A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerate...A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerated,providing a mild and simple method for the synthesis of C2-hydroxyalkylated2 H-benzothiazoles in moderate to good yields.Besides,ethers were also compatible in this reaction,leading to corresponding C2 ether-substituted 2 H-benzothiazoles with high regioselectivity.展开更多
基金the financial support by the National Natural Science Foundation of China(No.30900959)the Natural Science Foundation of Zhejiang Province(No.LY17C140003)。
文摘A visible-light induced metal-free approach was described for the hydroxyalkylation of 2 Hbenzothiazoles with alcohols by using selectfluor as the oxidant.A variety of 2 H-benzothiazoles and alcohols could be tolerated,providing a mild and simple method for the synthesis of C2-hydroxyalkylated2 H-benzothiazoles in moderate to good yields.Besides,ethers were also compatible in this reaction,leading to corresponding C2 ether-substituted 2 H-benzothiazoles with high regioselectivity.
