Conjugate addition‐enantioselective protonation to forge tertiary stereocentresαto azaarenes via cooperative hydrogen atom transfer and chiral hydrogen‐bonding catalysis

Cooperative hydrogen atom transfer and chiral hydrogen‐bonding catalysis as a new platform for the asymmetric synthesis of azaarene derivatives is reported.By using a tetrabutylammonium decatungstate as the photocatalyst and a chiral phosphoric acid as the hydrogen‐bonding catalyst,transformations of a variety of commercially available hydrocarbons and silanes with diverseα‐branched 2‐vinylazaarenes could efficiently experience a tandem radical conjugate addition and enantioselective protonation process,providing a convenient and fully atom economical approach to access a range of valuable enantioenrichedα‐tertiary azaarenes in high yields with good to excellent enantioselectivities(up to 93%ee).Through the direct use of tert‐butyl methylcarbamate as the feedstock,this method enables a highly practical and concise synthesis of the enantiomerically pure medicinal molecule pheniramine(Avil).

趋化因子及其受体在扁平苔藓发病机制中的研究进展

扁平苔藓是一种慢性皮肤黏膜炎症性疾病,也是界面性皮炎的代表性疾病,常累及皮肤、甲、毛发和黏膜,其发病机制尚不清楚,涉及诸多细胞因子及免疫分子。趋化因子是一大类具有趋化炎性细胞定向迁移的细胞因子,研究表明多种趋化因子参与了扁平苔藓的发病,文章就与扁平苔藓相关的趋化因子及其受体作一综述,探讨它们在扁平苔藓发病机制中的作用。