Facial prostheses have developed significantly in the last 10 years,especially between 2016 and 2021.This development is mainly due to the great progress made in the fields of biocompatible materials,digital technolog...Facial prostheses have developed significantly in the last 10 years,especially between 2016 and 2021.This development is mainly due to the great progress made in the fields of biocompatible materials,digital technology,and three-dimensional printing technology,which provides guarantee for low allergy,high biosimulation,comfort,and satisfactory usability.Treatment teams typically consist of plastic surgeons,material experts,engineers,and computer scientists who have extensive clinical experience.These teams successfully implement an integrated,multidisciplinary model by prioritizing the reasonable expectations of both the physician and patient,leading to improved patient satisfaction and compliance with prosthetic constraints.This study aimed to review the concept,development status,existing problems,and future of facial prosthesis.展开更多
The northern Tibetan Plateau is a climatically sensitive zone influenced by monsoon and westerly winds.In summer,water vapor transport can reach Qinghai Lake and the eastern section of the Qilian Mountains;in winter,w...The northern Tibetan Plateau is a climatically sensitive zone influenced by monsoon and westerly winds.In summer,water vapor transport can reach Qinghai Lake and the eastern section of the Qilian Mountains;in winter,westerly winds mainly control the climate.This article compares the wet/dry changes in the region during the mid-Holocene(MH)warm period,the medieval climate anomaly(MCA),the current warm period(CWP),and the future warm period from the perspective of paleoclimate.We found that the MH warm period was mainly affected by the orbit-controlled East Asian summer monsoon,and the region showed warm and humid climate characteristics.The MCA was mainly controlled by solar radiation,and there was a warm and dry phenomenon.The CWP and the future warm period are mainly controlled by the rise in temperature caused by the increase in greenhouse gases,and the climate is becoming more arid.The wet/dry patterns in the CWP and the future warm period in the next century on the northern Tibetan Plateau are similar to those in the MCA.Continued warming will lead to the expansion of the westerly belt and a gradually humid climate.The future wet/dry changes will be more similar to the MH warm period.展开更多
Metabolites of microorganisms have long been considered as potential sources for drug discovery.In this study,fve new depsidone derivatives,talaronins A-E(1-5)and three new xanthone derivatives,talaronins F-H(6-8),tog...Metabolites of microorganisms have long been considered as potential sources for drug discovery.In this study,fve new depsidone derivatives,talaronins A-E(1-5)and three new xanthone derivatives,talaronins F-H(6-8),together with 16 known compounds(9-24),were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362.The structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher’s method.Compounds 1 and 2 each attached a dimethyl acetal group at the aromatic ring.A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursors such as chrysophanol or rheochrysidin.The antimicrobial activity assay indicated that compounds 5,9,10,and 14 showed potent activity against Helicobacter pylori with minimum inhibitory concentration(MIC)values in the range of 2.42-36.04μmol/L.While secalonic acid D(19)demonstrated signifcant antimicrobial activity against four strains of H.pylori with MIC values in the range of 0.20 to 1.57μmol/L.Furthermore,secalonic acid D(19)exhibited cytotoxicity against cancer cell lines Bel-7402 and HCT-116 with IC_(50) values of 0.15 and 0.19μmol/L,respectively.The structure–activity relationship of depsidone derivatives revealed that the presence of the lactone ring and the hydroxyl at C-10 was crucial to the antimicrobial activity against H.pylori.The depsidone derivatives are promising leads to inhibit H.pylori and provide an avenue for further development of novel antibiotics.展开更多
文摘Facial prostheses have developed significantly in the last 10 years,especially between 2016 and 2021.This development is mainly due to the great progress made in the fields of biocompatible materials,digital technology,and three-dimensional printing technology,which provides guarantee for low allergy,high biosimulation,comfort,and satisfactory usability.Treatment teams typically consist of plastic surgeons,material experts,engineers,and computer scientists who have extensive clinical experience.These teams successfully implement an integrated,multidisciplinary model by prioritizing the reasonable expectations of both the physician and patient,leading to improved patient satisfaction and compliance with prosthetic constraints.This study aimed to review the concept,development status,existing problems,and future of facial prosthesis.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0202)the National Natural Science Foundation of China(Grant Nos.42371159,42077415)the Program of Introducing Talents of Discipline to University(Grant No.BP0618001)。
文摘The northern Tibetan Plateau is a climatically sensitive zone influenced by monsoon and westerly winds.In summer,water vapor transport can reach Qinghai Lake and the eastern section of the Qilian Mountains;in winter,westerly winds mainly control the climate.This article compares the wet/dry changes in the region during the mid-Holocene(MH)warm period,the medieval climate anomaly(MCA),the current warm period(CWP),and the future warm period from the perspective of paleoclimate.We found that the MH warm period was mainly affected by the orbit-controlled East Asian summer monsoon,and the region showed warm and humid climate characteristics.The MCA was mainly controlled by solar radiation,and there was a warm and dry phenomenon.The CWP and the future warm period are mainly controlled by the rise in temperature caused by the increase in greenhouse gases,and the climate is becoming more arid.The wet/dry patterns in the CWP and the future warm period in the next century on the northern Tibetan Plateau are similar to those in the MCA.Continued warming will lead to the expansion of the westerly belt and a gradually humid climate.The future wet/dry changes will be more similar to the MH warm period.
基金This research was funded by grants from National Key Research and Development Program of China(2018YFC0311002)High-Level Talent Special Support Plan of Zhejiang Province(2019R52009).
文摘Metabolites of microorganisms have long been considered as potential sources for drug discovery.In this study,fve new depsidone derivatives,talaronins A-E(1-5)and three new xanthone derivatives,talaronins F-H(6-8),together with 16 known compounds(9-24),were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362.The structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher’s method.Compounds 1 and 2 each attached a dimethyl acetal group at the aromatic ring.A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursors such as chrysophanol or rheochrysidin.The antimicrobial activity assay indicated that compounds 5,9,10,and 14 showed potent activity against Helicobacter pylori with minimum inhibitory concentration(MIC)values in the range of 2.42-36.04μmol/L.While secalonic acid D(19)demonstrated signifcant antimicrobial activity against four strains of H.pylori with MIC values in the range of 0.20 to 1.57μmol/L.Furthermore,secalonic acid D(19)exhibited cytotoxicity against cancer cell lines Bel-7402 and HCT-116 with IC_(50) values of 0.15 and 0.19μmol/L,respectively.The structure–activity relationship of depsidone derivatives revealed that the presence of the lactone ring and the hydroxyl at C-10 was crucial to the antimicrobial activity against H.pylori.The depsidone derivatives are promising leads to inhibit H.pylori and provide an avenue for further development of novel antibiotics.
