficiencies of aluminum sulfate and polyaluminum chloride at the Al dosage range selected in this study were improved more than 30% and 5% by LA, respectively. LA dramatically enlarged floc size and it was in the order: Al dosed first 〉 LA dosed first 〉 Al. Floc strength and recoverability were also improved by LA. LA played a significant role in charge neutralization, adsorption and bridging in floc formation.
基金NationalNatural Science Foundation of China,Grant/Award Number:81903328Key Project of PublicHealth Program+2 种基金study was supported by grants from the National Nat-ural Science Foundation of China(grant no 81903328)and the Chinese Key Project of Public Health Program.The funderswere not involved in the design,conduct,or report-ing of the studythe writing of the manuscriptor the deci-sion to publish the manuscript.
文摘Background:Primary human papillomavirus(HPV)screening is recommended for the detection of cervical intraepithelial neoplasia(CIN)in the general pop-ulation;however,the triage for HPV-positive women remains a challenge.This study aimed to evaluate the age-specific effectiveness of primary HPV screening versus primary cytology screening for identifying optimal strategies for women of different ages.Methods:The dataset of the prevalence round screening was derived from the National Cervical Cancer Screening Program in China.Primary cervical screen-ing protocols included cytology only,HPV testing with cytology triage,and HPV testing with HPV-16/18 genotyping plus cytology triage.The primary outcomes were age-specific detection rate,colposcopy referral rate and positive predictive value(PPV)for CIN2+.Multivariate Poisson regression was used to evaluate the relativeeffectivenessofHPVtestingandcytologyaccordingtoagegroups.TheI 2 statisticwitharandom-effectmodelwasusedtotesttheheterogeneityinrelative effectiveness of HPV testing versus cytology between age groups.Results:This study included 1,160,981 women.HPV testing with HPV-16/18 genotyping plus cytology triage significantly increased the CIN2+detection by 36%(rate ratio[RR]:1.36,95%confidential interval[CI]1.21–1.54)for women aged 35-44 years and by 34%(RR:1.34,95%CI 1.20-1.51)for women aged 45-54 years compared with cytology only.HPV testing with cytology triage had simi-lar CIN2+detection rate compared with cytology only.The PPVs were substan-tially increased for both HPV testing groups.Among women aged 55-64 years old,HPV testing with HPV-16/18 genotyping plus cytology triage increased the colposcopyreferralrateby19%(RR1.19,95%CI1.10-1.29)comparedwithcytology only,butdidnotincreasetheCIN2+detection(1.09,0.91–1.30).Theeffectiveness ofHPVtestingwithcytologytriagedidnotchangeinolderwomen.Thebetween-age-group heterogeneity in the effectiveness was statistically significant for HPV testing with HPV-16/18 genotyping plus cytology triage versus cytology only.Conclusions:Our results suggested that the effectiveness of primary HPV screeningwithdifferenttriagestrategiesdifferedamongagegroups.HPVtesting with HPV-16/18 genotyping plus cytology triage could be used for women aged 35-54 years to detect more lesions,and HPV testing with cytology triage could balance the CIN2+detection and the number of colposcopies for women aged 55-64 years.Longitudinal data including both prevalence and incidence screen-ing rounds are warranted to assess age-specific triage strategies.
基金This work was supported by the National Natural Science Foundation of China(Grant No.51978311)Taishan Scholars Young Experts Program(China)(No.tsqn202103080)Shandong Provincial Natural Science Foundation,China(No.ZR2019BEE044).
文摘Application of ceramic membrane(CM)with outstanding characteristics,such as high flux and chemical-resistance,is inevitably restricted by membrane fouling.Coagulation was an economical and effective technology for membrane fouling control.This study investigated the filtration performance of ceramic membrane enhanced by the emerging titanium-based coagulant(polytitanium chloride,PTC).Particular attention was paid to the simulation of ceramic membrane fouling using four widely used mathematical models.Results show that filtration of the PTC-coagulated effluent using flat-sheet ceramic membrane achieved the removal of organic matter up to 78.0%.Permeate flux of ceramic membrane filtration reached 600 L/(m2$h),which was 10-fold higher than that observed with conventional polyaluminum chloride(PAC)case.For PTC,fouling of the ceramic membrane was attributed to the formation of cake layer,whereas for PAC,standard filtration/intermediate filtration(blocking of membrane pores)was also a key fouling mechanism.To sum up,cross-flow filtration with flat-sheet ceramic membranes could be significantly enhanced by titanium-based coagulation to produce both high-quality filtrate and high-permeation flux.
