A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the tw...A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.展开更多
基金This work is supported in part by a General Research Fund grant(601211)from the Research Grant CouncilThe Hong Kong Special Administrative Region,P.R.China+1 种基金The Hong Kong Chiu Chow Chamber of Commence HKUST Scholarship for Ph.D.Study(Y.L.)the Department of Chemistry,HKUST.
文摘A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.
