基金supported by the National Program on Key Research Project of China(2019YFE0103900)as well as the European Union's Horizon 2020 Research and Innovation Program(861917-SAFFI)Zhejiang Provincial Key R&D Program of China(2023C03045)+3 种基金Ningbo Public Service Technology Foundation,China(2021S155)the Medical Scientific Research Foundationof Zhejang Province,China(2022KY1158 and 2024KY1557)Ningbo Natural Science Foundation,China(2023J203)Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City(2021JJLH0083).