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Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation 被引量:6
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作者 Lei Zhou Lei Fan +11 位作者 Feng-Miao Zhang Yuhe Jiang Min Cai Cong Dai yi-an luo Ling-Jie Tu Zheng-Nan Zhou Xiao-Jun Li Cheng-Yun Ning Kai Zheng Aldo R.Boccaccini Guo-Xin Tan 《Bioactive Materials》 SCIE 2021年第3期890-904,共15页
Biopolymer based hydrogels are characteristic of their biocompatibility and capability of mimicking extracellular matrix structure to support cellular behavior.However,these hydrogels suffer from low mechanical proper... Biopolymer based hydrogels are characteristic of their biocompatibility and capability of mimicking extracellular matrix structure to support cellular behavior.However,these hydrogels suffer from low mechanical properties,uncontrolled degradation,and insufficient osteogenic activity,which limits their applications in bone regeneration.In this study,we developed hybrid gelatin(Gel)/oxidized chondroitin sulfate(OCS)hydrogels that incorporated mesoporous bioactive glass nanoparticles(MBGNs)as bioactive fillers for bone regeneration.Gel-OCS hydrogels could be self-crosslinked in situ under physiological conditions in the presence of borax.The incorporation of MBGNs enhanced the crosslinking and accelerated the gelation.The gelation time decreased with increasing the concentration of MBGNs added.Incorporation of MBGNs in the hydrogels significantly improved the mechanical properties in terms of enhanced storage modulus and compressive strength.The injectability of the hydrogels was not significantly affected by the MBGN incorporation.Also,the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and rat cranial defect restoration in vivo were significantly promoted by the hydrogels in the presence of MBGNs.The hybrid Gel-OCS/MBGN hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration/repair applications given their tunable degradation and gelation behavior as well as favorable mechanical behavior and osteogenic activities. 展开更多
关键词 HYDROGELS Bioactive glasses Biopolymers HYBRIDS Bone regeneration
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