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Oral esomeprazole vs injectable omeprazole for the prevention of hemorrhage after endoscopic submucosal dissection 被引量:8
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作者 Takashi Uchiyama Takuma Higurashi +3 位作者 Hitoshi Kuriyama Yoshinobu Kondo yasuo hata Atsushi Nakajima 《World Journal of Gastrointestinal Endoscopy》 CAS 2017年第10期514-520,共7页
AIM To evaluate the effectiveness of oral esomeprazole(EPZ) vs injectable omeprazole(OPZ) therapy to prevent hemorrhage after endoscopic submucosal dissection(ESD).METHODS A case-control study was conducted using a qu... AIM To evaluate the effectiveness of oral esomeprazole(EPZ) vs injectable omeprazole(OPZ) therapy to prevent hemorrhage after endoscopic submucosal dissection(ESD).METHODS A case-control study was conducted using a quasirandomized analysis with propensity score matching. A total of 258 patients were enrolled in this study. Patients were treated with either oral EPZ or injectable OPZ. The endpoint was the incidence of hemorrhage after ESD.RESULTS Data of 71 subjects treated with oral EPZ and 172 subjects treated with injectable OPZ were analyzed. Analysis of 65 matched samples revealed no difference in the incidence of hemorrhage after ESD between the oral EPZ and injectable OPZ groups(OR = 0.89, 95%CI:0.35-2.27, P ≥ 0.99).CONCLUSION We conclude that oral EPZ therapy is a useful alternative to injectable PPI therapy for the prevention of hemorrhage after ESD. 展开更多
关键词 Endoscopic submucosal dissection Proton pump inhibitors HEMORRHAGE
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