基金supported by the National Key Scientific Instrument and Equipment Development Project of China(No.21627809)the National Natural Science Foundation of China(No.21777056)+2 种基金the Natural Science Foundation of Shandong Province(China)(Nos.ZR2020MB091 and ZR2020MB037)the Youth Innovative Talents Recruitment and Cultivation Program of Shandong Higher Education(China)the Jinan Scientifie Research Leader Workshop Project(China)(No.2018GXRC021).
文摘Achieving hydrogen production and simultaneous decomposition of organic pollutants through dual-functional photocatalytic reactions has received increasing attention due to the environmentally friendly and cost-effective characteristics of this approach.In this work,an urchin-like oxygen-doped MoS_(2)/ZnIn_(2)S_(4)(OMS/ZIS)composite was fabricated for the first time using a simple solvothermal method.The unique microstructure with abundant active sites and fast charge transfer channels further shortened the charge migration distance and compressed carrier recombination.The obtained composite exhibited an efficient H2 evolution reaction rate of 12.8 mmol/g/h under visible light,which was nearly times higher than pristine ZnIn_(2)S_(4),and the apparent quantum efficiency was 14.9%(420 nm).The results of the simultaneous photocatalytic H2 evolution and organic pollutant decomposition test were satisfactory,resulting in decomposition efficiencies of resorcinol,tetracycline,and bisphenol A that reached 41.5%,63.5%,and 53.0%after 4 h,respectively,and the highest H2 evolution rate was 672.7 umol/g/h for bisphenol A.Furthermore,natural organic matter(NOM)abundantly found in actual water was adopted as an electron donor for H production under simulated sunlight irradiation,indicating the promising practicability of simultaneous hydrogen evolution and NOM decomposition.Moreover,the mechanisms of the dual-purpose photocatalytic reactions,as well as the synergistic effect between the molecular structures of the organic pollutants and the corresponding adsorption behavior on the photocatalyst surface were illustrated in detail.These obtained results may serve as an inspiration for the rational design of highly efficient,dual-functional photocatalysts in the future.
基金Supported by the National Natural Science Foundation of China(41505097)Basic Research and Operation Funds of Chinese Academy of Meteorological Sciences(2017Z004)
文摘Measuring the impacts of uncertainties identified from different global climate models(GCMs),representative concentration pathways(RCPs),and parameters of statistical crop models on the projected effects of climate change on crop yields can help to improve the availability of simulation results.The quantification and separation of different sources of uncertainty also help to improve understanding of impacts of uncertainties and provide a theoretical basis for their reduction.In this study,uncertainties of maize yield predictions are evaluated by using 30 sets of parameters from statistical crop models together with eight GCMs with reference to three emission scenarios for Jilin Province of northeastern China.Regression models using replicates based on bootstrap resampling reveal that yields are maximized when the optimum average growing season temperature is 20.1°C for 1990–2009.The results of multi-model ensemble simulations show a maize yield reduction of 11%,with 75%probability for 2040–69 relative to the baseline period of 1976–2005.We decompose the variance so as to understand the relative importance of different sources of uncertainty,such as GCMs,RCPs,and statistical model parameters.The greatest proportion of uncertainty(>50%)is derived from GCMs,followed by RCPs with a proportion of 28%and statistical crop model parameters with a proportion of 20%of total ensemble uncertainty.
基金supported by grants from the National Natural Science Foundation of China(No.81703032)Natural Science Foundation of Hubei Province(No.2019CFB501)CSCO-Hengrui Cancer Research Fund(Y-HR2018-342).
