In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippo-campi of APP/PS1 transgenic Alzheimer＇s disease model mice. Immunofluorescence staining revealed that the number of newly ge...In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippo-campi of APP/PS1 transgenic Alzheimer＇s disease model mice. Immunofluorescence staining revealed that the number of newly generated （BrdU＋） cells in the subgranular zone of the dentate gyrus in the hippocampus was signiifcantly higher in Alzheimer＇s disease mice after adipose-de-rived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU＋/DCX＋neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these ifndings, we propose that adipose-derived mes-enchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer＇s disease mice, thereby facilitating functional recovery.展开更多
Intercoronary communication is an uncommon congenital coronary variation.[1] There is a connection between two or more coronary arteries whose blood flow can be either unidirectional or bidirectional.[2] Therefore,thi...Intercoronary communication is an uncommon congenital coronary variation.[1] There is a connection between two or more coronary arteries whose blood flow can be either unidirectional or bidirectional.[2] Therefore,this anomalous intercoronary communications may be mistaken as a functional collateral vessel seen in the obstructive coronary artery disease (CAD). Coronary collateral vessels are usually related to severe coronary stenosis or total occlusions,while intercoronary communication is usually found in angiographically normal coronary arteries. Intercoronary communication differentiates coronary collateral vessels by angiographic features and histological structure.[3,4] The functional importance of intercoronary communication remains controversial.[1,3] We report two cases about this rare communication between left circumflex artery (LCx) and right coronary artery (RCA).展开更多
Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but incon...Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.展开更多
Laser-induced breakdown spectroscopy (LIBS) is an emerging analytical spectroscopy technique. This review presents the main recent developments in China regarding the implementation of LIBS for coal analysis. The pape...Laser-induced breakdown spectroscopy (LIBS) is an emerging analytical spectroscopy technique. This review presents the main recent developments in China regarding the implementation of LIBS for coal analysis. The paper mainly focuses on the progress of the past few years in the fundamentals, data pretreatment, calibration model, and experimental issues of LIBS and its application to coal analysis. Many important domestic studies focusing on coal quality analysis have been conducted. For example, a proposed novel hybrid quantification model can provide more reproducible quantitative analytical results; the model obtained the average absolute errors (AREs) of 0.42%, 0.05%, 0.07%, and 0.17% for carbon, hydrogen, volatiles, and ash, respectively, and a heat value of 0.07 MJ/kg. Atomic/ionic emission lines and molecular bands, such as CN and C-2, have been employed to generate more accurate analysis results, achieving an ARE of 0.26% and a 0.16% limit of detection (LOD) for the prediction of unburned carbon in fly ashes. Both laboratory and on-line LIBS apparatuses have been developed for field application in coal-fired power plants. We consider that both the accuracy and the repeatability of the elemental and proximate analysis of coal have increased significantly and further efforts will be devoted to realizing large-scale commercialization of coal quality analyzer in China.展开更多
基金supported by the National High-Tech Research and Development Program of China(863 Program),No.2012AA020905Tsinghua-Yue-Yuen Medical Sciences Fund,No.20240000514
文摘In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippo-campi of APP/PS1 transgenic Alzheimer＇s disease model mice. Immunofluorescence staining revealed that the number of newly generated （BrdU＋） cells in the subgranular zone of the dentate gyrus in the hippocampus was signiifcantly higher in Alzheimer＇s disease mice after adipose-de-rived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU＋/DCX＋neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these ifndings, we propose that adipose-derived mes-enchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer＇s disease mice, thereby facilitating functional recovery.
基金supported by grant from the National Natural Science Foundation of Hubei Province (No. 2017 CFB671)
文摘Intercoronary communication is an uncommon congenital coronary variation.[1] There is a connection between two or more coronary arteries whose blood flow can be either unidirectional or bidirectional.[2] Therefore,this anomalous intercoronary communications may be mistaken as a functional collateral vessel seen in the obstructive coronary artery disease (CAD). Coronary collateral vessels are usually related to severe coronary stenosis or total occlusions,while intercoronary communication is usually found in angiographically normal coronary arteries. Intercoronary communication differentiates coronary collateral vessels by angiographic features and histological structure.[3,4] The functional importance of intercoronary communication remains controversial.[1,3] We report two cases about this rare communication between left circumflex artery (LCx) and right coronary artery (RCA).
基金This study was supported by the National Natural Science Foundation of China(Nos.81671664 and 81621003)National Program for Support of Top-notch Young Professionals(No.W02070140)+3 种基金Fundamental Research Funds for the Central Universities(No.2018SCUH0011)Science and Technology Project of the Health Commission of Sichuan Province(No.18ZD035)Sichuan Science and Technology Program(No.2019YJ0155)1-3-5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC08001 and ZYJC18020).
文摘Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.
文摘Laser-induced breakdown spectroscopy (LIBS) is an emerging analytical spectroscopy technique. This review presents the main recent developments in China regarding the implementation of LIBS for coal analysis. The paper mainly focuses on the progress of the past few years in the fundamentals, data pretreatment, calibration model, and experimental issues of LIBS and its application to coal analysis. Many important domestic studies focusing on coal quality analysis have been conducted. For example, a proposed novel hybrid quantification model can provide more reproducible quantitative analytical results; the model obtained the average absolute errors (AREs) of 0.42%, 0.05%, 0.07%, and 0.17% for carbon, hydrogen, volatiles, and ash, respectively, and a heat value of 0.07 MJ/kg. Atomic/ionic emission lines and molecular bands, such as CN and C-2, have been employed to generate more accurate analysis results, achieving an ARE of 0.26% and a 0.16% limit of detection (LOD) for the prediction of unburned carbon in fly ashes. Both laboratory and on-line LIBS apparatuses have been developed for field application in coal-fired power plants. We consider that both the accuracy and the repeatability of the elemental and proximate analysis of coal have increased significantly and further efforts will be devoted to realizing large-scale commercialization of coal quality analyzer in China.
