The achievable precision of parameter estimation plays a significant role in evaluating a strategy of metrology.In practice,one may employ approximations in a theoretical model development for simplicity,which,however...The achievable precision of parameter estimation plays a significant role in evaluating a strategy of metrology.In practice,one may employ approximations in a theoretical model development for simplicity,which,however,will cause systematic error and lead to a loss of precision.We derive the error of maximum likelihood estimation in the weak-value amplification technique where the linear approximation of the coupling parameter is used.We show that this error is positively related to the coupling strength and can be effectively suppressed by improving the Fisher information.Considering the roles played by weak values and initial meter states in the weak-value amplification,we also point out that the estimation error can be decreased by several orders of magnitude by averaging the estimations resulted from different initial meter states or weak values.These results are finally illustrated in a numerical example where an extended linear response regime to the parameter is observed.展开更多
Electrochemical CO_(2) reduction reaction(CO_(2) RR)exhibits remarkable potential in producing valuable chemicals with renewable energy.Operating CO_(2) RR in acidic media is beneficial to solve the issue of low carbo...Electrochemical CO_(2) reduction reaction(CO_(2) RR)exhibits remarkable potential in producing valuable chemicals with renewable energy.Operating CO_(2) RR in acidic media is beneficial to solve the issue of low carbon utilization brought by(bi)carbonate formation at the cathode.Suppressing the competing hydrogen evolution reaction and achieving stable CO_(2) RR performance remains challenging.Herein,we constructed a 3-dimensional Cu(3D-Cu)gas diffusion electrode(GDE)to achieve efficient C_(2)H_(4) production with a partial current density(j C_(2)H_(4))of over 470 mA cm^(2) and a Faradaic efficiency(FE C_(2)H_(4)) of 40%.With pause electrolysis,the decay rate of the j C_(2)H_(4) is only half that of the traditional constant electrolysis.The GDE after constant electrolysis was found to suffer from severe salt formation,leading to the decreased activity and poor stability.展开更多
Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among...Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among patients undergoing retroperitoneal procedures,such as the laparoscopic partial nephrectomy(LPN).Methods This prospective,randomized,controlled study was conducted from August 2017 to November 2018 at Peking Union Medical College Hospital(Beijing,China).Patients who were scheduled for a LPN,aged 18・70 years old with an ASA physical status score of I-II were randomly assigned to receive either TQLB with 0.6 ml/kg of 0.5%ropivacaine plus general anesthesia(TQLB group)or general anesthesia alone(control group).Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion.The primary outcome was the cumulative consumption of morphine within 8 h after surgery.The secondary outcome included postoperative consump廿ons of morphine at other time points,pain score at rest and during activity,postoperative nausa and vomitting(PONV),and recovery related parameters.Results Totally 30 patients per group were recruited in the study.The 8 h consumption of morphine was lower in theTQLB group than in the control group(median,0.023 mg/kg vs.0.068 mg/kg,U=207.5,P<0.001).No significant differences were observed in postoperative pain scores between the two groups.Patients in the TQLB group had fewer episodes of PONV(20%vs.47%,χ2=4.&P=0.028)in the first 24 h after surgery and higher scores for quality of recovery(mean,13&6 vs.131.9,t=-2.164,P=0.035)120 h after surgery than the controls.Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN,as well as a lower incidence of PONV and improved quality of recovery.展开更多
Chronic diseases are a growing concern worldwide,with nearly 25% of adults suffering from one or more chronic health conditions,thus placing a heavy burden on individuals,families,and healthcare systems.With the adven...Chronic diseases are a growing concern worldwide,with nearly 25% of adults suffering from one or more chronic health conditions,thus placing a heavy burden on individuals,families,and healthcare systems.With the advent of the“Smart Healthcare”era,a series of cutting-edge technologies has brought new experiences to the management of chronic diseases.Among them,smart wearable technology not only helps people pursue a healthier lifestyle but also provides a continuous flow of healthcare data for disease diagnosis and treatment by actively recording physiological parameters and tracking the metabolic state.However,how to organize and analyze the data to achieve the ultimate goal of improving chronic disease management,in terms of quality of life,patient outcomes,and privacy protection,is an urgent issue that needs to be addressed.Artificial intelligence(AI)can provide intelligent suggestions by analyzing a patient’s physiological data from wearable devices for the diagnosis and treatment of diseases.In addition,blockchain can improve healthcare services by authorizing decentralized data sharing,protecting the privacy of users,providing data empowerment,and ensuring the reliability of data management.Integrating AI,blockchain,and wearable technology could optimize the existing chronic disease management models,with a shift from a hospital-centered model to a patient-centered one.In this paper,we conceptually demonstrate a patient-centric technical framework based on AI,blockchain,and wearable technology and further explore the application of these integrated technologies in chronic disease management.Finally,the shortcomings of this new paradigm and future research directions are also discussed.展开更多