文摘Background:Aurora kinases(AURKs)family plays a vital role not only in cell division but also in tumorigenesis.However,there are still rare systematic analyses of the diverse expression patterns and prognostic value of the AURKs family in breast cancer(BC).Systematic bioinformatics analysis was conducted to explore the biological role,prognostic value,and immunologic function of AURKs family in BC.Methods:The expression,prognostic value,and clinical functions of AURKs family in BC were evaluated with several bioinformatics web portals:ONCOMINE Gene Expression Profiling Interactive Analysis,Kaplan-Meier plotter,cBioPortal,Metascape,GeneMANIA,and LinkedOmics;and the result was verified using human tissues.Results:The expression of AURKA and AURKB were upregulated in BC in subgroup analyses based on tumor stage(all P<0.05).BC patients with high AURKA and AURKB expression had a worse overall survival,relapse-free survival,and distant metastasisfree survival(all P<0.05).Verification experiment revealed that AURKA and AURKB were upregulated in BC(P<0.05).AURKA and AURKB were specifically associated with several tumor-associated kinases(polo-like kinase 1 and cyclin-dependent kinase 1),miRNAs(miR-507 and miR-381),and E2F transcription factor 1.Moreover,AURKA and AURKB were correlated with immune cell infiltration.Functional enrichment analysis revealed that AURKA and AURKB were involved in the cell cycle signaling pathway,platinum drug resistance signaling pathway,ErbB signaling pathway,Hippo signaling pathway,and nucleotide-binding and oligomerization domain-like receptor signaling pathway.Conclusions:Aurora kinases AURKA and AURKB could be employed as novel prognostic biomarkers or promising therapeutic targets for BC.
基金This work was supported by grants from the National Natural Science Foundation of China(Grant No.51978311)the Shandong Provincial Natural Science Foundation,China(No.ZR2019BEE044).
文摘Titanium-based coagulation has proved to be effective for algae-laden micro-polluted water purification processes.However,the influence of algae inclusion in surface water treatment by titanium coagulation is barely reported.This study reports the influence of both Microcystis aeruginosa and Microcystis wesenbergii in surface water during polytitanium coagulation.Jar tests were performed to evaluate coagulation performance using both algae-free(controlled)and algae-laden water samples,and floc properties were studied using a laser diffraction particle size analyzer for online monitoring.Results show that polytitanium coagulation can be highly effective in algae separation,removing up to 98%from surface water.Additionally,the presence of algae enhanced organic matter removal by up to 30%compared to controlled water containing only organic matter.Polytitanium coagulation achieved significant removal of fluorescent organic materials and organic matter with a wide range of molecular weight distribution(693–4945 Da)even in the presence of algae species in surface water.The presence of algae cells and/or algal organic matter is likely to function as an additional coagulant or flocculation aid,assisting polytitanium coagulation through adsorption and bridging effects.Although the dominant coagulation mechanisms with polytitanium coagulant were influenced by the coagulant dosage and initial solution pH,algae species in surface water could enhance the charge neutralization capability of the polytitanium coagulant.Algae-rich flocs were also more prone to breakage with strength factors approximately 10%lower than those of algae-free flocs.Loose structure of the flocs will require careful handling of the flocs during coagulation-sedimentation-filtration processes.
基金Acknowledgements We thank Xinqiang Zhang, Xinhua Zeng, and Xin Zhao for their assistance in the field survey and laboratory analysis. This work was funded jointly by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA05060600), the Natural Science Foundation of Hebei Province (No. C2015503008), and the Doctoral Initial Fund Project of Hebei Academy of Sciences (No. 20150503LR62-1). We would also like to thank Christine Verhille at the University of British Columbia for her assistance with the English language and grammatical editing of the manuscript.
文摘Most studies do not consider the potential variation in carbon concentration among the different tree components of the same species in regional scale. This study examined the carbon concentrations of the compo- nents (i.e., foliage, branch, stem, and root) in a 10-year-old poplar species (Populus davidiana Dode) from the Desertification Combating Program of Northern China. The highest and lowest carbon concentrations were found in the stem and foliage, respectively. There was a significant difference in carbon concentrations among the different tree components. All of the observed carbon concentrations of tree components were lower than those predicted using the conversion factor of 0.5 applied to component biomass. Stem carbon made up 59.7% of the total tree biomass carbon. The power equation estimating proportion of tree biomass carbon against the independent variable of diameter at breast height explained more than 90% of the variability in allocation of carbon among tree components. Tree height, as a second independent variable is also discussed. Our results suggest that the difference in organic carbon concentration among tree components should be incorporated into accurately develop forest carbon budget. Moreover, further investigations on how the diameter at breast height equation developed in the present study performs across broader scales are required.