Background The clinical value of programmed death-ligand 1(PD-L1)expression in colorectal liver oligometastases(CLOs)remains undefined.This study aimed to detect PD-L1 in the microenvironment of CLOs and determine its...Background The clinical value of programmed death-ligand 1(PD-L1)expression in colorectal liver oligometastases(CLOs)remains undefined.This study aimed to detect PD-L1 in the microenvironment of CLOs and determine its association with patient prognosis.Methods We collected 126 liver-resection specimens from CLO patients who underwent curative liver resection between June 1999 and December 2016.Immunohistochemistry(IHC)was performed to assess PD-L1 expression in paraffinembedded specimens.Overall survival(OS)and recurrence-free survival(RFS)were analysed using the Kaplan–Meier method and log-rank test.Results PD-L1 was mainly expressed in the stroma of liver oligometastases.Patients with high PD-L1 expression had a higher proportion of clinical-risk scores(CRSs)of 2–4(67.7%vs 40.4%;P=0.004).With a median 58-month follow-up,patients with high PD-L1 expression had a significantly lower 3-year OS rate(65.5%vs 92.7%;P=0.001)and 3-year RFS rate(34.7%vs 83.8%;P<0.001)than patients with low PD-L1 expression.Multivariate Cox analysis demonstrated that high PD-L1 expression(hazard ratio[HR]=3.581;95%confidence interval[CI]2.301–9.972;P=0.015),CRS 2–4(HR=6.960;95%CI 1.135–42.689;P=0.036)and increased preoperative CA19-9(HR=2.843;95%CI 1.229–6.576;P=0.015)were independent risk factors for OS.High PD-L1 expression(HR=4.815;95%CI 2.139–10.837;P<0.001)and lymph-node metastasis(HR=2.115;95%CI 1.041–4.297;P=0.038)were independent risk factors for RFS.Conclusion This study found that PD-L1 was commonly expressed in the tumour stroma of CLOs and high PD-L1 expression was associated with poor prognosis.展开更多
基金The present study was funded by grants from the National Natural Science Foundation of China[No.81772595]the Sun Yat-sen University Clinical Research 5010 Program[No.2015024 and 2013013]。
文摘Background The clinical value of programmed death-ligand 1(PD-L1)expression in colorectal liver oligometastases(CLOs)remains undefined.This study aimed to detect PD-L1 in the microenvironment of CLOs and determine its association with patient prognosis.Methods We collected 126 liver-resection specimens from CLO patients who underwent curative liver resection between June 1999 and December 2016.Immunohistochemistry(IHC)was performed to assess PD-L1 expression in paraffinembedded specimens.Overall survival(OS)and recurrence-free survival(RFS)were analysed using the Kaplan–Meier method and log-rank test.Results PD-L1 was mainly expressed in the stroma of liver oligometastases.Patients with high PD-L1 expression had a higher proportion of clinical-risk scores(CRSs)of 2–4(67.7%vs 40.4%;P=0.004).With a median 58-month follow-up,patients with high PD-L1 expression had a significantly lower 3-year OS rate(65.5%vs 92.7%;P=0.001)and 3-year RFS rate(34.7%vs 83.8%;P<0.001)than patients with low PD-L1 expression.Multivariate Cox analysis demonstrated that high PD-L1 expression(hazard ratio[HR]=3.581;95%confidence interval[CI]2.301–9.972;P=0.015),CRS 2–4(HR=6.960;95%CI 1.135–42.689;P=0.036)and increased preoperative CA19-9(HR=2.843;95%CI 1.229–6.576;P=0.015)were independent risk factors for OS.High PD-L1 expression(HR=4.815;95%CI 2.139–10.837;P<0.001)and lymph-node metastasis(HR=2.115;95%CI 1.041–4.297;P=0.038)were independent risk factors for RFS.Conclusion This study found that PD-L1 was commonly expressed in the tumour stroma of CLOs and high PD-L1 expression was associated with poor prognosis.
