基于内聚力单元法的船舶与重叠冰碰撞数值模拟研究

The gradual increase in shipping and drilling activities in the Arctic regions has resulted in the increased importance of studying the structural safety of polar ships in various ice conditions.Rafted ice refers to a type of accumulated and overlapped sea ice;it is driven by external forces,such as wind and waves,and may exert high loads on ships and threaten their structural safety.Therefore,the properties of rafted ice and the construction of numerical models should be studied before exploring the interaction and collision between ships and rafted ice.Based on the nonlinear finite-element method,this paper introduces the cohesive element model for the simulation of rafted ice.The interaction between ships and rafted ice is studied,and the ice force of the hull is obtained.Numerical simulation results are compared with model test findings,and the effectiveness of the cohesive element method in the construction of the model of rafted ice materials is verified.On this basis,a multilayer rafted ice model is constructed,and its interaction with the ship is studied.The research unveils that rafted ice parts impede crack generation and slow down crack propagation to a certain extent.

Combination of transarterial radioembolization with atezolizumab and bevacizumab for intermediate and advanced staged hepatocellular carcinoma:A preliminary report of safety and feasibility

Purpose:The IMbrave150 PhaseⅢtrial demonstrated superiority of atezolizumab and bevacizumab(Atezo/Bev)over sorafenib for unresectable hepatocellular carcinoma(HCC).The present study aims to evaluate the feasibility of TARE in combination with Atezo/Bev for treatment of intermediate and advanced staged HCC.Methods:Retrospective review at a single institution was performed between May 2021 and December 2022.Patients who received TARE using yttrium-90(Y90)with concomitant or sequential Atezo/Bev systemic treatment were included.The following outcomes were retrieved:overall survival(OS),radiologic tumor response,progression-free survival,technical adverse events related to TARE,and toxicity based on the National Cancer Institute–Common Terminology Criteria for Adverse Events version 5.0.Results:Ten consecutive patients with intermediate(n=4)and advanced stage HCC(n=6)were treated with TARE and sequential/concomitant Atezo/Bev.Tumor control was achieved in all TARE-treated target lesions(100%).Overall disease progression occurred in 4 patients with PFS of 78.8%and 66.7%at 6-and 12-months,respectively.Two patients died at follow-up,with 6-month and 12-month OS rates of 90.0%and 77.1%,respectively.Three(75%)patients with intermediate stage disease were downstaged into Milan criteria.One patient developed grade 3 transaminitis and hypoglobulinemia,while Atezo/Bev was switched to Lenvatinib in another patient due to immunotherapy related myositis.Conclusion:This study demonstrates initial safety and feasibility of combined TARE with Atezo/Bev for intermediate/advanced stage HCC.Further prospective studies with larger sample size are warranted.

Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China

Objective： The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer. Methods： The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics （FIGO） Ib-[Ia cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed. The median follow-up was 70 months. Results： Of all the patients, 61.6% of the cases received adjuvant therapy, with 5-year disease-free survival （DFS） of 92.1% and 5-year overall survival （OS） of 95.0%. In multivariate analysis, differentiation of G3 （P〈0.05）, lymph node metastasis （LNM, P〈0.05） and lymphovascular space invasion （LVSI, P〈0.05） were independent predictors for OS, while LNM （P〈0.05）, deep stroma invasion （DSI, P〈0.05） and LVSI （P〈0.05） were independent factors for DFS. The samples were stratified by histologic type, and cervical squamous cell carcinoma （SCC） was found to share the same independent factors except for differentiation of OS. As to patients with cervical adenocarcinoma/adenosquamons carcinoma （AC/ASC）, differentiation was the independent predictor of OS （P〈0.05）; and LVSI of DFS （P〈0.05）. Of 236 patients with high-risk factors, there was no significant difference in survival between concurrent chemoradiotherapy （CCRT, n=195）, radiotherapy （RT, n=24）, and chemotherapy （CT, n=17）. Among the 190 patients with LNM who underwent CCRT, 124 cases showed improved DFS after sequential CT （P=0.118）, with a recurrence rate decrease of 14%, though the difference was not statistically significant. Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy, but the difference was not statistically significant. Conclusions： LNM, LVSI, DSI and differentiation were found to be independent prognostic factors for operable cervical cancer. Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival. CCRT＋CT outperformed CCRT in high-risk patients. For patients with single non-high-risk factor, the role of adjuvant therapy needs to be further discussed.

