背景抑郁焦虑情绪是孕产妇常见的心理问题,许多研究表明,孕产妇身体意象失调与抑郁焦虑情绪密切相关,但研究结论存在差异。目的对孕产妇身体意象失调与抑郁焦虑情绪关系的研究现状进行综述,为对孕产妇身体意象失调和抑郁焦虑情绪的干预...背景抑郁焦虑情绪是孕产妇常见的心理问题,许多研究表明,孕产妇身体意象失调与抑郁焦虑情绪密切相关,但研究结论存在差异。目的对孕产妇身体意象失调与抑郁焦虑情绪关系的研究现状进行综述,为对孕产妇身体意象失调和抑郁焦虑情绪的干预提供参考。方法于2023年1月10日,检索PubMed、Embase、CINAHL、Web of Science、中国知网、维普数据库、万方数据库和中国生物医学文献数据库,收集与孕产妇身体意象失调和抑郁焦虑情绪相关的研究,检索时限为建库至2023年1月1日。提取纳入文献的基本信息、身体意象失调的影响因素和研究结论等内容并汇总分析。结果共纳入文献14篇,孕产妇身体意象失调主要表现为对体重和体型恢复的担忧,受人口学特征、社会文化因素、产科相关因素等影响。孕产妇身体意象失调可预测抑郁情绪的发生,与焦虑情绪密切相关。结论身体意象失调严重影响孕产妇的生理和心理状态,可能进一步加重其抑郁焦虑情绪。展开更多
Background Accurate detection of human epidermal growth factor receptor 2 （HER2） expression and gene amplification is crucial for the application of HER2-specific therapy and for evaluating the response of patients ...Background Accurate detection of human epidermal growth factor receptor 2 （HER2） expression and gene amplification is crucial for the application of HER2-specific therapy and for evaluating the response of patients with breast cancer.A uniform and standard procedure of immunohistochemistry （IHC） and fluorescence in situ hybridization （FISH） needs to be established for evaluating the HER2 status in breast cancer tissues for the treatment of patients with real HER2-positive tumors.The present multicenter study was aimed to examine the HER2 status in breast cancer specimens from Chinese patients using both IHC and FISH methods.Methods A multicenter study was performed on the HER2 status in 3 149 breast cancer specimens from different ethnic populations and areas in China by IHC and FISH assays.The potential association of HER2 status with demographic and clinical characteristics was analyzed.Results The positive rates for HER2 over-expression and HER2 amplification were 23.3％ and 27.5％ in this study,respectively.The concordance between IHC and FISH was 71.2％ （K=0.494,P ＜0.001）.Furthermore,72.9％ of specimens with IHC 2＋ were negative to FISH.The discordance rates among laboratories were from 5％ to 28％ for IHC and 1％ to 16％ for FISH.HER2 amplification was associated significantly with advanced tumor stage （Ⅲ or Ⅳ,P=0.002）,large tumor size （＞5 cm,P=0.002）,moderate and poor histological grades （P ＜0.0001）,post-menopause （P ＜0.0001）,ER-PR-（P=0.002）,and having ＞4 lymph nodes affected （P ＜0.0001） in this population.The positive rates of HER2 amplification in specimens from Man and Hui Chinese were significantly higher than that in other Chinese populations.There are slightly higher positive rates of HER2 expression and amplification in Chinese patients with breast cancer.Conclusion These findings may provide new insights into understanding the epidemiological features of HER2 expression and amplification,and may be valuable for clinical practice.展开更多
文摘背景抑郁焦虑情绪是孕产妇常见的心理问题,许多研究表明,孕产妇身体意象失调与抑郁焦虑情绪密切相关,但研究结论存在差异。目的对孕产妇身体意象失调与抑郁焦虑情绪关系的研究现状进行综述,为对孕产妇身体意象失调和抑郁焦虑情绪的干预提供参考。方法于2023年1月10日,检索PubMed、Embase、CINAHL、Web of Science、中国知网、维普数据库、万方数据库和中国生物医学文献数据库,收集与孕产妇身体意象失调和抑郁焦虑情绪相关的研究,检索时限为建库至2023年1月1日。提取纳入文献的基本信息、身体意象失调的影响因素和研究结论等内容并汇总分析。结果共纳入文献14篇,孕产妇身体意象失调主要表现为对体重和体型恢复的担忧,受人口学特征、社会文化因素、产科相关因素等影响。孕产妇身体意象失调可预测抑郁情绪的发生,与焦虑情绪密切相关。结论身体意象失调严重影响孕产妇的生理和心理状态,可能进一步加重其抑郁焦虑情绪。
文摘Background Accurate detection of human epidermal growth factor receptor 2 （HER2） expression and gene amplification is crucial for the application of HER2-specific therapy and for evaluating the response of patients with breast cancer.A uniform and standard procedure of immunohistochemistry （IHC） and fluorescence in situ hybridization （FISH） needs to be established for evaluating the HER2 status in breast cancer tissues for the treatment of patients with real HER2-positive tumors.The present multicenter study was aimed to examine the HER2 status in breast cancer specimens from Chinese patients using both IHC and FISH methods.Methods A multicenter study was performed on the HER2 status in 3 149 breast cancer specimens from different ethnic populations and areas in China by IHC and FISH assays.The potential association of HER2 status with demographic and clinical characteristics was analyzed.Results The positive rates for HER2 over-expression and HER2 amplification were 23.3％ and 27.5％ in this study,respectively.The concordance between IHC and FISH was 71.2％ （K=0.494,P ＜0.001）.Furthermore,72.9％ of specimens with IHC 2＋ were negative to FISH.The discordance rates among laboratories were from 5％ to 28％ for IHC and 1％ to 16％ for FISH.HER2 amplification was associated significantly with advanced tumor stage （Ⅲ or Ⅳ,P=0.002）,large tumor size （＞5 cm,P=0.002）,moderate and poor histological grades （P ＜0.0001）,post-menopause （P ＜0.0001）,ER-PR-（P=0.002）,and having ＞4 lymph nodes affected （P ＜0.0001） in this population.The positive rates of HER2 amplification in specimens from Man and Hui Chinese were significantly higher than that in other Chinese populations.There are slightly higher positive rates of HER2 expression and amplification in Chinese patients with breast cancer.Conclusion These findings may provide new insights into understanding the epidemiological features of HER2 expression and amplification,and may be valuable for clinical practice.
