Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological assaults.To protect the epithelial tissues and maintain their homeostasis,multiple layers of...Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological assaults.To protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are required.Besides the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to challenges.Chemokines and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune cells.Among them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity.CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues.CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus.Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response.On the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites.Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune surveillance.Herein,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation.展开更多
In this work,an onion-like carbon(OLC)nanoparticle coating with a micron-sized thickness was fabricated via aerosol deposition(AD).During the room temperature impact consolidation(RTIC),the OLC nanoparticles(5-10 nm)e...In this work,an onion-like carbon(OLC)nanoparticle coating with a micron-sized thickness was fabricated via aerosol deposition(AD).During the room temperature impact consolidation(RTIC),the OLC nanoparticles(5-10 nm)experienced remarkable deformation along both the perpendicular and parallel directions to the coating-substiate interface.Particle deformation,mechanical interlocking,and van der Waals forces between the OLC particles were revealed as the major regimes for coating formation.The aerosol deposition technique might open new avenues for fabricating carbonaceous nanostructures for various functional applications.展开更多
文摘Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological assaults.To protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are required.Besides the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to challenges.Chemokines and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune cells.Among them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity.CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues.CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus.Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response.On the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites.Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune surveillance.Herein,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation.
基金the National Natural Science Foundation of China(grant#41476064 and 31500772)Zhejiang Provincial Natural Science Foundation of China(LY18C100003).
文摘In this work,an onion-like carbon(OLC)nanoparticle coating with a micron-sized thickness was fabricated via aerosol deposition(AD).During the room temperature impact consolidation(RTIC),the OLC nanoparticles(5-10 nm)experienced remarkable deformation along both the perpendicular and parallel directions to the coating-substiate interface.Particle deformation,mechanical interlocking,and van der Waals forces between the OLC particles were revealed as the major regimes for coating formation.The aerosol deposition technique might open new avenues for fabricating carbonaceous nanostructures for various functional applications.
