Objective:To analyze the hepatic protection of n-acetvl cysteine(NAC)on severe acute pancreatitis(SAP).Methods:SD rats were randomly divided into control group,SAP group and NAC group.SAP AHO method was adopted to est...Objective:To analyze the hepatic protection of n-acetvl cysteine(NAC)on severe acute pancreatitis(SAP).Methods:SD rats were randomly divided into control group,SAP group and NAC group.SAP AHO method was adopted to establish the model,2 h after modeling,rats in NAC group had intraperitoneal injection of NAC(200 mg/kg).Ten rals from each group were sacrifieed in even'6 and 12 h at different time[mints respectively.Liver damage,liver function and serum amylase,AST,ALT and malondialdehyde(MDA)were determined.Results:Serum amylase,AST,AIT and MDA content in SAP,NAC group at each time point were significantly higher in the control group(P<0.05),serum amylase,AST,ALT and MDA content in NAC group rats were lower in the SAP group significantly(P<0.05);Microscopic examination showed that the liver injury in rats and the NAC group significantly reduced in the SAP group.Conclusions:NAC provides effective protection against liver damage to SAP,protective from SAP liver injury.展开更多
Coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was found initially in Wuhan,China in early December 2019.The pandemic has spread to 216 countries and regio...Coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was found initially in Wuhan,China in early December 2019.The pandemic has spread to 216 countries and regions,infecting more than 23310000 people and causing over 800000 deaths globally by Aug.24,2020,according to World Health Organization(https://www.who.int/emergencies/diseases/novel-coronavirus-2019).Fever,cough,and dyspnea are the three common symptoms of the condition,whereas the conventional transmission route for SARS-CoV-2 is through droplets entering the respiratory tract.展开更多
基金supported by Scientific Research Fund Project Of Health Department,Sichuan Province(No:090498)
文摘Objective:To analyze the hepatic protection of n-acetvl cysteine(NAC)on severe acute pancreatitis(SAP).Methods:SD rats were randomly divided into control group,SAP group and NAC group.SAP AHO method was adopted to establish the model,2 h after modeling,rats in NAC group had intraperitoneal injection of NAC(200 mg/kg).Ten rals from each group were sacrifieed in even'6 and 12 h at different time[mints respectively.Liver damage,liver function and serum amylase,AST,ALT and malondialdehyde(MDA)were determined.Results:Serum amylase,AST,AIT and MDA content in SAP,NAC group at each time point were significantly higher in the control group(P<0.05),serum amylase,AST,ALT and MDA content in NAC group rats were lower in the SAP group significantly(P<0.05);Microscopic examination showed that the liver injury in rats and the NAC group significantly reduced in the SAP group.Conclusions:NAC provides effective protection against liver damage to SAP,protective from SAP liver injury.
基金Project supported by the Key Research and Development of Science and Technology Projects of Luzhou(Special Project Fund for Emergency Research),China。
文摘Coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was found initially in Wuhan,China in early December 2019.The pandemic has spread to 216 countries and regions,infecting more than 23310000 people and causing over 800000 deaths globally by Aug.24,2020,according to World Health Organization(https://www.who.int/emergencies/diseases/novel-coronavirus-2019).Fever,cough,and dyspnea are the three common symptoms of the condition,whereas the conventional transmission route for SARS-CoV-2 is through droplets entering the respiratory tract.
