期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Aldo-keto reductase 1B:Much learned,much more to do
1
作者 yaya zhao Miaomiao Zhang +4 位作者 Huaping Li Yiwen Yang Xiaofu Lu Junjing Yu Lei Pan 《hLife》 2024年第4期154-178,共25页
The aldo-keto reductase 1B(AKR1B)subfamily was initially known for its association with the pathogenesis of secondary diabetic complications such as retinopathy,neuropathy,nephropathy,and cataracts.Unfortunately,over ... The aldo-keto reductase 1B(AKR1B)subfamily was initially known for its association with the pathogenesis of secondary diabetic complications such as retinopathy,neuropathy,nephropathy,and cataracts.Unfortunately,over the past few decades,all drug development efforts targeting this family have failed for one reason or another.Recently,a growing body of evidence showing the deep involvement of AKR1B in metabolic reprogramming and production of signaling metabolites has led to a re-evaluation of their role in the pathogenesis of several immunometabolism-related diseases,such as gastrointestinal diseases,psoriasis,congenital disorders of glycosylation,carcinogenesis,even progression,and acquired chemoresistance.Therefore,in this review,we will summarize the current knowledge of AKR1B,highlighting their potential function in regulating immune cell function and then inflammatory complications.We will also explore how discovering this new insight into this old enzyme is essential for envisioning potential therapeutic strategies to prevent or treat inflammatory diseases. 展开更多
关键词 aldo-keto reductase 1B gastrointestinal diseases PSORIASIS congenital disorder of glycosylation CANCER aldo-keto reductase 1B inhibitor
原文传递
Effect of autaptic delay signal on spike-timing precision of single neuron
2
作者 马璇 赵鸭鸭 +2 位作者 王亚峰 陈月玲 王恒通 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第3期613-620,共8页
Experimental and theoretical studies have reported that the precise firing of neurons is crucial for sensory representation.Autapse serves as a special synapse connecting neuron and itself,which has also been found to... Experimental and theoretical studies have reported that the precise firing of neurons is crucial for sensory representation.Autapse serves as a special synapse connecting neuron and itself,which has also been found to improve the accuracy of neuronal response.In current work,the effect of autaptic delay signal on the spike-timing precision is investigated on a single autaptic Hodgkin–Huxley neuron in the present of noise.The simulation results show that both excitatory and inhibitory autaptic signals can effectively adjust the precise spike time of neurons with noise by choosing the appropriate coupling strength g and time delay of autaptic signalτ.The g–τparameter space is divided into two regions:one is the region where the spike-timing precision is effectively regulated;the other is the region where the neuronal firing is almost not regulated.For the excitatory and inhibitory autapse,the range of parameters causing the accuracy of neuronal firing is different.Moreover,it is also found that the mechanisms of the spike-timing precision regulation are different for the two kinds of autaptic signals. 展开更多
关键词 autapse time delay spike-timing precision
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部