Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor （GEF） that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases （Welch et al., 2002）. We previously rep...Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor （GEF） that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases （Welch et al., 2002）. We previously reported that aberrantly upreg- ulated P-Rex1 promotes prostate cancer metastasis by activating Racl signals （Qin et al., 2009）.展开更多
文摘Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor （GEF） that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases （Welch et al., 2002）. We previously reported that aberrantly upreg- ulated P-Rex1 promotes prostate cancer metastasis by activating Racl signals （Qin et al., 2009）.
