Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,enviro...Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,environmental pollutants have caused great harm to public health.Phthalates,as a class of endocrine-disrupting chemicals(EDCs),are synthesized and used in large quantities as plasticizers due to their chemical properties.They are easily released into environment because of their noncovalent interactions with substances,causing human exposure and possibly impairing ovary.In recent years,more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases.And it is urgent to study the role of methylation,gene imprinting,miRNA,and other epigenetic mechanisms in reproductive toxicology.展开更多
Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness optimization.The synchrotron radiation will suppress the oscillation and make the detection u...Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness optimization.The synchrotron radiation will suppress the oscillation and make the detection unusual difficulty without any kicker excitation.Purpose A new high sensitivity tune measurement system is developed to show the real-time tune during the colliding.Method Peak diode detectors are used to convert short beam pulses from a button BPM into slowly varying signals.Their DC components,constituting a large background related to beam offsets,are suppressed by series capacitors,while the small signals related to beam oscillations are passed to the subsequent stages for amplification and filtering.Conclusion A direct diode detection technique based on the diode peak hold circuit could increase the sensitivity by hundreds time which gets a clearly tune peak even with synchrotron radiation and bunch-by-bunch feedback damping.展开更多
基金supported by the National Natural Science Foundation of China(No.81571508 and No.81771654)the National Natural Science Youth Foundation of China(No.81701520)the Self-dependent Innovation Research Funding of Huazhong University of Science and Technology(No.2017KFYXJJ121)。
文摘Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,environmental pollutants have caused great harm to public health.Phthalates,as a class of endocrine-disrupting chemicals(EDCs),are synthesized and used in large quantities as plasticizers due to their chemical properties.They are easily released into environment because of their noncovalent interactions with substances,causing human exposure and possibly impairing ovary.In recent years,more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases.And it is urgent to study the role of methylation,gene imprinting,miRNA,and other epigenetic mechanisms in reproductive toxicology.
基金Funding This work was funded by the Youth Innovation Promotion Association CAS(No.2019013 and Y202005)the National Natural Science Foundation of China(No.11975254).
文摘Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness optimization.The synchrotron radiation will suppress the oscillation and make the detection unusual difficulty without any kicker excitation.Purpose A new high sensitivity tune measurement system is developed to show the real-time tune during the colliding.Method Peak diode detectors are used to convert short beam pulses from a button BPM into slowly varying signals.Their DC components,constituting a large background related to beam offsets,are suppressed by series capacitors,while the small signals related to beam oscillations are passed to the subsequent stages for amplification and filtering.Conclusion A direct diode detection technique based on the diode peak hold circuit could increase the sensitivity by hundreds time which gets a clearly tune peak even with synchrotron radiation and bunch-by-bunch feedback damping.
