Self-assembly is a process capitalized by nature for converting chemically simple building blocks into hierarchically ordered structures and materials to function in living systems cooperatively.1 Among all the buildi...Self-assembly is a process capitalized by nature for converting chemically simple building blocks into hierarchically ordered structures and materials to function in living systems cooperatively.1 Among all the building blocks,proteins are the most commonly utilized and form diverse structures ranging from oligomers and nanospheres to tubes and hierarchical architectures.2 These structures with unique physical properties play crucial roles in vast biological functions,for instance,structural support,cargo transport,and microbial defence.3 The formation of these structures is predominantly driven and governed by non-covalent interactions,conferring the dynamism and flexibility of these structures.By studying the fundamental principles that control the self-assembly processes of native proteins,functional materials can be replicated in a bottom-up approach.展开更多
Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubici...Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubicin(DNR)and cytarabine(ara-C)co-delivery system was developed by modifying the ara-C loaded liposomes(LIP-ara-C)with the hyaluronic acid-DNR(HA-DNR)prodrugs.The co-assembled hybrid nanoparticles(HA-DNR/LIP-ara-C HNPs)exhibited good serum and storage stability with an average diameter of approximately 100 nm.By specifically binding to the CD44 receptors that overexpressed on cancer cells,these HNPs could be uptake via endocytosis and accumulate intracellularly,in which an optimized DNR and ara-C combination at a molar ratio of 1:5 could generate enhanced synergistic effects with reduced dose-related toxicity on cancer cells.展开更多
文摘Self-assembly is a process capitalized by nature for converting chemically simple building blocks into hierarchically ordered structures and materials to function in living systems cooperatively.1 Among all the building blocks,proteins are the most commonly utilized and form diverse structures ranging from oligomers and nanospheres to tubes and hierarchical architectures.2 These structures with unique physical properties play crucial roles in vast biological functions,for instance,structural support,cargo transport,and microbial defence.3 The formation of these structures is predominantly driven and governed by non-covalent interactions,conferring the dynamism and flexibility of these structures.By studying the fundamental principles that control the self-assembly processes of native proteins,functional materials can be replicated in a bottom-up approach.
基金supported by the National Natural Science Foundation of China(Nos.81872823 and 82073782)the Double First-Class(No.CPU2018PZQ13)of the China Pharmaceutical University+1 种基金the Shanghai Science and Technology Committee(No.19430741500)the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(No.zdsys-202103)。
文摘Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubicin(DNR)and cytarabine(ara-C)co-delivery system was developed by modifying the ara-C loaded liposomes(LIP-ara-C)with the hyaluronic acid-DNR(HA-DNR)prodrugs.The co-assembled hybrid nanoparticles(HA-DNR/LIP-ara-C HNPs)exhibited good serum and storage stability with an average diameter of approximately 100 nm.By specifically binding to the CD44 receptors that overexpressed on cancer cells,these HNPs could be uptake via endocytosis and accumulate intracellularly,in which an optimized DNR and ara-C combination at a molar ratio of 1:5 could generate enhanced synergistic effects with reduced dose-related toxicity on cancer cells.
