Currently,many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female reproduction.Since 2017,China's birth rate has hit historic lows and continu...Currently,many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female reproduction.Since 2017,China's birth rate has hit historic lows and continued to decline,with the death rate now equaling the birth rate.Concerns have emerged regarding the potential impact of environmental contaminants on reproductive health,including pregnancy loss.Endocrine-disrupting chemicals(EDCs)like phthalate esters(PAEs),bisphenol A(BPA),triclosan(TCS),and perfluoroalkyl substances(PFASs)have raised attention due to their adverse effects on biological systems.While China's 14th Five-Year Plan(2021–2025)for national economic and social development included the treatment of emerging pollutants,including EDCs,there are currently no national appraisal standards or regulatory frameworks for EDCs and their mixtures.Addressing the risk of EDC mixtures is an urgent matter that needs consideration from China's perspective in the near future.In this Perspective,we delve into the link between EDC mixture exposure and pregnancy loss in China.Our focus areas include establishing a comprehensive national plan targeting reproductive-aged women across diverse urban and rural areas,understanding common EDC combinations in women and their surrounding environment,exploring the relationship between EDCs and pregnancy loss via epidemiology,and reconsidering the safety of EDCs,particularly in mixtures and low-dose scenarios.We envision that this study could aid in creating preventive strategies and interventions to alleviate potential risks induced by EDC exposure during pregnancy in China.展开更多
Background:Parkinson’s disease(PD)is a common heterogeneous neurodegenerative disorder in elder population.Parkinson’s disease dementia(PDD)is one of the most common non-motor manifestations in PD patients.No compre...Background:Parkinson’s disease(PD)is a common heterogeneous neurodegenerative disorder in elder population.Parkinson’s disease dementia(PDD)is one of the most common non-motor manifestations in PD patients.No comprehensive review has been conducted to assess risk factors for PDD.Methods:A systemic search for studies on PDD risk factors was performed.Cohort and case–control studies that clearly defined PDD and presented relevant data were included.The data were analyzed to generate a pooled effect size and 95%confidence interval(CI).Publication bias was assessed using the Egger’s test and the Begg’s test.Results:A systematic search was conducted and yielded 5195 articles.After screening,25 studies were included in the current analysis.Development of PDD was positively associated with age(odds ratio[OR]1.07,95% CI 1.03-1.13),male(OR 1.33,95% CI 1.08-1.64),higher Unified Parkinson’s Disease Rating Scale(UPDRS)part III scores(relative risk[RR]1.04,95% CI 1.01-1.07),hallucination(OR 2.47,95% CI 1.36-4.47),REM sleep behavior disorder(RBD)(OR 8.38,95% CI 3.87-18.08),smoking(ever vs.never)(RR 1.93,95% CI 1.15-3.26)and hypertension(OR 1.57,95% CI 1.11-2.22).An inverse association was found between education(RR 0.94,95% CI 0.91-0.98)and PDD.Other reported factors,including age of onset,disease duration of PD,Hoehn and Yahr stage and diabetes mellitus were not significantly associated with PDD.Conclusions:Advanced age,male,higher UPDRS III scores,hallucination,RBD,smoking and hypertension increase the risk of PDD,whereas higher education is a protective factor for PDD.展开更多
To the Editor,Recent studies reported that lncRNA MIR205HG expression is associated with sensitivity to anti-epidermal growth factor receptor(EGFR)drug in lung cancer cells.However,few clinical studies reported the ro...To the Editor,Recent studies reported that lncRNA MIR205HG expression is associated with sensitivity to anti-epidermal growth factor receptor(EGFR)drug in lung cancer cells.However,few clinical studies reported the role of this molecule in breast cancer,particularly in the neoadjuvant setting.In this study,we explored the clinical significance of MIR205HG expression with its predictive and prognostic value for patients with locally advanced breast cancer.展开更多
基金supported by the National Key Research and Development Program of China(2023YFC3706600)the National Natural Science Foundation of China(22225605)the K.C.Wong Education Foundation of China(GJTD-2020-03).
