目的探讨嗅觉受体家族2亚家族W成员3(olfactory receptor family 2 subfamily W member,OR2W3)在胰腺癌(pancreatic cancer,PC)组织中的表达及其临床意义.方法采用免疫组织化学法检测50例PC组织及癌旁组织石蜡切片中的OR2W3的表达,分析O...目的探讨嗅觉受体家族2亚家族W成员3(olfactory receptor family 2 subfamily W member,OR2W3)在胰腺癌(pancreatic cancer,PC)组织中的表达及其临床意义.方法采用免疫组织化学法检测50例PC组织及癌旁组织石蜡切片中的OR2W3的表达,分析OR2W3蛋白表达与临床病理因素的关系.结果 OR2W3蛋白在PC组织中高表达和低表达率分别为78.0%(39/50)和22.0%(11/50),而在癌旁组织中高表达和低表达率分别为12.0%(6/50)和为88.0%(44/50),两者差异有统计学意义(χ2=44.00,P<0.05).单因素分析显示OR2W3表达与PC的组织分化程度、临床分期、淋巴结转移密切相关,该3因素分组间的差异均有统计学意义(均P<0.05).结论 OR2W3的高表达可能在PC发生、发展中起重要作用.展开更多
Acute pancreatitis(AP)is an inflammatory disease of the pancreas which involves the pancreas and surrounding tissue,and systemic inflammation with a characteristic systemic increase of vascular permeability and increa...Acute pancreatitis(AP)is an inflammatory disease of the pancreas which involves the pancreas and surrounding tissue,and systemic inflammation with a characteristic systemic increase of vascular permeability and increased risk of multiple organ dysfunction.Currently,the pathogenesis of AP is fuzzy,and the diagnosis and treatment need to be standardized.Nevertheless,increased knowledge of AP may achieve more thorough understanding of the pathogenesis.The use of further advanced diagnostic tools and superior treatment,potentially will help clinicians to manage AP at an appropriate stage.However,in view of the multi factorial disease and the complex clinical manifestations,the management of patients with AP is also remaining areas for improvement.展开更多
文摘目的探讨嗅觉受体家族2亚家族W成员3(olfactory receptor family 2 subfamily W member,OR2W3)在胰腺癌(pancreatic cancer,PC)组织中的表达及其临床意义.方法采用免疫组织化学法检测50例PC组织及癌旁组织石蜡切片中的OR2W3的表达,分析OR2W3蛋白表达与临床病理因素的关系.结果 OR2W3蛋白在PC组织中高表达和低表达率分别为78.0%(39/50)和22.0%(11/50),而在癌旁组织中高表达和低表达率分别为12.0%(6/50)和为88.0%(44/50),两者差异有统计学意义(χ2=44.00,P<0.05).单因素分析显示OR2W3表达与PC的组织分化程度、临床分期、淋巴结转移密切相关,该3因素分组间的差异均有统计学意义(均P<0.05).结论 OR2W3的高表达可能在PC发生、发展中起重要作用.
基金Supported by Grants from National Natural Science Foundation of China to Ren-Yi Qin,No.81071775 and No.81272659,Min Wang,No.81101621National"Eleventh Five-Year"Scientific and Technological Support Projects to Ren-Yi Qin,No.2006BAI02A13-402+1 种基金Key Projects of Science Foundation of Hubei Province to Ren-Yi Qin,No.2011CDA030Research Fund of Young Scholars for the Doctoral Program of Higher Education of China to Min Wang,No.20110142120014
文摘Acute pancreatitis(AP)is an inflammatory disease of the pancreas which involves the pancreas and surrounding tissue,and systemic inflammation with a characteristic systemic increase of vascular permeability and increased risk of multiple organ dysfunction.Currently,the pathogenesis of AP is fuzzy,and the diagnosis and treatment need to be standardized.Nevertheless,increased knowledge of AP may achieve more thorough understanding of the pathogenesis.The use of further advanced diagnostic tools and superior treatment,potentially will help clinicians to manage AP at an appropriate stage.However,in view of the multi factorial disease and the complex clinical manifestations,the management of patients with AP is also remaining areas for improvement.