AIM: To study the pathogenetic processes and the role of gene expression by microarray analyses in expediting our understanding of the molecular pathophysiology of pancreatic adenocarcinoma, and to identify the novel ...AIM: To study the pathogenetic processes and the role of gene expression by microarray analyses in expediting our understanding of the molecular pathophysiology of pancreatic adenocarcinoma, and to identify the novel cancer-associated genes.METHODS: Nine histologically defined pancreatic head adenocarcinoma specimens associated with clinical data were studied. Total RNA and mRNA were isolated and labeled by reverse transcription reaction with Cy5 and Cy3 for cDNA probe. The cDNA microarrays that represent a set of 4 096 human genes were hybridized with labeled cDNA probe and screened for molecular profiling analyses.RESULTS: Using this methodology, 184 genes were screened out for differences in gene expression level after nine couples of hybridizations. Of the 184 genes,87 were upregulated and 97 downregulated, including 11 novel human genes. In pancreatic adenocarcinoma tissue, several invasion and metastasis related genes showed their high expression levels, suggesting that poor prognosis of pancreatic adenocarcinoma might have a solid molecular biological basis.CONCLUSION: The application of cDNA microarray technique for analysis of gene expression patterns is a powerful strategy to identify novel cancer-associated genes, and to rapidly explore their role in clinical pancreatic adenocarcinoma. Microarray profiles provide us new insights into the carcinogenesis and invasive process of pancreatic adenocarcinoma. Our results suggest that a highly organized and structured process of tumor invasion exists in the pancreas.展开更多
The alloy Ni-Al26.6-Cr13.4-Co8.1-Ti4.3-W1.3-Mo0.9 (at. pct) was fabricated from superalloy K44 and Al element using vacuum induction and casting technique. Investigations to this alloy reveal that a new phase Cr3Ni2...The alloy Ni-Al26.6-Cr13.4-Co8.1-Ti4.3-W1.3-Mo0.9 (at. pct) was fabricated from superalloy K44 and Al element using vacuum induction and casting technique. Investigations to this alloy reveal that a new phase Cr3Ni2 possessing low melting point and poor ductility is formed, which is distributed as a network along NiAI matrix grain boundaries. Subsequent different solution and aging treatments are carried out and lead to microstructural changes to various extents. Rapid cooling after solution at 1250℃ for 20 h gives rise to macrocracks in the specimen while slow cooling after the same treatment results in the formation of spheric α-Cr solid solution and needle-like Ni3Al phase, which are embedded in NiAl matrix. It is comfirmed that aging treatments initiate lath-shaped Ni3Al phase and pearl-shaped α-Cr phase to precipitate from the NiAl matrix, which own orientation relationships with these precipitates.展开更多
How to effectively utilize the energy of the broad spectrum of sunlight is one of the basic problems in the research of tandem solar cells. Due to their size effect, quantum confinement effect and coupling effect, col...How to effectively utilize the energy of the broad spectrum of sunlight is one of the basic problems in the research of tandem solar cells. Due to their size effect, quantum confinement effect and coupling effect, colloidal quantum dots(QDs) exhibit new physical properties that bulk materials don’t possess.CdX(X = Se, S, etc.) and Pb X(X = Se, S, etc.) QDs prepared by hot-injection methods have been widely studied in the areas of photovolitaic devices. However, the surfactants surrounding QDs seriously hinder the charge transport of QDs based solar cells. Therefore, how to fabricate high-performance tandem solar cells via ligands engineering has become a major challenge. In this paper, the latest progress of colloidal QDs in the research of all-inorganic tandem solar cells was summarized. Firstly, the improvement of QDs surface ligands and the optimization of ligands engineering were discussed, and the control of the physical properties of QDs films were realized. From the aspects of colloidal QDs, ligand engineering, and solar cell preparation, the future development direction of colloidal QDs solar cells was proposed, providing technical guidances for the preparation of low-cost and high-efficiency nanocrystalline solar cells.展开更多
Objective:To explore a new artificial intelligence(AI)-aided method to assist the clinical diagnosis of tibial plateau fractures(TPFs)and further measure its validity and feasibility.Methods:A total of 542 X-rays of T...Objective:To explore a new artificial intelligence(AI)-aided method to assist the clinical diagnosis of tibial plateau fractures(TPFs)and further measure its validity and feasibility.Methods:A total of 542 X-rays of TPFs were collected as a reference database.An AI algorithm(RetinaNet)was trained to analyze and detect TPF on the X-rays.The ability of the AI algorithm was determined by indexes such as detection accuracy and time taken for analysis.The algorithm performance was also compared with orthopedic physicians.Results:The AI algorithm showed a detection accuracy of 0.91 for the identification of TPF,which was similar to the performance of orthopedic physicians(0.92±0.03).The average time spent for analysis of the AI was 0.56 s,which was 16 times faster than human performance(8.44±3.26 s).Conclusion:The AI algorithm is a valid and efficient method for the clinical diagnosis of TPF.It can be a useful assistant for orthopedic physicians,which largely promotes clinical workflow and further guarantees the health and security of patients.展开更多
As an extension of the"teleparallel"equivalent of general relativity,f(T)gravity is proposed to explain some puzzling cosmological behaviors,such as accelerating expansion of the Universe.Given the fact that modif...As an extension of the"teleparallel"equivalent of general relativity,f(T)gravity is proposed to explain some puzzling cosmological behaviors,such as accelerating expansion of the Universe.Given the fact that modified gravity also has impacts on the Solar System,we might test it during future interplanetary missions with ultrastable clocks.In this work,we investigate the effects of f(T)gravity on the dynamics of the clock and its time transfer link.Under these influences,theΛ-term and theα-term of f(T)gravity play important roles.Here,Λis the cosmological constant andαrepresents a model parameter in f(T)gravity that determines the divergence from teleparallel gravity at the first order approximation.We find that the signal of f(T)gravity in the time transfer is much more difficult to detect with the current state of development for clocks than those effects on dynamics of an interplanetary spacecraft with a bounded orbit with parameters 0.5 au≤a≤5.5 au and 0≤e≤0.1.展开更多
