期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Regulating effect of borosilicate bioglass extract on the osteoblast proliferation activity and osteogenesis signaling pathway function
1
作者 Xiao-Hui He Wu-Sheng Chen +3 位作者 yi-fan zhuang Dao-Qing Wang Xi-Yi Wang Xin-Hong zhuang 《Journal of Hainan Medical University》 2017年第21期13-16,共4页
Objective: To study the regulating effect of borosilicate bioglass extract on the osteoblast proliferation activity and osteogenesis signaling pathway function. Methods: Osteoblasts MG-63 were cultured and divided int... Objective: To study the regulating effect of borosilicate bioglass extract on the osteoblast proliferation activity and osteogenesis signaling pathway function. Methods: Osteoblasts MG-63 were cultured and divided into borosilicate group and control group that were treated with the culture medium containing borosilicate bioglass extract and the culture medium without extract respectively. After 24 h of treatment, the cell proliferation activity as well as the expression of proliferation activity markers, Wnt signaling pathway molecules and PI3K/AKT signaling pathway molecules was measured. Results: After 24 h of treatment, MTT cell viability of borosilicate group was significantly higher than that of control group, and ALP, OC, OPN, COL-I, Runx2, Wnt1, Wnt3a, β-catenin, LRP5, LRP6, p-PI3K, p-AKT, Bcl-2 and BMP protein expression in cells were significantly higher than those of control group. Conclusion: Borosilicate bioglass extract can enhance the proliferation activity of osteoblasts by activating Wnt pathway and PI3K/AKT pathway. 展开更多
关键词 OSTEOBLAST BOROSILICATE BIOGLASS Proliferation ACTIVITY Signaling pathway
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部