Separate lateral parametrial lymph node dissection improves detection rate of parametrial lymph node metastasis in early-stage cervical cancer: 10-year clinical evaluation in a single center in China

Objective: To investigate the clinical significance of separate lateral parametrial lymph node dissection(LPLND) in improving parametrial lymph node(PLN) and its metastasis detection rate during radical hysterectomy for early-stage cervical cancer.Methods: From July 2007 to August 2017, 2,695 patients with cervical cancer in stage IB1-IIA2 underwent radical hysterectomy were included. Of these patients, 368 underwent separate dissection of PLNs using the LPLND method, and 2,327 patients underwent conventional radical hysterectomy(CRH). We compared the surgical parameters, PLN detection rate and PLN metastasis rate between the two groups.Results: Compared with CRH group, the rate of laparoscopic surgery was higher(60.3% vs. 15.9%, P<0.001),and the blood transfusion rate was lower(19.0% vs. 29.0%, P<0.001) in the LPLND group. PLNs were detected in 356 cases(96.7%) in the LPLND group, and 270 cases(11.6%) in the CRH group(P<0.001), respectively. The number of PLNs detected in the LPLND group was higher than that in the CRH group(median 3 vs. 1, P<0.001).The PLN metastases were detected in 25 cases(6.8%) in the LPLND group, and 18 cases(0.8%) in the CRH group(P<0.001), respectively. In multivariable analysis, LPLND is an independent factor not only for PLN detection [odds ratio(OR)=228.999, 95% confidence interval(95% CI): 124.661-420.664;P<0.001], but also for PLN metastasis identification(OR=10.867, 95% CI: 5.381-21.946;P<0.001).Conclusions: LPLND is feasible and safe. The surgical method significantly improves the detection rate of PLN and avoids omission of PLN metastasis during radical hysterectomy for early-stage cervical cancer.

Decorating Ag/AgCl on UiO-66-NH2: Synergy between Ag plasmons and heterostructure for the realization of efficient visible light photocatalysis

UiO-66-NH2, as typical visible light responsive Zr-based metal-organic frameworks (MOFs), has attracted great interest in recent years. However, rapid combination of the photoinduced carriers limits its further application. Here, we designed a facile precipitation-photoreduction method to post-synthetically decorate Ag/AgCl on the surface of UiO-66-NH2 and form a heterostructure. Metallic Ag can not only transmit electrons between UiO-66-NH2 and AgCl but also absorb visible light, because of the surface plasmon resonance (SPR) effect. The rhodamine B photodegradation rate of UiO-66-NH2/Ag/AgCl (16.2 wt.% Ag) is about 10 and 4 times those of UiO-66-NH2 and Ag/AgCl, respectively. The SPR effect of Ag NPs and the formation of a heterostructure synergistically increase the absorbability of visible light, accelerate the separation of photoinduced charges, and promote the formation of superoxide radicals. We expect that our work could provide a new viewpoint for constructing efficient MOF-based photocatalytic systems.

Limited energy parametrial resection/dissection during modified laparoscopic nerve-sparing radical hysterectomy

Objective: The aim of this study was to investigate the feasibility of using ultrasonic scalpel combined with vascular clip in parametrial management,called limited energy parametrial resection/dissection(LEPRD),in laparoscopic nerve plane-sparing radical hysterectomy(NPSRH),a modified nerve-sparing radical hysterectomy(NSRH); and to evaluate its effectiveness in pelvic autonomic nerve preservation.Methods: From July 2012 to January 2016,257 consecutive patients with stage IB1 to IIA2 cervical cancer who underwent NPSRH were included in this study.Patients were divided into three cohorts according to the different parametrial resection modality.The clinical,pathological and surgery-related parameters were compared between the three groups.Short-and long-term postoperative bladder functions were evaluated.Results: LEPRD was attempted in 94 patients,and was successful in 65(69.1%) patients(LEPRD group).The remaining 29(30.9%) patients required bipolar coagulation after failure of vascular clipping(combined modality group).Routine bipolar cautery was used in the other 163 patients during the parametrial resection(bipolar group).The blood loss in the LEPRD group was significantly lower than those in the other two groups(P<0.001).The rate of successful Foley removal on postoperative day 7 was significantly higher in the LEPRD group than in the bipolar group(P=0.022).The incidence of chronic voiding dysfunction was significantly lower in the LEPRD group than in the bipolar group(P=0.019).Conclusions: It is feasible to perform LEPRD in NPSRH for cervical cancers.This kind of limited energy surgical technique is associated with less blood loss,and leads to improved postoperative bladder function.

