The ZrB 2 particles firstly modified Mg_(94)Zn_(2.5)Y_(2.5)Mn 1 alloy.And the microstructures and mechanical performances of the modified alloys were studied systematically.The results showed that the moderate additio...The ZrB 2 particles firstly modified Mg_(94)Zn_(2.5)Y_(2.5)Mn 1 alloy.And the microstructures and mechanical performances of the modified alloys were studied systematically.The results showed that the moderate addition of ZrB 2 accelerated the development of long-period stacking ordered(LPSO)structure and refined the grain size.The grains in ZrB 2-modified alloys were nearly equiaxed with a homogeneous size.When 0.0075 wt%ZrB 2 was added,the as-cast alloy with the finest grains(24.87μm)presented desirable mechanical properties(especially ductility)with maximum tensile strength and ductility of 225 MPa and 17.5%,respectively.展开更多
The influences of Mo contents on mechanical properties,biocorrosion and cytocompatibility of as-cast Mg-6Zn-8.16Y-2.02Mn-xMo(x=0.0,0.1,0.3,0.5,0.7 wt%) alloys were firstly investigated.Appropriate amount of Mo was con...The influences of Mo contents on mechanical properties,biocorrosion and cytocompatibility of as-cast Mg-6Zn-8.16Y-2.02Mn-xMo(x=0.0,0.1,0.3,0.5,0.7 wt%) alloys were firstly investigated.Appropriate amount of Mo was conducive to grain refinement and the formation of long-period stacking ordered structure with continuous distribution,which was advantageous to mechanical properties and corrosion resistance.Mg-6Zn-8.16Y-2.02Mn-0.3Mo exhibited the ultimate tensile strength of 265.0 MPa,elongation of 13.5% and the lowest weight loss rate in Hank’s solution.Moreover,the cell toxicity cultured in 25% extract was evaluated and the alloy with 0.3 wt% Mo exhibited the best cytocompatibility.Thus,the alloy was expected to become a novel biodegradable implant material.展开更多
VKORC1 and CYP2C9 have been shown to be strongly associated with Warfarin dosing. However, it is still unclear whether other common genetic variants also contribute to the variation in Warfarin dosing. In the present ...VKORC1 and CYP2C9 have been shown to be strongly associated with Warfarin dosing. However, it is still unclear whether other common genetic variants also contribute to the variation in Warfarin dosing. In the present study, we aim to investigate possible effects of single nucleotide polymorphisms （SNPs） in other candidate genes （CYP4F2, CACNAIC and STX4）, as well as several factors, on stable daily Warfarin dosage （DWMD） in Chinese cardiovascular disease patients. 207 cardiovascular disease patients treated with Warfarin were recruited from Beijing Hospital. DNA was extracted from the blood samples collected one day after Warfarin administration. Nine SNPs （i.e. rs9923231, rs9934438, rs7294, rs1799853, rs1057910, rs4086116, rs2108622, rs216013 and rs10871454 in five genes （i.e. VKORC1, CYP2Cg, CYP4F2, CACNA1C and STX4） were analyzed using ligase detection reactions （LDR）. Univariate analyses and multiple linear regression analyses were performed to analyze the associations between SNPs and other factors （i.e. body surface area （BSA）, Statin medication） and DWMD. Four SNPs （i.e. rs9923231, rs9934438, rs7294 in VKORC1 and rsi0871454 in STX4） had significant statistically effects on DWMD. The multiple linear regression model showed that rs10871454 in STX4, BSA, statin medication, and rs1057910 in CYP2C9 were the significant independent covariates of DWMD. SNP （rs10871454） in STX4 had the strongest effect on Warfarin dosing among the examined candidate genes, indicating that it might serve as a key genetic factor for prediciting the Warfarin maintenance dose in Chinese patients.展开更多
基金support of Shanxi key laboratory of advanced magnesium-based material,Na-tional Natural Science Foundation of China(No.51474153 and 51574175)Ph.D.Programs Foundation of Ministry of Education of China(20111402110004)。
文摘The ZrB 2 particles firstly modified Mg_(94)Zn_(2.5)Y_(2.5)Mn 1 alloy.And the microstructures and mechanical performances of the modified alloys were studied systematically.The results showed that the moderate addition of ZrB 2 accelerated the development of long-period stacking ordered(LPSO)structure and refined the grain size.The grains in ZrB 2-modified alloys were nearly equiaxed with a homogeneous size.When 0.0075 wt%ZrB 2 was added,the as-cast alloy with the finest grains(24.87μm)presented desirable mechanical properties(especially ductility)with maximum tensile strength and ductility of 225 MPa and 17.5%,respectively.
基金This research was financially supported by the National Natural Science Foundation of China(Nos.51474153 and 51574175).
文摘The influences of Mo contents on mechanical properties,biocorrosion and cytocompatibility of as-cast Mg-6Zn-8.16Y-2.02Mn-xMo(x=0.0,0.1,0.3,0.5,0.7 wt%) alloys were firstly investigated.Appropriate amount of Mo was conducive to grain refinement and the formation of long-period stacking ordered structure with continuous distribution,which was advantageous to mechanical properties and corrosion resistance.Mg-6Zn-8.16Y-2.02Mn-0.3Mo exhibited the ultimate tensile strength of 265.0 MPa,elongation of 13.5% and the lowest weight loss rate in Hank’s solution.Moreover,the cell toxicity cultured in 25% extract was evaluated and the alloy with 0.3 wt% Mo exhibited the best cytocompatibility.Thus,the alloy was expected to become a novel biodegradable implant material.
文摘VKORC1 and CYP2C9 have been shown to be strongly associated with Warfarin dosing. However, it is still unclear whether other common genetic variants also contribute to the variation in Warfarin dosing. In the present study, we aim to investigate possible effects of single nucleotide polymorphisms （SNPs） in other candidate genes （CYP4F2, CACNAIC and STX4）, as well as several factors, on stable daily Warfarin dosage （DWMD） in Chinese cardiovascular disease patients. 207 cardiovascular disease patients treated with Warfarin were recruited from Beijing Hospital. DNA was extracted from the blood samples collected one day after Warfarin administration. Nine SNPs （i.e. rs9923231, rs9934438, rs7294, rs1799853, rs1057910, rs4086116, rs2108622, rs216013 and rs10871454 in five genes （i.e. VKORC1, CYP2Cg, CYP4F2, CACNA1C and STX4） were analyzed using ligase detection reactions （LDR）. Univariate analyses and multiple linear regression analyses were performed to analyze the associations between SNPs and other factors （i.e. body surface area （BSA）, Statin medication） and DWMD. Four SNPs （i.e. rs9923231, rs9934438, rs7294 in VKORC1 and rsi0871454 in STX4） had significant statistically effects on DWMD. The multiple linear regression model showed that rs10871454 in STX4, BSA, statin medication, and rs1057910 in CYP2C9 were the significant independent covariates of DWMD. SNP （rs10871454） in STX4 had the strongest effect on Warfarin dosing among the examined candidate genes, indicating that it might serve as a key genetic factor for prediciting the Warfarin maintenance dose in Chinese patients.