Many models of gamma-ray bursts suggest a common central engine; a black hole of several solar masses accreting matter from a disk at an accretion rate from 0.01 to 10 M⊙s^-1, the inner region of the disk is cooled b...Many models of gamma-ray bursts suggest a common central engine; a black hole of several solar masses accreting matter from a disk at an accretion rate from 0.01 to 10 M⊙s^-1, the inner region of the disk is cooled by neutrino emission and large amounts of its binding energy are liberated, which could trigger the fireball. We improve the neutrino- dominated accreting flows by including the effects of magnetic fields. We find that more than half of the liberated energy can be extracted directly by the large-scale magnetic fields in the disk, and it turns out that the temperature of the disk is a bit lower than the neutrino-dominated accreting flows without magnetic field. Therefore, the outflows are magnetically-dominated rather than neutrino dominated. In our model, the neutrino mechanism can fuel some GRBs (not the brightest ones), but cannot fuel X-ray flares. The magnetic processes (both BZ and electromagnetic luminosity from a disk) are viable mechanisms for most of GRBs and their following X-ray flares.展开更多
We model the evolution of the spin frequency's second derivative ν¨ and the braking index n of radio pulsars with simulations within the phenomenological model of their surface magnetic field evolution, which c...We model the evolution of the spin frequency's second derivative ν¨ and the braking index n of radio pulsars with simulations within the phenomenological model of their surface magnetic field evolution, which contains a long-term power-law decay modulated by short-term oscillations. For the pulsar PSR B0329+54, a model with three oscillation components can reproduce its ν¨ variation. We show that the "averaged" n is different from the instantaneous n, and its oscillation magnitude decreases abruptly as the time span increases, due to the "averaging" effect. The simulated timing residuals agree with the main features of the reported data. Our model predicts that the averaged ν¨ of PSR B0329+54 will start to decrease rapidly with newer data beyond those used in Hobbs et al. We further perform Monte Carlo simulations for the distribution of the reported data in |ν¨| and |n| versus characteristic age τcdiagrams.It is found that the magnetic field oscillation model with decay index α = 0 can reproduce the distributions quite well. Compared with magnetic field decay due to the ambipolar diffusion(α = 0.5) and the Hall cascade(α = 1.0), the model with no long term decay(α = 0) is clearly preferred for old pulsars by the p-values of the two-dimensional Kolmogorov-Smirnov test.展开更多
With tremendous advances in modem techniques, Einstein's general rela- tivity has become an inevitable part of deep space missions. We investigate the rela- tivistic algorithm for time transfer between the proper tim...With tremendous advances in modem techniques, Einstein's general rela- tivity has become an inevitable part of deep space missions. We investigate the rela- tivistic algorithm for time transfer between the proper time - of the onboard clock and the Geocentric Coordinate Time, which extends some previous works by including the effects of propagation of electromagnetic signals. In order to evaluate the implicit algebraic equations and integrals in the model, we take an analytic approach to work out their approximate values. This analytic model might be used in an onboard com- puter because of its limited capability to perform calculations. Taking an orbiter like Yinghuo-1 as an example, we find that the contributions of the Sun, the ground station and the spacecraft dominate the outcomes of the relativistic corrections to the model.展开更多
Considering the fact that the general theory of relativity has become an in- extricable part of deep space missions, we investigate the relativistic transformation between the proper time of an onboard clock τ and th...Considering the fact that the general theory of relativity has become an in- extricable part of deep space missions, we investigate the relativistic transformation between the proper time of an onboard clock τ and the Geocentric Coordinate Time (TCG) for Mars missions. By connecting τ with this local timescale associated with the Earth, we extend previous works which focus on the transformation between τ and the Barycentric Coordinate Time (TCB). (TCB is the global coordinate time for the whole solar system.) For practical convenience, the relation between τ and TCG is recast to directly depend on quantities which can be read from ephemerides. We find that the difference between τ and TCG can reach the level of about 0.2 seconds in a year. To distinguish various sources in the transformation, we numerically calculate the contributions caused by the Sun, eight planets, three large asteroids and the space- craft. It is found that if the threshold of 1 microsecond is adopted, this transformation must include effects due to the Sun, Venus, the Moon, Mars, Jupiter, Saturn and the velocities of the spacecraft and Earth.展开更多
In the context of the fact that Einstein's general relativity has become an inevitable part of deep space missions, we will extend previous works on relativistic transformation between the proper time ^- of a clock o...In the context of the fact that Einstein's general relativity has become an inevitable part of deep space missions, we will extend previous works on relativistic transformation between the proper time ^- of a clock onboard a spacecraft orbiting Mars and the Barycentric Coordinate Time (TCB) by taking the clock offset into ac- count and investigate its accessibility by Fourier analysis on the residuals after fitting the ^--TCB curve in terms of n-th order polynomials. We find that if the accuracy of a clock can achieve better than ~ 10-5 s or ~ 10-6 s (depending on the type of clock offset) in one year after calibration, the relativistic effects on the difference between 7- and TCB will need to be carefully considered.展开更多
