Aquaporin 5 Expression and Its Relationship to Apoptosis in Different Grades of Differentiated Non-Small Cell Lung Carcinoma

Aquaporin 5 has been recently found as an important oncogenic marker whose expression levels seem to be determined by the level of cellular differentiation. Despite aquaporin volume decrease (AVD) being the most conserved earliest event in apoptosis, there is still a paucity of studies exploring on aquaporin expression and its relationship with apoptosis in cancer. The aim of this study was to investigate the expression of aquaporin 5 channel protein and to explore on its relationship with apoptosis in well and poorly differentiated non-small cell lung carcinoma both in-vivo and in-vitro. Findings from the study showed that the expression of AQP5 both in-vivo and in-vitro was dependent on the type and degree of tumour differentiation. In-vivo, an increase in aquaporin 5 expression was associated with an increased apoptosis in both poorly and highly differentiated adenocarcinoma (AC) while there was no association between aquaporin 5 expression and apoptosis in both poorly and highly differentiated squamous cell carcinoma (SCC). In vitro, differentiation therapy in the form of ATRA decreased both cell proliferation and increased the expression of AQP5 in A549 cells. The cytomorphological changes, expression of differentiation markers and flow cytometry apoptotic results were dependent on the dose of ATRA treatment. In conclusion, a higher expression of aquaporin 5 was found to promote the rate of the apoptotic process in lung adenocarcinoma (AC).

The Role of Anatomical Specimens in the Teaching of Anatomy

characteristics,complex content,and it is difficult to understand.In view of the nature of the subject,many different models and specimens are required during teaching,increasing the difficulty of its teaching.Although the mode of medical teaching is constantly updating,anatomical specimens are still important in the teaching of anatomy,as they help students to understand the organs,their positions,and structural forms as well as to better grasp the theoretical aspect.In addition,anatomical specimens and medical students contact condition can affect the teaching effect.Therefore,it is imperative to give full play to the role of anatomical specimens in anatomy teaching to improve the teaching effect.This paper summarizes the research on the use of anatomical specimens in the teaching of anatomy.

A dynamic speed guidance method at on-ramp merging areas of urban expressway considering driving styles

Dynamic speed guidance for vehicles in on-ramp merging zones is instrumental in alleviating traffic congestion on urban expressways.To enhance compliance with recommended speeds,the development of a dynamic speed-guidance mechanism that accounts for heterogeneity in human driving styles is pivotal.Utilizing intelligent connected technologies that provide real-time vehicular data in these merging locales,this study proposes such a guidance system.Initially,we integrate a multi-agent consensus algorithm into a multi-vehicle framework operating on both the mainline and the ramp,thereby facilitating harmonized speed and spacing strategies.Subsequently,we conduct an analysis of the behavioral traits inherent to drivers of varied styles to refine speed planning in a more efficient and reliable manner.Lastly,we investigate a closed-loop feedback approach for speed guidance that incorporates the driver’s execution rate,thereby enabling dynamic recalibration of advised speeds and ensuring fluid vehicular integration into the mainline.Empirical results substantiate that a dynamic speed guidance system incorporating driving styles offers effective support for human drivers in seamless mainline merging.