温度补偿法解决二元气液平衡系统相图绘制实验中的分馏效应

通过改装二元气液平衡系统相图绘制实验的装置,同时测定了环己烷-乙醇气液系统建立平衡时的沸点和露点温度,绘制并对比未保温、保温和温度补偿条件下的环己烷-乙醇气液相图。研究发现,由于分馏效应的存在,未保温和简易保温情况下,测得的溶液的沸点与露点两者温度均存在较大的差异,利用沸点温度绘制的气相线存在严重失真;对系统进行了温度补偿后根据沸点和露点温度绘制的两条气相线能吻合较好,即气相分馏效应得到了解决。

Purity Identification of Xinkui 19 by SSR Marker Technique

In this study, by using Xinkui 19 and its parents as experimental materials, 100 pairs of SSR molecular markers were screened to obtain specific poly- morphic primers, aiming at providing an accurate and efficient method for identifying the purity of Helianthus annuus L. hybrid seeds. According to the experimen- tal results, by using polymorphic SSR primer 455, the amplified bands of female and male parents were 460 and 430 bp, respectively; by using polymorphic SSR primer 478, the amplified bands of female and male parents were 330 and 350 bp, respectively. The identification results of Xinkui 19 hybrids and its parents with SSR marker technique and field cultivation were basically consistent. SSR primers 455 and 478 could be used for rapid and effective identification of the purity of Xinkui 19 hybrid seeds.

基于蒽和三苯胺基D-π-A结构的蓝色荧光材料在有机发光和紫外探测集成器件中的应用

有机集成化光电子器件兼具了小型化和多功能性的优势,如集成了有机发光和紫外探测的有机发光紫外探测器件(OLED-UVOPDs).这种器件中的有机光电材料的设计仍然面临重大的挑战.在本文中,以蒽为π桥,腈基苯为受体,三苯胺(TPA)和二甲基三苯胺(2mTPA)分别为给体,设计并合成了两种可用于OLED-UVOPD器件的蓝色发光分子,TPA-AN和2mTPA-AN.它们的发光峰分别位于474和488 nm处,荧光量子产率为51.1%和46.6%.通过单载流子器件计算得到其电子迁移率分别为3.96×10^(-5)和6.63×10^(-7)cm^(2)V^(-1)s^(-1).基于TPA-AN的OLED器件表现出强的蓝光发射,最大亮度为43,110 cd m^(-2),最大外量子效率(EQE)为8.1%.它们在OLED-UVOPD集成器件中表现出优异的性能,紫外探测率分别为7.18×10^(11)和2.85×10^(12)Jones,最大EQE分别为8.7%和5.9%.

The origins of catalytic selectivity for the electrochemical conversion of carbon dioxide to methanol

The electrocatalytic conversion of carbon dioxide(CO_(2))into useful fuels and chemical feedstocks is an emerging route to alleviate global warming and reduce reliance on fossil fuels.Methanol(CH_(3)OH),as one of the most significant and widely used liquid fuels that can be generated by CO_(2)reduction,is essential in the chemical industry.In this minireview,we unravel the origins of the selective formation of CH_(3)OH via CO_(2)reduction,including catalyst composition designs,local structure modulations,and electrolyte/catalyst interface regulations.Finally,the remaining challenges and perspectives for the CO_(2)-to-CH_(3)OH reduction are proposed.

An endophytic fungus interacts with the defensinlike protein OsCAL1 to regulate cadmium allocation in rice

Defensin-like proteins are conserved in multicellular organisms and contribute to innate immune re-sponses against fungal pathogens.In rice,defensins play a novel role in regulating cadmium(Cd)efflux from the cytosol.However,whether the antifungal activity of defensins correlates with Cd-efflux function remains unknown.In this study,we isolated an endophytic Fusarium,designed Fo1o,by a comparative mi-crobiome analysis of rice plants grown in a paddy contaminated with Cd.Fo10 is tolerant to high levels of Cd,but is sensitive to the defensin-like protein OsCAL1,which mediates Cd efflux to the apoplast.We found that Fo10 symbiosis in rice is regulated by OsCAL1 dynamics,and Fo10 coordinates multiple plant pro-cesses,including Cd uptake,vacuolar sequestration,efflux to the environment,and formation of Fe pla-ques in the rhizosphere.These processes are dependent on the salicylic acid signaling pathway to keep Cd levels low in the cytosol of rice cells and to decrease Cd levels in rice grains without any yield penalty.Fo10 also plays a role in Cd tolerance in the poaceous crop maize and wheat,but has no observed effects in the eudicot plants Arabidopsis and tomato.Taken together,these findings provide insights into the mech-anistic basis underlying how afungal endophyte and host plant interact to control Cd accumulation in host plants by adapting defense responses to promotethe establishment ofa symbiosis that permits adaptation to high-Cd environments.