The sensitivity of cancer cells to radiation therapy varies based on cell cycle phase. Here we evaluated the differences between X-ray and carbon-ion irradiation with respect to cellular radiosensitivity and cancer cy...The sensitivity of cancer cells to radiation therapy varies based on cell cycle phase. Here we evaluated the differences between X-ray and carbon-ion irradiation with respect to cellular radiosensitivity and cancer cycle arrest in the breast cancer cell line, MCF-7. The cell survival rate, cell cycle distribution and the presence of apoptosis were measured by clonogenic assay and flow cytometry. BRCA1 and p21 protein levels were analyzed by Western blot, and the levels of human telomerase reverse transcriptase(h TERT) m RNA expression and telomere length were detected with real-time polymerase chain reaction. The results show a significant dose-dependent effects on survival rate, apoptosis and protein levels in the carbon-ion group of MCF-7 cells. Decreased proliferation was not observed at 2 Gy X-ray irradiation. There were significant differences in cellular cycle arrest, apoptosis percentages and BRCA1 and p21 protein expression between X-ray and heavy-ion groups. The results indicatedthat increasing in BRCA1 and p21 expression, and attenuation of h TERT gene expression induced by heavy-ion irradiation in MCF-7 cells might relate to mechanism of cellular radiosensitivity in G2/M arrested phase.展开更多
Objective:The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins,ANTP-SMACN7,on lung cancer cells treated with accelerated carbon and F...Objective:The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins,ANTP-SMACN7,on lung cancer cells treated with accelerated carbon and Fe particle irradiation.Methods:The ANTP-SMACN7 fusion peptide was synthesized and linked to fluorescein isothiocyanate to determine its ability to penetrate cells.A549 and NCI-H460 cells,human non-small cell lung cancer(NSCLC)cell lines,were irradiated with X-ray or high linear energy transfer(LET)irradiation with or without ANTP-SMACN7 treatment.Cellular survival,apoptosis,and protein expression were studied by colony formation assays,flow cytometry,and western blot analyses,respectively.Results:ANTP-SMACN7 fusion proteins entered the cells and promoted A549 and NCI-H460 cell high LET irradiation radiosensitization.High LET irradiation was more efficient for clonogenic cell killing and the induction of apoptosis(P<0.05).Treatment with ANTP-SMACN7 significantly reduced the A549 and NCI-H460 cell clone-forming percentages and increased apoptosis through inhibition of the X-linked inhibitor of apoptosis protein and the activation of caspase-3 and caspase-9.Conclusions:Regarding pharmaceutical radiosensitization,these findings provided a way to improve high-LET clinical radiotherapy for NSCLC patients.展开更多
To assist conservationists and policymakers in managing and protecting forests in Beijing from the effects of climate change,this study predicts changes for 2012–2112 in habitable areas of three tree species—Betula ...To assist conservationists and policymakers in managing and protecting forests in Beijing from the effects of climate change,this study predicts changes for 2012–2112 in habitable areas of three tree species—Betula platyphylla,Quercus palustris,Platycladus orientalis,plus other mixed broadleaf species—in Beijing using a classification and regression tree niche model under the International Panel on Climate Change’s A2 and B2 emissions scenarios(SRES).The results show that climate change will increase annual average temperatures in the Beijing area by 2.0–4.7℃,and annual precipitation by 4.7–8.5 mm,depending on the emissions scenario used.These changes result in shifts in the range of each of the species.New suitable areas for distributions of B.platyphylla and Q.palustris will decrease in the future.The model points to significant shifts in the distributions of these species,withdrawing from their current ranges and pushing southward towards central Beijing.Most of the ranges decline during the initial 2012–2040 period before shifting southward and ending up larger overall at the end of the 88-year period.The mixed broadleaf forests expand their ranges significantly.The P.orientalis forests,on the other hand,expand their range marginally.The results indicate that climate change and its effects will accelerate significantly in Beijing over the next 88 years.Water stress is likely to be a major limiting factor on the distribution of forests and the most important factor affecting migration of species into and out of existing nature reserves.There is a potential for the extinction of some species.Therefore,long-term vegetation monitoring and warning systems will be needed to protect local species from habitat loss and genetic swamping of native species by hybrids.展开更多
BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two ca...BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two cases of which are unilateral scrotal agenesis and not accompanied by cryptorchidism.This is the first reported case of unilateral scrotal agenesis with cryptorchidism and scrotoplasty.CASE SUMMARY A 2-year-old boy was admitted to our hospital with left cryptorchidism and ipsilateral CSA.An innovative method was used in the patient where a scrotal skin pedicle from the right part of scrotal skin was transplanted to the left side.At the same time,descent orchiopexy was performed.At the 4-mo follow-up,the left testicle was located in the scrotum and the size and shape were normal.CONCLUSION For unilateral CSA with ipsilateral cryptorchidism,contralateral scrotal pedicle transplantation and descent orchiopexy appear to be a successful surgical option.展开更多
基金supported by the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0301601)the Science and Technology Innovation Program of Hunan Province (Grant No.2022RC1194)the National Natural Science Foundation of China (Grant Nos.11904402,12074433,12004430,12174447,12204543,and 12174448)。
文摘The achievable precision of parameter estimation plays a significant role in evaluating a strategy of metrology.In practice,one may employ approximations in a theoretical model development for simplicity,which,however,will cause systematic error and lead to a loss of precision.We derive the error of maximum likelihood estimation in the weak-value amplification technique where the linear approximation of the coupling parameter is used.We show that this error is positively related to the coupling strength and can be effectively suppressed by improving the Fisher information.Considering the roles played by weak values and initial meter states in the weak-value amplification,we also point out that the estimation error can be decreased by several orders of magnitude by averaging the estimations resulted from different initial meter states or weak values.These results are finally illustrated in a numerical example where an extended linear response regime to the parameter is observed.
