目的:探讨低浓度利多卡因行下牙槽、舌、颊神经一次阻滞麻醉的效果。方法:采用自身对照研究,前瞻性分析3 mL 1%利多卡因1∶100000肾上腺素(低浓度组)或3 mL 2%利多卡因1∶100000肾上腺素(高浓度组)行下牙槽、舌、颊神经阻滞麻醉拔除下...目的:探讨低浓度利多卡因行下牙槽、舌、颊神经一次阻滞麻醉的效果。方法:采用自身对照研究,前瞻性分析3 mL 1%利多卡因1∶100000肾上腺素(低浓度组)或3 mL 2%利多卡因1∶100000肾上腺素(高浓度组)行下牙槽、舌、颊神经阻滞麻醉拔除下颌智牙的差异。患者术后经过21 d的洗脱期,选择对应浓度的利多卡因拔除对侧阻生牙。分析2组间注射时疼痛水平(疼痛评估量表,NRS)、麻醉起效时间、麻醉深度及麻醉持续时间的差异。采用SPSS 17.0软件包对数据进行统计学分析。结果:21例患者(平均年龄24岁)完成试验,其中62%为女性。低浓度组的疼痛水平(1.09,95%CI,0.77~1.41)显著低于高浓度组(1.66,95%CI,1.33-1.99)(P=0.010)。低浓度组下牙槽、颊、舌神经阻滞麻醉起效时间(52~63 s)显著快于高浓度组(259~335 s)(P=0.000)。下牙槽、舌、颊神经麻醉深度2组之间未见显著差异(P=0.751)。在疼痛NRS值为1~3的患者中,低浓度组,9例(100%)均在分牙时疼痛(下牙槽神经麻醉深度浅);高浓度组3例(43%)分牙时疼痛,4例(57%)翻瓣时疼痛(颊神经麻醉深度浅)(P=0.019)。高浓度组麻醉持续时间比低浓度组平均长61 min(52~69 min)(P=0.000)。结论:用低浓度利多卡因组行下牙槽、舌、颊神经阻滞麻醉起效快,注射时疼痛水平低,术后下唇麻木不适感消失快。术中轻微疼痛,高浓度组常因颊神经麻醉深度较浅引起,低浓度组因下牙槽神经麻醉深度较浅引起。展开更多
目的:探讨三维重建可视化技术在埋伏牙拔除术前定位和设计中的应用价值。方法:以2017-12-2018-12期间收治的97例埋伏牙患者为研究对象,术前拍摄CBCT,将数据以DICOM格式导入Simplant Pro 11.0软件,构建颌骨和牙列的三维可视化模型,对埋...目的:探讨三维重建可视化技术在埋伏牙拔除术前定位和设计中的应用价值。方法:以2017-12-2018-12期间收治的97例埋伏牙患者为研究对象,术前拍摄CBCT,将数据以DICOM格式导入Simplant Pro 11.0软件,构建颌骨和牙列的三维可视化模型,对埋伏牙进行定位分析,观察其与邻近解剖结构的关系,设计拔牙方案。手术方案确定后,在全麻下按照术前计划实施拔牙手术。结果:97例患者共123颗埋伏牙均按照术前设计的方案顺利拔除,无1例在术中改变手术方案。所有患者均未发生神经损伤、上颌窦或鼻底穿通、邻牙损伤、异常出血等并发症。结论:三维重建可视化技术有助于埋伏牙的精确定位和拔牙方案的术前设计,值得临床推广。展开更多
Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be low-expressed.The current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse mod...Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be low-expressed.The current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy volunteers.Sepsis patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data analysis.Adult male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 cells.Results:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients vs.the healthy control(P<0.001),as well as in the sepsis non-survivor group vs.the sepsis survivor group(P<0.001,P=0.0338,or P=0.0013,respectively).Lower serum VDBP level was associated with higher Acute Physiology and Chronic Health Evaluation(APACHE)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,P<0.001)and total protein(TP,r=0.263,P=0.02).In CLP mice,there was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day 7.VDBP was also decreased in LPS-treated THLE2 cells(P<0.001).VDBP overexpression reduced LPS-induced THLE2 damage.Reduced damage was associated with decreased oxidative stress and inactivation of the c-Jun N-terminal kinase signaling pathway.Conclusion:VDBP may be protective against sepsis-induced liver injury.展开更多
We introduce a novel numerical method for solving two-sided space fractional partial differential equations in two-dimensional case.The approximation of the space fractional Riemann-Liouville derivative is based on th...We introduce a novel numerical method for solving two-sided space fractional partial differential equations in two-dimensional case.The approximation of the space fractional Riemann-Liouville derivative is based on the approximation of the Hadamard finite-part integral which has the convergence order O(h^3-a),where h is the space step size and α∈(1,2)is the order of Riemann-Liouville fractional derivative.Based on this scheme,we introduce a shifted finite difference method for solving space fractional partial differential equations.We obtained the error estimates with the convergence orders O(τ+h^3-a+h^β),where τ is the time step size and β>0 is a parameter which measures the smoothness of the fractional derivatives of the solution of the equation.Unlike the numerical methods for solving space fractional partial differential equations constructed using the standard shifted Griinwald-Letnikov formula or higher order Lubich's methods which require the solution of the equation to satisfy the homogeneous Dirichlet boundary condition to get the firstorder convergence,the numerical method for solving the space fractional partial differential equation constructed using the Hadamard finite-part integral approach does not require the solution of the equation to satisfy the Dirichlet homogeneous boundary condition.Numerical results show that the experimentally determined convergence order obtained using the Hadamard finite-part integral approach for solving the space fractional partial differential equation with non-homogeneous Dirichlet boundary conditions is indeed higher than the convergence order obtained using the numerical methods constructed with the standard shifted Griinwald-Letnikov formula or Lubich's higher order approximation schemes.展开更多