交互目标动力理论的新发展与应用展望

交互目标动力理论在自我调节理论的基础上,采用社会关系视角将相互依赖的群体成员(特别是二元群体)视为一个交互目标动力系统,对以往集中于个人层面的目标追求相关理论进行了扩展,关注于多人互动时的目标追求。该理论于2015年提出,在国内受到的关注相对较少。本文从目标实现的过程入手,即目标的设定、目标追求过程和目标结果 ,进一步梳理提炼了这一理论的核心思想,对其与目标设定、目标系统等理论的关系进行辨析,并总结了该理论在组织管理领域、亲密关系领域等的应用。未来研究应进一步完善理论体系,对模型的变量关系进行实证研究,拓展理论的应用领域,并探究交互目标动力在中国文化背景下的特殊性。

All-fiber-based ultrastable laser with long-term frequency stability of 1.1×10^(-14)

We demonstrate an ultrastable miniaturized transportable laser system at 1550 nm by locking it to an optical fiber delay line[FDL].To achieve optimized long-term frequency stability,the FDL was placed into a vacuum chamber with a five-layer thermal shield,and a delicate two-stage active temperature stabilization,an optical power stabilization,and an RF power stabilization were applied in the system.A fractional frequency stability of better than 3.2×10^[-15]at 1 s averaging time and1.1×10^[-14]at 1000 s averaging time was achieved,which is the best long-term frequency stability of an all-fiber-based ultrastable laser observed to date.

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple cancers.However,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear.In the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors.Gain-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in vitro.Moreover,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis.Mechanistically,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling.Collectively,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker.

Electrocatalytic CO_(2) Reduction over Bimetallic Bi-Based Catalysts:A Review

Electrocatalytic reduction of carbon dioxide(CO_(2))to valuable fuels is an up-and-coming approach.Owing to the low cost,environmental friendliness,and high selectivity to formate single product at low overpotentials,bismuth(Bi)-based catalysts have attracted extensive research attention.In this review,the reaction mechanisms of Bi-based catalysts are first introduced,and the bimetallic Bi-based catalysts synthesized by alloying,doping,and loading strategies are reviewed from the aspects of catalyst component,morphology,synthesis procedure,and performance optimization for electrocatalytic CO_(2)reduction.We provide an in-depth discussion of the existing challenges and an outlook for this highly promising kind of electrocatalysis.

The Sources of Bacillus cereus Contamination and their Association with Cereulide Production in Dairy and Cooked Rice Processing Lines

Bacillus cereus,a spore-forming bacterium and frequent cause of food poisoning,poses a safety threat to dairy and rice industries due to its high contamination rates and ability to produce toxins such as cereulide.Because of widespread presence and thermal resistance of the spores,B.cereus cannot be eliminated from the environment and may survive in processing plants.Surviving spores can develop into vegetative cells,leading to a heightened risk of cereulide production in the processing environment.Both spores and vegetative cells have the ability to adhere to the surfaces of dairy plants and form biofilms,serving as the site for cereulide production and accumulation.Therefore,it is crucial for the food industry to address potential sources and pathways of B.cereus contamination and their connections to cereulide production in processing lines.In this review,sources of contamination of B.cereus,including spores,vegetative cells,and biofilms and their potential role in cereulide production at each stage of dairy and cooked rice processing were analyzed.In addition,control methods to prevent B.cereus contamination and cereulide production in processing lines were proposed,offering valuable insights for improving microbial risk management in the food industry.

