Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell dysfunction.SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,a...Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell dysfunction.SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural byproduct.The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study.SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin secretion.Interestingly,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the pancreas.To have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling pathways.These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.展开更多
储能技术是构建以新能源为主体的新型电力系统的关键技术和维持微网可靠稳定运行的重要保证。国内外现有理论研究及示范工程主要集中于单级式链式储能系统,功率模块与电池系统之间无源连接,结构简单但控制自由度不高。同时,针对基于链...储能技术是构建以新能源为主体的新型电力系统的关键技术和维持微网可靠稳定运行的重要保证。国内外现有理论研究及示范工程主要集中于单级式链式储能系统,功率模块与电池系统之间无源连接,结构简单但控制自由度不高。同时,针对基于链式储能的电池荷电状态(state of charge,SOC)不均衡问题,现有的相内SOC均衡控制策略存在不同负载率适应性不足、极度不均衡时可能过调制等缺点,为此,文中基于两级式链式储能系统,研究其总体控制策略,对相间、相内SOC均衡策略进行分析,并提出一种自适应的相内SOC均衡策略,详细说明均衡控制参数的设计原则。该策略能有效地改善链式储能系统在轻载、重载等不同工况下的适应性和均衡效果。最终通过仿真验证了所提控制策略的可行性和有效性,从而为工程实施提供理论储备和技术支撑。展开更多
基金financially supported by the Doctoral Scientific Research Start-up Foundation of the Harbin University of Commerce (2019DS098)the Young Innovation Talents Project from the Harbin University of Commerce (2019CX31)the Graduate Innovation Fund from the Harbin University of Commerce (YJSCX2019–615HSD)。
文摘Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell dysfunction.SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural byproduct.The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study.SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin secretion.Interestingly,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the pancreas.To have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling pathways.These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.
文摘储能技术是构建以新能源为主体的新型电力系统的关键技术和维持微网可靠稳定运行的重要保证。国内外现有理论研究及示范工程主要集中于单级式链式储能系统,功率模块与电池系统之间无源连接,结构简单但控制自由度不高。同时,针对基于链式储能的电池荷电状态(state of charge,SOC)不均衡问题,现有的相内SOC均衡控制策略存在不同负载率适应性不足、极度不均衡时可能过调制等缺点,为此,文中基于两级式链式储能系统,研究其总体控制策略,对相间、相内SOC均衡策略进行分析,并提出一种自适应的相内SOC均衡策略,详细说明均衡控制参数的设计原则。该策略能有效地改善链式储能系统在轻载、重载等不同工况下的适应性和均衡效果。最终通过仿真验证了所提控制策略的可行性和有效性,从而为工程实施提供理论储备和技术支撑。
