Exploratory study on resilience and its influencing factors among hospital nurses in Guangzhou,China

Background:Currently,building resilience in nurses is recognized as an important factor that helps maintain their health and stay in their profession;thus,identifying which factors can help them build resilience is necessary.Methods:A cross-sectional survey design was used,and 1356 nurses from 11 general hospitals in Guangzhou,China,were assessed using the Chinese version of the Conner-Davidson Resilience Scale,the General Self-Efficacy Scale,the Simplified Coping Style Questionnaire,and the Job Stress Scale of Chinese nurses.The demographic characteristics of participants were also gathered.Results:The mean total score of nurses' resilience is 59.99 (SD 13.59),which was significantly lower (P < 0.001) than that of the general people in China.The regression analysis affirmed that the factors which influence the resilience of nurses include self-efficacy,coping style,job stress,and education level (R2 =49.4%,P < 0.001).Conclusion:Nurses had low resilience.They could not effectively cope with job challenges and recover from adversity.Strengthening self-efficacy,choosing active coping,decreasing job stress,and enhancing educational training can effectively improve their resilience.

Role of DSC1 in Drosophila melanogaster synaptic activities in response to haedoxan A

Drosophila sodium channel 1 (DSC1) encodes a voltage-gated divalent cation channel that mediates neuronal excitability in insects. Previous research revealed that DSC1 knockout Drosophila melanogaster conferred different susceptibility to insecticides, which indicated the vital regulation role of DSC1 under insecticide stress. Haedoxan A (HA) is a lignan compound isolated from Phryma leptostachya, and we found that HA has excellent insecticidal activity and is worthy of further study as a botanical insecticide. Herein, we performed bioassay and electrophysiological experiments to test the biological and neural changes in the larval Drosophila with/without DSC1 knockout in response to HA. Bioassay results showed that knockout of DSC1 reduced the sensitivity to HA in both w1118 (a common wild-type strain in the laboratory) and parats1 (a pyrethroid-resistant strain) larvae. Except for parats1/DSC1−/−, electrophysiology results implicated that HA delayed the decay rate and increased the frequency of miniature excitatory junctional potentials of Drosophila from w1118, parats1, and DSC1−/− strains. Moreover, the neuromuscular synapse excitatory activities of parats1/DSC1−/− larvae were more sensitive to HA than DSC1−/− larvae, which further confirmed the functional contribution of DSC1 to neuronal excitability. Collectively, these results indicated that the DSC1 channel not only regulated the insecticidal activity of HA, but also maintained the stability of neural circuits through functional interaction with voltage-gated sodium channels. Therefore, our study provides useful information for elucidating the regulatory mechanism of DSC1 in the neural system of insects involving the action of HA derived from P. leptostachya.