Outcomes of bictegravir/emtricitabine/tenofovir alafenamide versus efavirenz-based regimens in central China:a real-world assessment

To the Editor:Human immunodeficiency virus(HIV)epidemic poses a significant challenge to global public health.As of 2022,approximately 39.0 million people worldwide were living with HIV.[1]With the ongoing evolution of combined antiretroviral therapy(cART),HIV infection has transformed into a manageable chronic disease requiring long-term treatment.Among the various classes of antiretroviral(ARV)drugs,integrase strand transfer inhibitor(INSTI)-based regimens,known for potency and tolerability,have emerged as the predominant treatment modality worldwide.The nextgeneration of INSTI,bictegravir(BIC),received the Food and Drug Administration(FDA)approval in 2018 as a single-tablet regimen(STR)containing BIC(50 mg)/emtricitabine(FTC,200 mg)/tenofovir alafenamide(TAF,25 mg)for once daily.It has been endorsed as the preferred choice for treatment-naive patients by major guidelines,including the 2021 edition of the China Acquired Immune Deficiency Syndrome(AIDS)Diagnosis and Treatment Guidelines.[2]In China,people living with HIV(PLWH)are provided with flexible cART options,including the National Reimbursement Drug List(NRDL),self-pay drugs,and free drugs.Since being included in NRDL in 2021,BIC/FTC/TAF have gained popularity among an increasing number of patients.

古尔班通古特沙漠固定沙丘上白梭梭和梭梭的空间分布及种间关联性

为了探讨沙漠中固沙灌木种群共存和演替机制,本文基于古尔班通古特沙漠东南缘固定沙丘上白梭梭(Haloxylon persicum)和梭梭(H.ammodendron)种群的地理位置和生长发育阶段信息(幼株、营养株、生殖株和死株),采用点格局分析方法(g(r)函数)及Monte-Carlo随机模拟检验和零模型选取的方法,分析了固沙灌木白梭梭和梭梭种群不同生长发育阶段在0-20 m尺度内的空间分布格局及种间关联性。结果表明:(1)两个种群在研究尺度范围内呈聚集分布,随着尺度的增大,其聚集强度逐渐减弱;(2)两个种群整体上呈负关联关系,尺度越大负关联关系越显著;(3)白梭梭种群生长发育阶段相差越大,个体间正关联关系越显著;梭梭种群生长发育阶段越接近,个体间正关联关系越显著;(4)两个种群中龄级较大的个体(如营养株、生殖株和死株)会对对方种群中龄级较小的幼株产生一定的抑制作用;同时,随着两个种群中个体的成长,双方受到的抑制作用逐渐减弱,主要表现为正关联和无关联。总体而言,古尔班通古特沙漠固定沙丘白梭梭和梭梭种群的分布格局整体上为聚集分布,随龄级增加聚集性减弱,受生境异质性和扩散限制的影响明显。种间关系多为负相关,种内不同生长发育阶段之间均为正关联关系。

Research progress of defect-engineered UiO-66(Zr)MOFs for photocatalytic hydrogen production

In recent years,defect-engineered Zr-based UiO-66 metal-organic frameworks(UiO-66(Zr)metalorganic frameworks(MOFs))have shown huge advantages in catalytic,functional materials,adsorption,and other fields due to their large surface areas,well-ordered porous structures,and flexible tailorability.It is extremely challenging to introduce defect sites in the synthesis of MOFs to regulate the physicochemical properties of materials such as(energy band structure,pore structure,etc.)to obtain an excellent performance.This paper reviews the recent research results of synthesis methods,characterization technologies,and application fields of defect-engineered UiO-66(Zr)MOFs materials in order to provide new insights to synthesize high-performance UiO-66(Zr)MOFs materials and promote the development of UiO-66(Zr)in various fields.

Isolated ultrasmall Bi nanosheets for efficient CO_(2)-to-formate electroreduction

Electrochemical reduction of CO_(2) to valuable formate as liquid fuel is a promising way to alleviate the greenhouse effect.The edge active sites in bismuth(Bi)nanosheets play a critical role in the electrochemical reduction of CO_(2) into formate,which enable the operation of CO_(2) reduction with high cathodic energy efficiency,especially under large current densities of≥200 mA/cm^(2).However,the undesirable reconstruction of small Bi nanosheets into large nanosheets leads to the decreasing of edge active sites during electrocatalysis.Here we report stable isolated ultrasmall bismuth nanosheets-synthesized by in-situ electrochemical transformation of ligands covered bismuth vanadate-on silver nanowires as an efficient electrocatalyst for CO_(2)-to-formate reduction.The cooperative electrocatalyst achieves a formate current density of 186 mA/cm^(2) and a cathodic energy efficiency of 75%for formate,which is the only best compared to the literature results.Operand。Raman and morphologic measurements demonstrate that the excellent energy utilization of the electrocatalyst is originated from the rich edge active sites with Bi-O species of the ultrasmall Bi nanosheets.