ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability o...ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability of their co-occurrence. Consequently, clinical data and treatment strategies for their simultaneous presence are remarkably scarce. This report details the first recorded case of a sarcomatoid, poorly differentiated lung adenocarcinoma harboring both a ROS1 fusion and an EGFR mutation, alongside ARID1A and NFKBIA gene mutations. Moreover, this case study encompasses a review of instances featuring concurrent ROS1 and EGFR mutations. The identified genetic alterations in ROS1, EGFR, ARID1A, and NFKBIA are pivotal in the etiology of NSCLC. These mutations significantly influence disease progression and are essential for the development of personalized therapeutic approaches. Recognizing the unique genetic profiles in patients permits healthcare providers to devise customized treatment regimens that target these specific mutations, thereby enhancing patient outcomes in NSCLC.展开更多
We demonstrate a method to generate tunable triangular and honeycomb plasma structures via dielectric barrier discharge with uniquely designed mesh-liquid electrodes.A rapid reconfiguration between the triangular latt...We demonstrate a method to generate tunable triangular and honeycomb plasma structures via dielectric barrier discharge with uniquely designed mesh-liquid electrodes.A rapid reconfiguration between the triangular lattice and honeycomb lattice has been realized.Novel structures comprised of triangular plasma elements have been observed and a robust angular reorientation of the triangular plasma elements withθ=π/3 is suggested.An active control on the geometrical shape,size and angular orientation of the plasma elements has been achieved.Moreover,the formation mechanism of different plasma structures is studied by spatial-temporal resolved measurements using a high-speed camera.The photonic band diagrams of the plasma structures are calculated by use of finite element method and two large omnidirectional band gaps have been obtained for honeycomb lattices,demonstrating that such plasma structures can be potentially used as plasma photonic crystals to manipulate the propagation of microwaves.The results may offer new strategies for engineering the band gaps and provide enlightenments on designing new types of 2D and possibly 3D metamaterials in other fields.展开更多
文摘ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability of their co-occurrence. Consequently, clinical data and treatment strategies for their simultaneous presence are remarkably scarce. This report details the first recorded case of a sarcomatoid, poorly differentiated lung adenocarcinoma harboring both a ROS1 fusion and an EGFR mutation, alongside ARID1A and NFKBIA gene mutations. Moreover, this case study encompasses a review of instances featuring concurrent ROS1 and EGFR mutations. The identified genetic alterations in ROS1, EGFR, ARID1A, and NFKBIA are pivotal in the etiology of NSCLC. These mutations significantly influence disease progression and are essential for the development of personalized therapeutic approaches. Recognizing the unique genetic profiles in patients permits healthcare providers to devise customized treatment regimens that target these specific mutations, thereby enhancing patient outcomes in NSCLC.
基金supported by National Natural Science Foundation of China(Nos.11875014,11975089)the Natural Science Foundation of Hebei Province(Nos.A2021201010,A2021201003,and A2017201099)。
文摘We demonstrate a method to generate tunable triangular and honeycomb plasma structures via dielectric barrier discharge with uniquely designed mesh-liquid electrodes.A rapid reconfiguration between the triangular lattice and honeycomb lattice has been realized.Novel structures comprised of triangular plasma elements have been observed and a robust angular reorientation of the triangular plasma elements withθ=π/3 is suggested.An active control on the geometrical shape,size and angular orientation of the plasma elements has been achieved.Moreover,the formation mechanism of different plasma structures is studied by spatial-temporal resolved measurements using a high-speed camera.The photonic band diagrams of the plasma structures are calculated by use of finite element method and two large omnidirectional band gaps have been obtained for honeycomb lattices,demonstrating that such plasma structures can be potentially used as plasma photonic crystals to manipulate the propagation of microwaves.The results may offer new strategies for engineering the band gaps and provide enlightenments on designing new types of 2D and possibly 3D metamaterials in other fields.