文摘Currently,many countries and regions worldwide face the challenge of declining population growth due to persistently low rates of female reproduction.Since 2017,China's birth rate has hit historic lows and continued to decline,with the death rate now equaling the birth rate.Concerns have emerged regarding the potential impact of environmental contaminants on reproductive health,including pregnancy loss.Endocrine-disrupting chemicals(EDCs)like phthalate esters(PAEs),bisphenol A(BPA),triclosan(TCS),and perfluoroalkyl substances(PFASs)have raised attention due to their adverse effects on biological systems.While China's 14th Five-Year Plan(2021–2025)for national economic and social development included the treatment of emerging pollutants,including EDCs,there are currently no national appraisal standards or regulatory frameworks for EDCs and their mixtures.Addressing the risk of EDC mixtures is an urgent matter that needs consideration from China's perspective in the near future.In this Perspective,we delve into the link between EDC mixture exposure and pregnancy loss in China.Our focus areas include establishing a comprehensive national plan targeting reproductive-aged women across diverse urban and rural areas,understanding common EDC combinations in women and their surrounding environment,exploring the relationship between EDCs and pregnancy loss via epidemiology,and reconsidering the safety of EDCs,particularly in mixtures and low-dose scenarios.We envision that this study could aid in creating preventive strategies and interventions to alleviate potential risks induced by EDC exposure during pregnancy in China.
文摘Background:Parkinson’s disease(PD)is a common heterogeneous neurodegenerative disorder in elder population.Parkinson’s disease dementia(PDD)is one of the most common non-motor manifestations in PD patients.No comprehensive review has been conducted to assess risk factors for PDD.Methods:A systemic search for studies on PDD risk factors was performed.Cohort and case–control studies that clearly defined PDD and presented relevant data were included.The data were analyzed to generate a pooled effect size and 95%confidence interval(CI).Publication bias was assessed using the Egger’s test and the Begg’s test.Results:A systematic search was conducted and yielded 5195 articles.After screening,25 studies were included in the current analysis.Development of PDD was positively associated with age(odds ratio[OR]1.07,95% CI 1.03-1.13),male(OR 1.33,95% CI 1.08-1.64),higher Unified Parkinson’s Disease Rating Scale(UPDRS)part III scores(relative risk[RR]1.04,95% CI 1.01-1.07),hallucination(OR 2.47,95% CI 1.36-4.47),REM sleep behavior disorder(RBD)(OR 8.38,95% CI 3.87-18.08),smoking(ever vs.never)(RR 1.93,95% CI 1.15-3.26)and hypertension(OR 1.57,95% CI 1.11-2.22).An inverse association was found between education(RR 0.94,95% CI 0.91-0.98)and PDD.Other reported factors,including age of onset,disease duration of PD,Hoehn and Yahr stage and diabetes mellitus were not significantly associated with PDD.Conclusions:Advanced age,male,higher UPDRS III scores,hallucination,RBD,smoking and hypertension increase the risk of PDD,whereas higher education is a protective factor for PDD.
基金The authors disclosed receipt of the following financial support for the research,authorship,and/or publication of this article:This work was supported by Shanghai Natural Science Foundation(No.19ZR1431100)Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2020CR3003A,16CR3065B,12016231)+6 种基金Shanghai“Rising Stars of Medical Talent”Youth Development Program for Youth Medical Talents-Specialist Program(No.2018-15)Shanghai“Rising Stars of Medical Talent”Youth Development Program for Outstanding Youth Medical Talents(No.2018-16)Shanghai Collaborative Innovation Center for Translational Medicine(No.TM201908)Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University(No.YG2017QN49,ZH2018QNA42,YG2019QNA28)Nurturing Fund of Renji Hospital(No.PYMDT-002,PY2018-IIC-01,PY2018-III-15,PYIII20-09)Science and Technology Commission of Shanghai Municipality(No.20DZ2201600,15JC1402700)Shanghai Municipal Key Clinical Specialty.
文摘To the Editor,Recent studies reported that lncRNA MIR205HG expression is associated with sensitivity to anti-epidermal growth factor receptor(EGFR)drug in lung cancer cells.However,few clinical studies reported the role of this molecule in breast cancer,particularly in the neoadjuvant setting.In this study,we explored the clinical significance of MIR205HG expression with its predictive and prognostic value for patients with locally advanced breast cancer.
