Robust Co_(3)O_(4)nanocatalysts supported on biomass-derived porous N-doped carbon toward low-pressure hydrogenation of furfural

The catalytic conversion of biomass platform chemicals using abundant non-noble metal nanocatalysts is a challenging topic.Here,high-density cobalt oxide nanoparticles loaded on biomass-derived porous N-doped carbon(NC)was fabricated by a tandem hydrothermal pyrolysis and mild nitrate decomposition process,which is a green and cheap preparation method.The Co_(3)O_(4) nanoparticles with the average size of 12 nm were uniformly distributed on the porous NC.The nanocomposites also possessed large surface area,high N content,good dispersibility in isopropanol,and furfural absorbability.Due to these characteristics,the novel cobalt nanocatalyst exhibited high catalytic activity for producing furfuryl alcohol,yielding 98.7%of the conversion and 97.1%of the selectivity at 160℃ for 6 h under 1 bar H2.The control experiments implied that both direct hydrogenation and transfer hydrogenation pathways co-existed in the hydrogenation reaction.The excellent catalytic activity of Co_(3)O_(4)@NC was attributed to the cooperative effects of porous NC and Co_(3)O_(4) nanoparticles.This approach provides a new idea to design effective high-density nonnoble metal oxide nanocatalysts for hydrogenation reactions,which can make full use of sustainable natural biomass.

Facile fabrication of superior antibacterial cotton fabric based on ZnO nanoparticles/quaternary ammonium salts hybrid composites and mechanism study

In the research for the safe and efficiently antibacterial cotton fabrics to minimize risk for human health,an organic–inorganic hybrid material of ZnO nanoparticles(NPs)and quaternary ammonium salt(QAS)was employed to modify cotton fabrics by a dipping–padding–drying method.The synergistic effects of ZnO NPs and QAS on the structure and antibacterial properties of cotton fabrics were studied in detail.Results displayed that the QAS and ZnO NPs were immobilized firmly in cotton fabric by the formation of chemical covalent bonds and silica gel structure.ZnO/QAS/cotton had a good inhibitory effect on the growth of E.coli and S.aureus,with superior antibacterial efficiency of>99.99%.ZnO/QAS/cotton preserved good mechanical property,water absorbability,and limpness.We also provided a detailed analysis of antibacterial mechanism for the hybrid materials.The contact mechanism and the Zn2+release were considered as the main mechanisms for the ZnO/QAS/cotton,while the reactive oxygen species(ROS)generation only had a little contribution to the antibacterial activity.In short,the excellent integrated properties endowed the hybrid cotton fabrics as potential application in many fields,like healthcare,food packaging.

Isolation and identification of phosphorylated lysine peptides by retention time difference combining dimethyl labeling strategy

Protein phosphorylation plays essential roles in various biological procedures. Despite the well-established enrichment strategies for O-phosphoproteomics, the intrinsic acid lability of N–P phosphoramidate bond(phosphorylation of histidine, arginine and lysine) has impaired the progress of N-phosphoproteomics. Herein, we reported a retention time difference combining dimethyl labeling(ReDD) strategy for the isolation and identification of phosphorylated lysine(pLys) peptides. By such a method, pLys peptide could be isolated under 100000-fold interference of non-phosphorylated peptides. Furthermore, ReDD strategy was applied to map pLys sites from E. coli samples, leading to the identification of 11 pLys sites, among which K26p that originating from autonomous glycyl radical cofactor was validated both in mass spectrometry and HPLC co-elution experiments. Furthermore, 112 pLys sites from 100 proteins were identified in HeLa cells. All these results demonstrate that ReDD could provide a first glimpse into Lys phosphorylation, and could be an important step toward the global perspective on protein phosphorylation.