基金the financial support from the Research Grants Council of the Hong Kong Special Administrative Region(project no.24304920).
文摘Electrochemical CO_(2) reduction reaction(CO_(2) RR)exhibits remarkable potential in producing valuable chemicals with renewable energy.Operating CO_(2) RR in acidic media is beneficial to solve the issue of low carbon utilization brought by(bi)carbonate formation at the cathode.Suppressing the competing hydrogen evolution reaction and achieving stable CO_(2) RR performance remains challenging.Herein,we constructed a 3-dimensional Cu(3D-Cu)gas diffusion electrode(GDE)to achieve efficient C_(2)H_(4) production with a partial current density(j C_(2)H_(4))of over 470 mA cm^(2) and a Faradaic efficiency(FE C_(2)H_(4)) of 40%.With pause electrolysis,the decay rate of the j C_(2)H_(4) is only half that of the traditional constant electrolysis.The GDE after constant electrolysis was found to suffer from severe salt formation,leading to the decreased activity and poor stability.
文摘Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among patients undergoing retroperitoneal procedures,such as the laparoscopic partial nephrectomy(LPN).Methods This prospective,randomized,controlled study was conducted from August 2017 to November 2018 at Peking Union Medical College Hospital(Beijing,China).Patients who were scheduled for a LPN,aged 18・70 years old with an ASA physical status score of I-II were randomly assigned to receive either TQLB with 0.6 ml/kg of 0.5%ropivacaine plus general anesthesia(TQLB group)or general anesthesia alone(control group).Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion.The primary outcome was the cumulative consumption of morphine within 8 h after surgery.The secondary outcome included postoperative consump廿ons of morphine at other time points,pain score at rest and during activity,postoperative nausa and vomitting(PONV),and recovery related parameters.Results Totally 30 patients per group were recruited in the study.The 8 h consumption of morphine was lower in theTQLB group than in the control group(median,0.023 mg/kg vs.0.068 mg/kg,U=207.5,P<0.001).No significant differences were observed in postoperative pain scores between the two groups.Patients in the TQLB group had fewer episodes of PONV(20%vs.47%,χ2=4.&P=0.028)in the first 24 h after surgery and higher scores for quality of recovery(mean,13&6 vs.131.9,t=-2.164,P=0.035)120 h after surgery than the controls.Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN,as well as a lower incidence of PONV and improved quality of recovery.
基金supported by the National Natural Science Foundation of China(No.81974355 and No.82172525)the National Intelligence Medical Clinical Research Center(No.2020021105012440)the Hubei Province Technology Innovation Major Special Project(No.2018AAA067).
文摘Chronic diseases are a growing concern worldwide,with nearly 25% of adults suffering from one or more chronic health conditions,thus placing a heavy burden on individuals,families,and healthcare systems.With the advent of the“Smart Healthcare”era,a series of cutting-edge technologies has brought new experiences to the management of chronic diseases.Among them,smart wearable technology not only helps people pursue a healthier lifestyle but also provides a continuous flow of healthcare data for disease diagnosis and treatment by actively recording physiological parameters and tracking the metabolic state.However,how to organize and analyze the data to achieve the ultimate goal of improving chronic disease management,in terms of quality of life,patient outcomes,and privacy protection,is an urgent issue that needs to be addressed.Artificial intelligence(AI)can provide intelligent suggestions by analyzing a patient’s physiological data from wearable devices for the diagnosis and treatment of diseases.In addition,blockchain can improve healthcare services by authorizing decentralized data sharing,protecting the privacy of users,providing data empowerment,and ensuring the reliability of data management.Integrating AI,blockchain,and wearable technology could optimize the existing chronic disease management models,with a shift from a hospital-centered model to a patient-centered one.In this paper,we conceptually demonstrate a patient-centric technical framework based on AI,blockchain,and wearable technology and further explore the application of these integrated technologies in chronic disease management.Finally,the shortcomings of this new paradigm and future research directions are also discussed.
