Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(...Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers.展开更多
基金This work was supported in parts by the National Natural Science Foundation of China(82173688)the Chinese Ministry of Education 111 Project(BP0820034)+2 种基金The science and technology innovation Program of Hunan Province(2021 RC4067)Hunan Provincial Natural Science Foundation of China(2021J130791)the Hunan Provincial Innovation Foundation for Postgraduate(NO.2019zzts332).
文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers.
