目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗...目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗的AECOPD患者191例,根据患者治疗意愿将其分为观察组(96例)和对照组(95例)。对照组患者接受常规西医治疗方案,观察组患者在此基础上口服本院中药痰浊阻肺协定方,疗程1周。比较两组患者的中医证候积分、慢性阻塞性肺病评估测试(COPD assessment test,CAT)、肺功能、实验室指标和疗效。结果 观察组患者的总有效率显著高于对照组(χ^(2)=4.573,P=0.030)。治疗后,两组患者的中医证候积分、CAT评分、超敏C反应蛋白(hypersensitive C-reaction protein,hsCRP)、白细胞介素-6(interleukin-6,IL-6)均显著低于本组治疗前,用力肺活量占预计值百分比(percentage of forced vital capacity to predicted value,FVC%)、第1秒用力呼气容积占预计值百分比(percentage of forced expiratory volume in one second to predicted value,FEV_(1)%)均显著高于本组治疗前(P<0.05);观察组患者的动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))低于本组治疗前,动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))高于本组治疗前(P<0.05);观察组患者的中医证候积分、CAT评分、hsCRP、IL-6均显著低于对照组,FVC%、FEV_(1)%、PaO_(2)均显著高于对照组(P<0.05)。结论 在西医治疗基础上辅以痰浊阻肺协定方可更有效改善AECOPD患者的临床症状,缓解体内炎症,有助于肺功能恢复,提高患者的生活质量。展开更多
Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery fa...Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.展开更多
文摘目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗的AECOPD患者191例,根据患者治疗意愿将其分为观察组(96例)和对照组(95例)。对照组患者接受常规西医治疗方案,观察组患者在此基础上口服本院中药痰浊阻肺协定方,疗程1周。比较两组患者的中医证候积分、慢性阻塞性肺病评估测试(COPD assessment test,CAT)、肺功能、实验室指标和疗效。结果 观察组患者的总有效率显著高于对照组(χ^(2)=4.573,P=0.030)。治疗后,两组患者的中医证候积分、CAT评分、超敏C反应蛋白(hypersensitive C-reaction protein,hsCRP)、白细胞介素-6(interleukin-6,IL-6)均显著低于本组治疗前,用力肺活量占预计值百分比(percentage of forced vital capacity to predicted value,FVC%)、第1秒用力呼气容积占预计值百分比(percentage of forced expiratory volume in one second to predicted value,FEV_(1)%)均显著高于本组治疗前(P<0.05);观察组患者的动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))低于本组治疗前,动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))高于本组治疗前(P<0.05);观察组患者的中医证候积分、CAT评分、hsCRP、IL-6均显著低于对照组,FVC%、FEV_(1)%、PaO_(2)均显著高于对照组(P<0.05)。结论 在西医治疗基础上辅以痰浊阻肺协定方可更有效改善AECOPD患者的临床症状,缓解体内炎症,有助于肺功能恢复,提高患者的生活质量。
基金supported by the National Key R&D Program of China(2022YFB2404300)the National Natural Science Foundation of China(NSFC Nos.52177217 and 52106244)。
文摘Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.