基金Supported by the National Natural Science Foundation of China,No. 30000160
文摘AIM: To study the pathogenetic processes and the role of gene expression by microarray analyses in expediting our understanding of the molecular pathophysiology of pancreatic adenocarcinoma, and to identify the novel cancer-associated genes.METHODS: Nine histologically defined pancreatic head adenocarcinoma specimens associated with clinical data were studied. Total RNA and mRNA were isolated and labeled by reverse transcription reaction with Cy5 and Cy3 for cDNA probe. The cDNA microarrays that represent a set of 4 096 human genes were hybridized with labeled cDNA probe and screened for molecular profiling analyses.RESULTS: Using this methodology, 184 genes were screened out for differences in gene expression level after nine couples of hybridizations. Of the 184 genes,87 were upregulated and 97 downregulated, including 11 novel human genes. In pancreatic adenocarcinoma tissue, several invasion and metastasis related genes showed their high expression levels, suggesting that poor prognosis of pancreatic adenocarcinoma might have a solid molecular biological basis.CONCLUSION: The application of cDNA microarray technique for analysis of gene expression patterns is a powerful strategy to identify novel cancer-associated genes, and to rapidly explore their role in clinical pancreatic adenocarcinoma. Microarray profiles provide us new insights into the carcinogenesis and invasive process of pancreatic adenocarcinoma. Our results suggest that a highly organized and structured process of tumor invasion exists in the pancreas.
文摘The alloy Ni-Al26.6-Cr13.4-Co8.1-Ti4.3-W1.3-Mo0.9 (at. pct) was fabricated from superalloy K44 and Al element using vacuum induction and casting technique. Investigations to this alloy reveal that a new phase Cr3Ni2 possessing low melting point and poor ductility is formed, which is distributed as a network along NiAI matrix grain boundaries. Subsequent different solution and aging treatments are carried out and lead to microstructural changes to various extents. Rapid cooling after solution at 1250℃ for 20 h gives rise to macrocracks in the specimen while slow cooling after the same treatment results in the formation of spheric α-Cr solid solution and needle-like Ni3Al phase, which are embedded in NiAl matrix. It is comfirmed that aging treatments initiate lath-shaped Ni3Al phase and pearl-shaped α-Cr phase to precipitate from the NiAl matrix, which own orientation relationships with these precipitates.
基金the National Natural Science Foundation of China(No.51976081)。
文摘How to effectively utilize the energy of the broad spectrum of sunlight is one of the basic problems in the research of tandem solar cells. Due to their size effect, quantum confinement effect and coupling effect, colloidal quantum dots(QDs) exhibit new physical properties that bulk materials don’t possess.CdX(X = Se, S, etc.) and Pb X(X = Se, S, etc.) QDs prepared by hot-injection methods have been widely studied in the areas of photovolitaic devices. However, the surfactants surrounding QDs seriously hinder the charge transport of QDs based solar cells. Therefore, how to fabricate high-performance tandem solar cells via ligands engineering has become a major challenge. In this paper, the latest progress of colloidal QDs in the research of all-inorganic tandem solar cells was summarized. Firstly, the improvement of QDs surface ligands and the optimization of ligands engineering were discussed, and the control of the physical properties of QDs films were realized. From the aspects of colloidal QDs, ligand engineering, and solar cell preparation, the future development direction of colloidal QDs solar cells was proposed, providing technical guidances for the preparation of low-cost and high-efficiency nanocrystalline solar cells.
基金supported by the National Natural Science Foundation of China(No.81974355 and No.82172525).
文摘Objective:To explore a new artificial intelligence(AI)-aided method to assist the clinical diagnosis of tibial plateau fractures(TPFs)and further measure its validity and feasibility.Methods:A total of 542 X-rays of TPFs were collected as a reference database.An AI algorithm(RetinaNet)was trained to analyze and detect TPF on the X-rays.The ability of the AI algorithm was determined by indexes such as detection accuracy and time taken for analysis.The algorithm performance was also compared with orthopedic physicians.Results:The AI algorithm showed a detection accuracy of 0.91 for the identification of TPF,which was similar to the performance of orthopedic physicians(0.92±0.03).The average time spent for analysis of the AI was 0.56 s,which was 16 times faster than human performance(8.44±3.26 s).Conclusion:The AI algorithm is a valid and efficient method for the clinical diagnosis of TPF.It can be a useful assistant for orthopedic physicians,which largely promotes clinical workflow and further guarantees the health and security of patients.
基金Supported by the National Natural Science Foundation of China (Grant No. 11103010)funded by the Natural Science Foundation of China (Grant No. 11103085)+3 种基金the Fundamental Research Program of Jiangsu Province of China (Grant No. BK20131461Grant No. BK2011553)the Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20110091120003)the Fundamental Research Funds for the Central Universities (No. 1107020116)
文摘As an extension of the"teleparallel"equivalent of general relativity,f(T)gravity is proposed to explain some puzzling cosmological behaviors,such as accelerating expansion of the Universe.Given the fact that modified gravity also has impacts on the Solar System,we might test it during future interplanetary missions with ultrastable clocks.In this work,we investigate the effects of f(T)gravity on the dynamics of the clock and its time transfer link.Under these influences,theΛ-term and theα-term of f(T)gravity play important roles.Here,Λis the cosmological constant andαrepresents a model parameter in f(T)gravity that determines the divergence from teleparallel gravity at the first order approximation.We find that the signal of f(T)gravity in the time transfer is much more difficult to detect with the current state of development for clocks than those effects on dynamics of an interplanetary spacecraft with a bounded orbit with parameters 0.5 au≤a≤5.5 au and 0≤e≤0.1.
