Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quant...Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quantum information,quantum threshold signatures are gradually becoming more popular.Recently,a quantum(t,n)threshold group signature scheme was analyzed that uses techniques such as quantum-controlled-not operation and quantum teleportation.However,this scheme cannot resist forgery attack and does not conform to the design of a threshold signature in the signing phase.Based on the original scheme,we propose an improved quantum(t,n)threshold signature scheme using quantum(t,n)threshold secret sharing technology.The analysis proves that the improved scheme can resist forgery attack and collusion attack,and it is undeniable.At the same time,this scheme reduces the level of trust in the arbitrator during the signature phase.展开更多
Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the pre...Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the prevention of childhood AL.Methods:Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened.Subgroup meta-analysis was conducted according to the type of leukemia.Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity.Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software;Funnel plots were applied to conduct bias analysis for those included literatures.Results:Ten related literatures were included after data screening,4593 cases in AL group and 6157 cases in control group respectively.According to heterogeneity test result(χ2 = 16.26,P < 0.05),the combined OR values and 95% CI were calculated with random effects model,which were 1.02(0.92-1.14),Z = 0.41,P = 0.68 > 0.05,indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia(AL).Subgroup analysis:for the association between maternal alcohol consumption during pregnancy and childhood acute lymphoblastic leukemia(ALL),the combined OR value and 95% CI were 0.92(0.84-1.00),Z = 1.92,P = 0.05,indicating that there was significant difference between two groups;for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia(ANLL),the combined OR values and 95% CI were 0.82(0.61-1.11),Z = 1.30,P = 0.19 > 0.05,indicating that there was no significant difference between two groups.Conclusion:Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL,but not in childhood ANLL.展开更多
Leucine-rich repeat containing G protein-coupled receptor 5(Lgr5), a marker of intestinal stem cells(ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However...Leucine-rich repeat containing G protein-coupled receptor 5(Lgr5), a marker of intestinal stem cells(ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However, the activation of Lgr5 by integrated signaling pathways upon radiation remains poorly understood. Here, we show that irradiation of mice with whole-body depletion or conditional ablation of REGγ in Lgr5^(+) stem cell impairs proliferation of intestinal crypts, delaying regeneration of intestine epithelial cells. Mechanistically, REGγ enhances transcriptional activation of Lgr5 via the potentiation of both Wnt and Hippo signal pathways. TEAD4 alone or cooperates with TCF4, a transcription factor mediating Wnt signaling, to enhance the expression of Lgr5. Silencing TEAD4 drastically attenuated β-catenin/TCF4 dependent expression of Lgr5. Together, our study reveals how REGγ controls Lgr5 expression and expansion of Lgr5+stem cells in the regeneration of intestinal epithelial cells.Thus, REGγ proteasome appears to be a potential therapeutic target for radiation-induced gastrointestinal disorders.展开更多
基金the National Natural Science Foundation of China(Grant Nos.61771294 and 61972235)。
文摘Threshold signature is an important branch of the digital signature scheme,which can distribute signature rights and avoid the abuse of signature rights.With the continuous development of quantum computation and quantum information,quantum threshold signatures are gradually becoming more popular.Recently,a quantum(t,n)threshold group signature scheme was analyzed that uses techniques such as quantum-controlled-not operation and quantum teleportation.However,this scheme cannot resist forgery attack and does not conform to the design of a threshold signature in the signing phase.Based on the original scheme,we propose an improved quantum(t,n)threshold signature scheme using quantum(t,n)threshold secret sharing technology.The analysis proves that the improved scheme can resist forgery attack and collusion attack,and it is undeniable.At the same time,this scheme reduces the level of trust in the arbitrator during the signature phase.
文摘Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the prevention of childhood AL.Methods:Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened.Subgroup meta-analysis was conducted according to the type of leukemia.Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity.Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software;Funnel plots were applied to conduct bias analysis for those included literatures.Results:Ten related literatures were included after data screening,4593 cases in AL group and 6157 cases in control group respectively.According to heterogeneity test result(χ2 = 16.26,P < 0.05),the combined OR values and 95% CI were calculated with random effects model,which were 1.02(0.92-1.14),Z = 0.41,P = 0.68 > 0.05,indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia(AL).Subgroup analysis:for the association between maternal alcohol consumption during pregnancy and childhood acute lymphoblastic leukemia(ALL),the combined OR value and 95% CI were 0.92(0.84-1.00),Z = 1.92,P = 0.05,indicating that there was significant difference between two groups;for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia(ANLL),the combined OR values and 95% CI were 0.82(0.61-1.11),Z = 1.30,P = 0.19 > 0.05,indicating that there was no significant difference between two groups.Conclusion:Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL,but not in childhood ANLL.
基金supported by the National Natural Science Foundation of China (82073483, 31730017, 82022051)the Science and Technology Commission of Shanghai Municipality (19JC1411900, 20s11901500)Changning Maternity and Infant Health Hospital PI team building project (311-20031)。
文摘Leucine-rich repeat containing G protein-coupled receptor 5(Lgr5), a marker of intestinal stem cells(ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However, the activation of Lgr5 by integrated signaling pathways upon radiation remains poorly understood. Here, we show that irradiation of mice with whole-body depletion or conditional ablation of REGγ in Lgr5^(+) stem cell impairs proliferation of intestinal crypts, delaying regeneration of intestine epithelial cells. Mechanistically, REGγ enhances transcriptional activation of Lgr5 via the potentiation of both Wnt and Hippo signal pathways. TEAD4 alone or cooperates with TCF4, a transcription factor mediating Wnt signaling, to enhance the expression of Lgr5. Silencing TEAD4 drastically attenuated β-catenin/TCF4 dependent expression of Lgr5. Together, our study reveals how REGγ controls Lgr5 expression and expansion of Lgr5+stem cells in the regeneration of intestinal epithelial cells.Thus, REGγ proteasome appears to be a potential therapeutic target for radiation-induced gastrointestinal disorders.