A solid superacid catalyst Pt-SO42-/ZrO2-A12O3 for n-pentane isomerization, was prepared by incipient-wetness impregnation. Preparetion conditions, namely, calcination temperature, concentration of sulfuric acid solut...A solid superacid catalyst Pt-SO42-/ZrO2-A12O3 for n-pentane isomerization, was prepared by incipient-wetness impregnation. Preparetion conditions, namely, calcination temperature, concentration of sulfuric acid solution used in impregnation and Al2O3 concentration, were varied to investigate the effects on catalytic performance of Pt-SO42-/ZrO2-A12O3. The results showed that the PtSZA catalyst exhibited excellent catalytic performance for n-pentane isomerization. Under optimized preparation conditions of calcination temperature of 650°C, reaction time for 3 h, concentration of sulfuric acid solution for 0.5 mol/L, 30% of Al2O3 concentration and 0.3% of Pt concentration, the n-pentane conversion and isopentane selectivity of Pt-SO42-/ZrO2-A12O3 could reach up to 62.17% and 91.60%, respectively.展开更多
文摘目的:探讨三维重建可视化技术在埋伏牙拔除术前定位和设计中的应用价值。方法:以2017-12-2018-12期间收治的97例埋伏牙患者为研究对象,术前拍摄CBCT,将数据以DICOM格式导入Simplant Pro 11.0软件,构建颌骨和牙列的三维可视化模型,对埋伏牙进行定位分析,观察其与邻近解剖结构的关系,设计拔牙方案。手术方案确定后,在全麻下按照术前计划实施拔牙手术。结果:97例患者共123颗埋伏牙均按照术前设计的方案顺利拔除,无1例在术中改变手术方案。所有患者均未发生神经损伤、上颌窦或鼻底穿通、邻牙损伤、异常出血等并发症。结论:三维重建可视化技术有助于埋伏牙的精确定位和拔牙方案的术前设计,值得临床推广。
基金the Clinical Research Support Fund of Chinese PLA General Hospital(2018FC-WJFWZX-1-03)Youth Talents Promotion Project of China(17-JCJQ-QT-036)Natural Science Foundation of Beijing(7214254).
文摘Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be low-expressed.The current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy volunteers.Sepsis patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data analysis.Adult male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 cells.Results:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients vs.the healthy control(P<0.001),as well as in the sepsis non-survivor group vs.the sepsis survivor group(P<0.001,P=0.0338,or P=0.0013,respectively).Lower serum VDBP level was associated with higher Acute Physiology and Chronic Health Evaluation(APACHE)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,P<0.001)and total protein(TP,r=0.263,P=0.02).In CLP mice,there was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day 7.VDBP was also decreased in LPS-treated THLE2 cells(P<0.001).VDBP overexpression reduced LPS-induced THLE2 damage.Reduced damage was associated with decreased oxidative stress and inactivation of the c-Jun N-terminal kinase signaling pathway.Conclusion:VDBP may be protective against sepsis-induced liver injury.
基金Y.Wang's research was supported by the Natural Science Foundation of Luliang University(XN201510).
文摘We introduce a novel numerical method for solving two-sided space fractional partial differential equations in two-dimensional case.The approximation of the space fractional Riemann-Liouville derivative is based on the approximation of the Hadamard finite-part integral which has the convergence order O(h^3-a),where h is the space step size and α∈(1,2)is the order of Riemann-Liouville fractional derivative.Based on this scheme,we introduce a shifted finite difference method for solving space fractional partial differential equations.We obtained the error estimates with the convergence orders O(τ+h^3-a+h^β),where τ is the time step size and β>0 is a parameter which measures the smoothness of the fractional derivatives of the solution of the equation.Unlike the numerical methods for solving space fractional partial differential equations constructed using the standard shifted Griinwald-Letnikov formula or higher order Lubich's methods which require the solution of the equation to satisfy the homogeneous Dirichlet boundary condition to get the firstorder convergence,the numerical method for solving the space fractional partial differential equation constructed using the Hadamard finite-part integral approach does not require the solution of the equation to satisfy the Dirichlet homogeneous boundary condition.Numerical results show that the experimentally determined convergence order obtained using the Hadamard finite-part integral approach for solving the space fractional partial differential equation with non-homogeneous Dirichlet boundary conditions is indeed higher than the convergence order obtained using the numerical methods constructed with the standard shifted Griinwald-Letnikov formula or Lubich's higher order approximation schemes.
文摘A solid superacid catalyst Pt-SO42-/ZrO2-A12O3 for n-pentane isomerization, was prepared by incipient-wetness impregnation. Preparetion conditions, namely, calcination temperature, concentration of sulfuric acid solution used in impregnation and Al2O3 concentration, were varied to investigate the effects on catalytic performance of Pt-SO42-/ZrO2-A12O3. The results showed that the PtSZA catalyst exhibited excellent catalytic performance for n-pentane isomerization. Under optimized preparation conditions of calcination temperature of 650°C, reaction time for 3 h, concentration of sulfuric acid solution for 0.5 mol/L, 30% of Al2O3 concentration and 0.3% of Pt concentration, the n-pentane conversion and isopentane selectivity of Pt-SO42-/ZrO2-A12O3 could reach up to 62.17% and 91.60%, respectively.