基金Supported by the National Natural Science Foundation of China.
文摘Many models of gamma-ray bursts suggest a common central engine; a black hole of several solar masses accreting matter from a disk at an accretion rate from 0.01 to 10 M⊙s^-1, the inner region of the disk is cooled by neutrino emission and large amounts of its binding energy are liberated, which could trigger the fireball. We improve the neutrino- dominated accreting flows by including the effects of magnetic fields. We find that more than half of the liberated energy can be extracted directly by the large-scale magnetic fields in the disk, and it turns out that the temperature of the disk is a bit lower than the neutrino-dominated accreting flows without magnetic field. Therefore, the outflows are magnetically-dominated rather than neutrino dominated. In our model, the neutrino mechanism can fuel some GRBs (not the brightest ones), but cannot fuel X-ray flares. The magnetic processes (both BZ and electromagnetic luminosity from a disk) are viable mechanisms for most of GRBs and their following X-ray flares.
基金Supported by the National Natural Science Foundation of China
文摘We model the evolution of the spin frequency's second derivative ν¨ and the braking index n of radio pulsars with simulations within the phenomenological model of their surface magnetic field evolution, which contains a long-term power-law decay modulated by short-term oscillations. For the pulsar PSR B0329+54, a model with three oscillation components can reproduce its ν¨ variation. We show that the "averaged" n is different from the instantaneous n, and its oscillation magnitude decreases abruptly as the time span increases, due to the "averaging" effect. The simulated timing residuals agree with the main features of the reported data. Our model predicts that the averaged ν¨ of PSR B0329+54 will start to decrease rapidly with newer data beyond those used in Hobbs et al. We further perform Monte Carlo simulations for the distribution of the reported data in |ν¨| and |n| versus characteristic age τcdiagrams.It is found that the magnetic field oscillation model with decay index α = 0 can reproduce the distributions quite well. Compared with magnetic field decay due to the ambipolar diffusion(α = 0.5) and the Hall cascade(α = 1.0), the model with no long term decay(α = 0) is clearly preferred for old pulsars by the p-values of the two-dimensional Kolmogorov-Smirnov test.
基金Supported by the National Natural Science Foundation of China
文摘With tremendous advances in modem techniques, Einstein's general rela- tivity has become an inevitable part of deep space missions. We investigate the rela- tivistic algorithm for time transfer between the proper time - of the onboard clock and the Geocentric Coordinate Time, which extends some previous works by including the effects of propagation of electromagnetic signals. In order to evaluate the implicit algebraic equations and integrals in the model, we take an analytic approach to work out their approximate values. This analytic model might be used in an onboard com- puter because of its limited capability to perform calculations. Taking an orbiter like Yinghuo-1 as an example, we find that the contributions of the Sun, the ground station and the spacecraft dominate the outcomes of the relativistic corrections to the model.
基金Supported by the National Natural Science Foundation of China
文摘Considering the fact that the general theory of relativity has become an in- extricable part of deep space missions, we investigate the relativistic transformation between the proper time of an onboard clock τ and the Geocentric Coordinate Time (TCG) for Mars missions. By connecting τ with this local timescale associated with the Earth, we extend previous works which focus on the transformation between τ and the Barycentric Coordinate Time (TCB). (TCB is the global coordinate time for the whole solar system.) For practical convenience, the relation between τ and TCG is recast to directly depend on quantities which can be read from ephemerides. We find that the difference between τ and TCG can reach the level of about 0.2 seconds in a year. To distinguish various sources in the transformation, we numerically calculate the contributions caused by the Sun, eight planets, three large asteroids and the space- craft. It is found that if the threshold of 1 microsecond is adopted, this transformation must include effects due to the Sun, Venus, the Moon, Mars, Jupiter, Saturn and the velocities of the spacecraft and Earth.
基金Supported by the National Natural Science Foundation of China
文摘In the context of the fact that Einstein's general relativity has become an inevitable part of deep space missions, we will extend previous works on relativistic transformation between the proper time ^- of a clock onboard a spacecraft orbiting Mars and the Barycentric Coordinate Time (TCB) by taking the clock offset into ac- count and investigate its accessibility by Fourier analysis on the residuals after fitting the ^--TCB curve in terms of n-th order polynomials. We find that if the accuracy of a clock can achieve better than ~ 10-5 s or ~ 10-6 s (depending on the type of clock offset) in one year after calibration, the relativistic effects on the difference between 7- and TCB will need to be carefully considered.
