Gestational diabetes mellitus(GDM)is the most common glucose metabolism complication or cause of potential impaired glucose tolerance that can occur either before or during pregnancy and lactation.The prevalence of GD...Gestational diabetes mellitus(GDM)is the most common glucose metabolism complication or cause of potential impaired glucose tolerance that can occur either before or during pregnancy and lactation.The prevalence of GDM and its related complications in young women is increasing,and this condition may cause serious outcomes and health hazards to the foetus.However,traditional oral hypoglycaemic drugs have potential safety hazards;therefore,it is urgent to develop new,safe,effective,and easily administered agents and remedies.Ginseng polysaccharide(GPS),which is isolated from Panax(P.)ginseng C.A.Meyer,exhibits notably promising biological activities and effects;specifically,it has been shown to lower blood glucose with mild,safe,and nontoxic characteristics,and it can also improve human bodily functions.Hence,we hypothesise that GPS might be used as an additional therapy and candidate agent for treating GDM.This review innovatively summarizes the available reports and evidence from basic studies to analyze the potential for and feasibility of using GPS as a new therapeutic agent for treating GDM.Additionally,for the first time,this review provides a rationale for the use of GPS.Our summarized results show that GPS may be developed as a novel antidiabetic drug and a remedy for use in preventing and treating GDM,with great application prospects.展开更多
Objective To develop an efficient method for separating and purifying puerarin from the roots of Pueraria lobata.Methods Separation by fast centrifugal partition chromatography（FCPC）was processed with a biphasic sol...Objective To develop an efficient method for separating and purifying puerarin from the roots of Pueraria lobata.Methods Separation by fast centrifugal partition chromatography（FCPC）was processed with a biphasic solvent system composed of ethyl acetate-n-butanol-water（2：1：3）.The separation conditions were determined as follows：sample loading of 10 mg,flow rate of 2 mL/min,rotation speed of 2200 r/min,ascending mode,and detection wavelength of 254 nm.High speed countercurrent chromatography（HSCCC）was used as a comparative method with the rotation speed of 800 r/min,flow rate of 2.0 mL/min,and sample loading of 10 mg in tail-to-head mode.Results Puerarin was obtained by FCPC with a resolution of 0.90 and a purity above 99%,while a resolution below 0.50 and a purity below 90%by HSCCC.Compared with HSCCC,FCPC has the advantages with higher purity and better resolution.Conclusion FCPC is a powerful method to separate and purify puerarin.展开更多
基金Science and Technology Department of Guizhou Province,No.[2019]9-2-25。
文摘Gestational diabetes mellitus(GDM)is the most common glucose metabolism complication or cause of potential impaired glucose tolerance that can occur either before or during pregnancy and lactation.The prevalence of GDM and its related complications in young women is increasing,and this condition may cause serious outcomes and health hazards to the foetus.However,traditional oral hypoglycaemic drugs have potential safety hazards;therefore,it is urgent to develop new,safe,effective,and easily administered agents and remedies.Ginseng polysaccharide(GPS),which is isolated from Panax(P.)ginseng C.A.Meyer,exhibits notably promising biological activities and effects;specifically,it has been shown to lower blood glucose with mild,safe,and nontoxic characteristics,and it can also improve human bodily functions.Hence,we hypothesise that GPS might be used as an additional therapy and candidate agent for treating GDM.This review innovatively summarizes the available reports and evidence from basic studies to analyze the potential for and feasibility of using GPS as a new therapeutic agent for treating GDM.Additionally,for the first time,this review provides a rationale for the use of GPS.Our summarized results show that GPS may be developed as a novel antidiabetic drug and a remedy for use in preventing and treating GDM,with great application prospects.
基金International Science and Technology cooperation project of Shanghai(No.12120701400,2012)
文摘Objective To develop an efficient method for separating and purifying puerarin from the roots of Pueraria lobata.Methods Separation by fast centrifugal partition chromatography（FCPC）was processed with a biphasic solvent system composed of ethyl acetate-n-butanol-water（2：1：3）.The separation conditions were determined as follows：sample loading of 10 mg,flow rate of 2 mL/min,rotation speed of 2200 r/min,ascending mode,and detection wavelength of 254 nm.High speed countercurrent chromatography（HSCCC）was used as a comparative method with the rotation speed of 800 r/min,flow rate of 2.0 mL/min,and sample loading of 10 mg in tail-to-head mode.Results Puerarin was obtained by FCPC with a resolution of 0.90 and a purity above 99%,while a resolution below 0.50 and a purity below 90%by HSCCC.Compared with HSCCC,FCPC has the advantages with higher purity and better resolution.Conclusion FCPC is a powerful method to separate and purify puerarin.