基金the National Natural Science Foundation of China(U1432248)Gansu Provincial Science and Technology Department(0702NKDA045)Japan Society for the Promotion of Science and National Institute of Radiological Sciences of Japan(11J364)
文摘The sensitivity of cancer cells to radiation therapy varies based on cell cycle phase. Here we evaluated the differences between X-ray and carbon-ion irradiation with respect to cellular radiosensitivity and cancer cycle arrest in the breast cancer cell line, MCF-7. The cell survival rate, cell cycle distribution and the presence of apoptosis were measured by clonogenic assay and flow cytometry. BRCA1 and p21 protein levels were analyzed by Western blot, and the levels of human telomerase reverse transcriptase(h TERT) m RNA expression and telomere length were detected with real-time polymerase chain reaction. The results show a significant dose-dependent effects on survival rate, apoptosis and protein levels in the carbon-ion group of MCF-7 cells. Decreased proliferation was not observed at 2 Gy X-ray irradiation. There were significant differences in cellular cycle arrest, apoptosis percentages and BRCA1 and p21 protein expression between X-ray and heavy-ion groups. The results indicatedthat increasing in BRCA1 and p21 expression, and attenuation of h TERT gene expression induced by heavy-ion irradiation in MCF-7 cells might relate to mechanism of cellular radiosensitivity in G2/M arrested phase.
基金supported by grants from the National Key R&D Program of China(Grant Nos.2018YFE0205100 and 2018YFE0205101)the National Natural Science Foundation of China(Grant Nos.11605260 and 31670859)+4 种基金the Key Research and Development Projects of Shanxi Province(Grant No.201903D321115)the Science and Technology Talent Project in Lanzhou(Grant No.2018-RC-66)the Science and Technology Project of Chengguan District of Lanzhou(Grant No.2020RCCX0038)the CAMS Innovation Fund for Medical Science(Grant No.2017-I2M-1-016)the Ministry of Education,Culture,Sports,and Science Technology Grantin-Aid for Scientific Research on Innovative Areas with Heavy Ions at NIRS-HIMAC,Japan[Grant Nos.JP15K21745,15H05944,and 15H05935(Living in Space),and Research Project Grant(14J313)].
文摘Objective:The aim of the present study was to investigate the mechanisms responsible for the radiation-sensitizing effect of antennapedia proteins,ANTP-SMACN7,on lung cancer cells treated with accelerated carbon and Fe particle irradiation.Methods:The ANTP-SMACN7 fusion peptide was synthesized and linked to fluorescein isothiocyanate to determine its ability to penetrate cells.A549 and NCI-H460 cells,human non-small cell lung cancer(NSCLC)cell lines,were irradiated with X-ray or high linear energy transfer(LET)irradiation with or without ANTP-SMACN7 treatment.Cellular survival,apoptosis,and protein expression were studied by colony formation assays,flow cytometry,and western blot analyses,respectively.Results:ANTP-SMACN7 fusion proteins entered the cells and promoted A549 and NCI-H460 cell high LET irradiation radiosensitization.High LET irradiation was more efficient for clonogenic cell killing and the induction of apoptosis(P<0.05).Treatment with ANTP-SMACN7 significantly reduced the A549 and NCI-H460 cell clone-forming percentages and increased apoptosis through inhibition of the X-linked inhibitor of apoptosis protein and the activation of caspase-3 and caspase-9.Conclusions:Regarding pharmaceutical radiosensitization,these findings provided a way to improve high-LET clinical radiotherapy for NSCLC patients.
基金This research was supported by the Fundamental Research Funds for the Central University(2018RD001).
文摘To assist conservationists and policymakers in managing and protecting forests in Beijing from the effects of climate change,this study predicts changes for 2012–2112 in habitable areas of three tree species—Betula platyphylla,Quercus palustris,Platycladus orientalis,plus other mixed broadleaf species—in Beijing using a classification and regression tree niche model under the International Panel on Climate Change’s A2 and B2 emissions scenarios(SRES).The results show that climate change will increase annual average temperatures in the Beijing area by 2.0–4.7℃,and annual precipitation by 4.7–8.5 mm,depending on the emissions scenario used.These changes result in shifts in the range of each of the species.New suitable areas for distributions of B.platyphylla and Q.palustris will decrease in the future.The model points to significant shifts in the distributions of these species,withdrawing from their current ranges and pushing southward towards central Beijing.Most of the ranges decline during the initial 2012–2040 period before shifting southward and ending up larger overall at the end of the 88-year period.The mixed broadleaf forests expand their ranges significantly.The P.orientalis forests,on the other hand,expand their range marginally.The results indicate that climate change and its effects will accelerate significantly in Beijing over the next 88 years.Water stress is likely to be a major limiting factor on the distribution of forests and the most important factor affecting migration of species into and out of existing nature reserves.There is a potential for the extinction of some species.Therefore,long-term vegetation monitoring and warning systems will be needed to protect local species from habitat loss and genetic swamping of native species by hybrids.
基金Supported by the National Natural Science Foundation of China,No.81602219
文摘BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two cases of which are unilateral scrotal agenesis and not accompanied by cryptorchidism.This is the first reported case of unilateral scrotal agenesis with cryptorchidism and scrotoplasty.CASE SUMMARY A 2-year-old boy was admitted to our hospital with left cryptorchidism and ipsilateral CSA.An innovative method was used in the patient where a scrotal skin pedicle from the right part of scrotal skin was transplanted to the left side.At the same time,descent orchiopexy was performed.At the 4-mo follow-up,the left testicle was located in the scrotum and the size and shape were normal.CONCLUSION For unilateral CSA with ipsilateral cryptorchidism,contralateral scrotal pedicle transplantation and descent orchiopexy appear to be a successful surgical option.